butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.
To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with butyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Montiel F et al. | Presence of insulin receptors in cultured glial C6 cells. Regulation by butyrate. | 1989 | Biochem. J. | pmid:2930502 |
Hansen JK and Knudsen J | Transacylation as a chain-termination mechanism in fatty acid synthesis by mammalian fatty acid synthetase. Synthesis of butyrate and hexanoate by lactating cow mammary gland fatty acid synthetase. | 1980 | Biochem. J. | pmid:7370014 |
Williamson DH et al. | Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats. | 1980 | Biochem. J. | pmid:7378069 |
Metcalf EC et al. | The effect of ligand presaturation on the interaction of serum albumins with an immobilized Cibacron Blue 3G-A studied by affinity gel electrophoresis. | 1981 | Biochem. J. | pmid:7340816 |
Kottel RH and Fishman WH | Placental alkaline phosphatase isoenzyme expression by the non-HeLa DoT cervical-carcinoma cell line. | 1981 | Biochem. J. | pmid:7342975 |
Ovens MJ et al. | AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. | 2010 | Biochem. J. | pmid:19929853 |
Morrone G et al. | Differential regulation of the expression of interleukin-2 receptor gamma-chain during the in vitro differentiation of human myeloid cells. | 1995 | Biochem. J. | pmid:8948450 |
Higgins PJ and Ryan MP | Biochemical localization of the transformation-sensitive 52 kDa (p52) protein to the substratum contact regions of cultured rat fibroblasts. Butyrate induction, characterization, and quantification of p52 in v-ras transformed cells. | 1989 | Biochem. J. | pmid:2920008 |
Davidson AM and Halestrap AP | Liver mitochondrial pyrophosphate concentration is increased by Ca2+ and regulates the intramitochondrial volume and adenine nucleