butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Hidaka M et al. | Three lysophosphatidic acids with a distinct long chain moiety differently affect cell differentiation of human colon epithelial cells to goblet cells. | 2018 | Life Sci. | pmid:29412173 |
da Silva JS et al. | Nutritive value and fermentation quality of palisadegrass and stylo mixed silages. | 2018 | Anim. Sci. J. | pmid:28905506 |
Johnson J et al. | Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. | 2018 | Neurotoxicology | pmid:28610743 |
Sun H et al. | Effects of addition of Aspergillus oryzae culture and 2-hydroxyl-4-(methylthio) butanoic acid on milk performance and rumen fermentation of dairy cows. | 2017 | Anim. Sci. J. | pmid:27506446 |
Wang Y et al. | A Co-Drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation. | 2017 | J. Invest. Dermatol. | pmid:27498050 |
Zhu J et al. | Sodium butyrate modulates a methamphetamine-induced conditioned place preference. | 2017 | J. Neurosci. Res. | pmid:27426635 |
Liangzhan S et al. | Effect of substitution of oat hulls for traditional fiber source on digestion and performance of fattening rabbits. | 2017 | Animal | pmid:27821223 |
Tayebi B et al. | Modulation of microRNAs expression in hematopoietic stem cells treated with sodium butyrate in inducing fetal hemoglobin expression. | 2017 | Artif Cells Nanomed Biotechnol | pmid:26837891 |
Zhang Q et al. | Histone acetylation and reactive oxygen species are involved in the preprophase arrest induced by sodium butyrate in maize roots. | 2017 | Protoplasma | pmid:26781092 |
Kamphayae S et al. | Effects of graded levels of liquid brewer's yeast on chemical composition and fermentation quality in cassava pulp and rice straw-based total mixed ration silage. | 2017 | Anim. Sci. J. | pmid:27611881 |
Gulfam A et al. | Characteristics of lactic acid bacteria isolates and their effect on the fermentation quality of Napier grass silage at three high temperatures. | 2017 | J. Sci. Food Agric. | pmid:27539868 |
Sasajima H et al. | Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra. | 2017 | Biol. Pharm. Bull. | pmid:28049942 |
Kurano M et al. | Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. | 2017 | PLoS ONE | pmid:28494002 |
Machado CF et al. | Conditional Deletion of in Olfactory Sensory Neurons Leads to Olfactory Impairment. | 2017 | J. Neurosci. | pmid:29118104 |
Kobayashi H et al. | Clostridium pabulibutyricum sp. nov., a butyric-acid-producing organism isolated from high-moisture grass silage. | 2017 | Int. J. Syst. Evol. Microbiol. | pmid:29034861 |
Du H et al. | Exploring the microbial origins of p-cresol and its co-occurrence pattern in the Chinese liquor-making process. | 2017 | Int. J. Food Microbiol. | pmid:28843121 |
Wu T et al. | Anthocyanins in black rice, soybean and purple corn increase fecal butyric acid and prevent liver inflammation in high fat diet-induced obese mice. | 2017 | Food Funct | pmid:28792056 |
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Tsung AJ et al. | Methylation regulates HEY1 expression in glioblastoma. | 2017 | Oncotarget | pmid:28574840 |
Wang L et al. | Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. | 2017 | J. Hypertens. | pmid:28509726 |
Dou X et al. | Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon Toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells. | 2017 | Oncotarget | pmid:28460447 |
Pant K et al. | Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. | 2017 | Redox Biol | pmid:28288414 |
Niwińska B et al. | Review: Exogenous butyrate: implications for the functional development of ruminal epithelium and calf performance. | 2017 | Animal | pmid:28193308 |
Jaworska J et al. | The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. | 2017 | J Neuroinflammation | pmid:28187734 |
Qiu Y et al. | Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. | 2017 | In Vitro Cell. Dev. Biol. Anim. | pmid:28127702 |
Tylichová Z et al. | Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation. | 2017 | J. Nutr. Biochem. | pmid:27840291 |
Owusu BY and Klampfer L | Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases. | 2017 | Methods Mol. Biol. | pmid:27761828 |
Andersen AD et al. | Supplementation with Lactobacillus paracasei or Pediococcus pentosaceus does not prevent diarrhoea in neonatal pigs infected with Escherichia coli F18. | 2017 | Br. J. Nutr. | pmid:28720151 |
Hrgovic I et al. | Histone deacetylase inhibitors interfere with angiogenesis by decreasing endothelial VEGFR-2 protein half-life in part via a VE-cadherin-dependent mechanism. | 2017 | Exp. Dermatol. | pmid:27487811 |
Yokoyama Y et al. | Profile of preoperative fecal organic acids closely predicts the incidence of postoperative infectious complications after major hepatectomy with extrahepatic bile duct resection: Importance of fecal acetic acid plus butyric acid minus lactic acid gap. | 2017 | Surgery | pmid:28684159 |
Green AL et al. | Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. | 2017 | Neuropharmacology | pmid:28743636 |
Pant K et al. | Oxidative stress plays a key role in butyrate-mediated autophagy via Akt/mTOR pathway in hepatoma cells. | 2017 | Chem. Biol. Interact. | pmid:28600122 |
Yang S et al. | Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. | 2017 | Chem. Res. Toxicol. | pmid:28595002 |
Zapletal O et al. | Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models. | 2017 | Arch. Toxicol. | pmid:27830268 |
Hofmanová J et al. | Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities. | 2017 | Eur J Nutr | pmid:26983609 |
Li P et al. | Effect of grape pomace on fermentation quality and aerobic stability of sweet sorghum silage. | 2017 | Anim. Sci. J. | pmid:28485116 |
Seifrtová M et al. | Haemanthamine alters sodium butyrate-induced histone acetylation, p21 expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells. | 2017 | Phytomedicine | pmid:28991639 |
Sałkowska A et al. | Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of RORγT in human lymphocytes. | 2017 | J. Leukoc. Biol. | pmid:28951421 |
Wu Q et al. | Tailoring the Oxidative Stress Tolerance of Clostridium tyrobutyricum CCTCC W428 by Introducing Trehalose Biosynthetic Capability. | 2017 | J. Agric. Food Chem. | pmid:28925260 |
Sanz M et al. | Namalides B and C and Spumigins K-N from the Cultured Freshwater Cyanobacterium Sphaerospermopsis torques-reginae. | 2017 | J. Nat. Prod. | pmid:28876933 |
Górka P et al. | Effect of butyrate infusion into the rumen on butyrate flow to the duodenum, selected gene expression in the duodenum epithelium, and nutrient digestion in sheep. | 2017 | J. Anim. Sci. | pmid:28726987 |
Chang PJ et al. | Effects of the NEDD8-Activating Enzyme Inhibitor MLN4924 on Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. | 2017 | J. Virol. | pmid:28701396 |
Ito T et al. | Occurrence of the (2R,3S)-Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus. | 2017 | J. Agric. Food Chem. | pmid:28686838 |
Chen X et al. | Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. | 2017 | Biochem. Pharmacol. | pmid:28684304 |
Yan H and Ajuwon KM | Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. | 2017 | PLoS ONE | pmid:28654658 |
Batlle-Vilanova P et al. | Microbial electrosynthesis of butyrate from carbon dioxide: Production and extraction. | 2017 | Bioelectrochemistry | pmid:28633067 |
Asquith M et al. | Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis. | 2017 | pmid:28622455 | |
Lucchetti D et al. | Differentiation Affects the Release of Exosomes from Colon Cancer Cells and Their Ability to Modulate the Behavior of Recipient Cells. | 2017 | Am. J. Pathol. | pmid:28619275 |
Meenongyai W et al. | Effects of forage ensiling and ration fermentation on total mixed ration pH, ruminal fermentation and performance of growing Holstein-Zebu cross steers. | 2017 | Anim. Sci. J. | pmid:28370998 |
Lu N et al. | Butyric acid regulates progesterone and estradiol secretion via cAMP signaling pathway in porcine granulosa cells. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28602959 |
Zheng ML et al. | Dynamics of microbial community during ensiling direct-cut alfalfa with and without LAB inoculant and sugar. | 2017 | J. Appl. Microbiol. | pmid:28370869 |
Kumar P et al. | Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis in haplotype male mice. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28566502 |
Tian L et al. | Sodium butyrate improved intestinal immune function associated with NF-κB and p38MAPK signalling pathways in young grass carp (Ctenopharyngodon idella). | 2017 | Fish Shellfish Immunol. | pmid:28546021 |
Wu Q et al. | Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28536840 |
Kihara T et al. | Bacillus cereus-type polyhydroxyalkanoate biosynthetic gene cluster contains R-specific enoyl-CoA hydratase gene. | 2017 | Biosci. Biotechnol. Biochem. | pmid:28532241 |
Payandeh S et al. | Probiotic supplementation effects on milk fatty acid profile in ewes. | 2017 | J. Dairy Res. | pmid:28524013 |
Donovan JD et al. | In Vitro Digestion and Fermentation of Microencapsulated Tributyrin for the Delivery of Butyrate. | 2017 | J. Food Sci. | pmid:28485486 |
Zhou Z et al. | Changes of cecal microflora in chickens following Eimeria tenella challenge and regulating effect of coated sodium butyrate. | 2017 | Exp. Parasitol. | pmid:28455119 |
Suo Y et al. | Enhanced butyric acid tolerance and production by Class I heat shock protein-overproducing Clostridium tyrobutyricum ATCC 25755. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:28439766 |
Arriaga JM et al. | Metallothionein 1G promotes the differentiation of HT-29 human colorectal cancer cells. | 2017 | Oncol. Rep. | pmid:28393194 |
Foote AP et al. | Effect of abomasal butyrate infusion on gene expression in the duodenum of lambs. | 2017 | J. Anim. Sci. | pmid:28380531 |
Lynch H et al. | Investigation of in-feed organic acids as a low cost strategy to combat Salmonella in grower pigs. | 2017 | Prev. Vet. Med. | pmid:28364832 |
Fu H et al. | Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose co-utilization. | 2017 | Bioresour. Technol. | pmid:28343058 |
Kim YH and Lee JK | Histone deacetylase inhibitors suppress immature dendritic cell's migration by regulating CC chemokine receptor 1 expression. | 2017 | Cell. Immunol. | pmid:28341057 |
Egawa G et al. | SCFAs Control Skin Immune Responses via Increasing Tregs. | 2017 | J. Invest. Dermatol. | pmid:28340682 |
Olsen S | Effects of ultra-high dilutions of sodium butyrate on viability and gene expression in HEK 293 cells. | 2017 | Homeopathy | pmid:28325222 |
Zhang J et al. | Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from sugarcane juice. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28238080 |
Mathew MP et al. | Glycoengineering of Esterase Activity through Metabolic Flux-Based Modulation of Sialic Acid. | 2017 | Chembiochem | pmid:28218815 |
Maeshige N et al. | Low-Intensity Ultrasound Enhances Histone Acetylation and Inhibition of Interleukin 6 Messenger RNA Expression by the Histone Deacetylase Inhibitor Sodium Butyrate in Fibroblasts. | 2017 | J Ultrasound Med | pmid:28195362 |
Yoo M et al. | Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum. | 2017 | Metab. Eng. | pmid:28159643 |
Chen C et al. | Use of Acetate, Propionate, and Butyrate for Reduction of Nitrate and Sulfate and Methanogenesis in Microcosms and Bioreactors Simulating an Oil Reservoir. | 2017 | Appl. Environ. Microbiol. | pmid:28130297 |
Nakazawa A et al. | Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids. | 2017 | J. UOEH | pmid:28331124 |
Zhang L et al. | Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice. | 2017 | J. Cell. Biochem. | pmid:28109123 |
Cueno ME et al. | Periodontal disease level-butyric acid putatively contributes to the ageing blood: A proposed link between periodontal diseases and the ageing process. | 2017 | Mech. Ageing Dev. | pmid:28108180 |
Zhou D et al. | Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier. | 2017 | World J. Gastroenterol. | pmid:28104981 |
Huang JC et al. | [Protective effect of histone acetylation against cortical injury in neonatal rats]. | 2017 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:28100329 |
Albuquerque Filho MO et al. | Dual influences of early-life maternal deprivation on histone deacetylase activity and recognition memory in rats. | 2017 | Neuroscience | pmid:28089578 |
Kataoka N et al. | Butyrate production under aerobic growth conditions by engineered Escherichia coli. | 2017 | J. Biosci. Bioeng. | pmid:28089378 |
Hichino A et al. | Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells. | 2017 | J. Biol. Chem. | pmid:28057758 |
Millat T and Winzer K | Mathematical modelling of clostridial acetone-butanol-ethanol fermentation. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28210797 |
Fu H et al. | Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose. | 2017 | Metab. Eng. | pmid:28040464 |
Jin X et al. | TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment. | 2017 | Cancer Med | pmid:28033672 |
Dai H et al. | Sodium Butyrate Ameliorates High-Concentrate Diet-Induced Inflammation in the Rumen Epithelium of Dairy Goats. | 2017 | J. Agric. Food Chem. | pmid:28032994 |
Bosmans JW et al. | Comparison of three different application routes of butyrate to improve colonic anastomotic strength in rats. | 2017 | Int J Colorectal Dis | pmid:27942836 |
Johnstone M et al. | Characterization of the Pro-Inflammatory Cytokine IL-1β on Butyrate Oxidation in Colorectal Cancer Cells. | 2017 | J. Cell. Biochem. | pmid:27922186 |
Shirasugi M et al. | Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27914813 |
Yan JK et al. | Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27888107 |
Schwarz A et al. | The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. | 2017 | J. Invest. Dermatol. | pmid:27887954 |
Ra CH et al. | Hyper-thermal acid hydrolysis and adsorption treatment of red seaweed, Gelidium amansii for butyric acid production with pH control. | 2017 | Bioprocess Biosyst Eng | pmid:27878375 |
Herrick KJ et al. | Single-dose infusion of sodium butyrate, but not lactose, increases plasma β-hydroxybutyrate and insulin in lactating dairy cows. | 2017 | J. Dairy Sci. | pmid:27837980 |
Moens F et al. | Lactate- and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans. | 2017 | Int. J. Food Microbiol. | pmid:27810444 |
Zhang C et al. | Differential effect of early antibiotic intervention on bacterial fermentation patterns and mucosal gene expression in the colon of pigs under diets with different protein levels. | 2017 | Appl. Microbiol. Biotechnol. | pmid:27913852 |
Dong W et al. | Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC. | 2017 | J. Endocrinol. | pmid:27799462 |
Meneses-Reyes JC et al. | Biochemical methane potential of oil-extracted microalgae and glycerol in co-digestion with chicken litter. | 2017 | Bioresour. Technol. | pmid:27864134 |
Zhang K et al. | Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. | 2017 | Appl. Biochem. Biotechnol. | pmid:27832512 |
Wang YQ et al. | Enhancement of acetate productivity in a thermophilic (55 °C) hollow-fiber membrane biofilm reactor with mixed culture syngas (H/CO) fermentation. | 2017 | Appl. Microbiol. Biotechnol. | pmid:28110397 |
Chriett S et al. | The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1. | 2017 | Mol. Cell. Endocrinol. | pmid:27619406 |
Kumar G et al. | Microbial responses to various process disturbances in a continuous hydrogen reactor fed with galactose. | 2017 | J. Biosci. Bioeng. | pmid:27614820 |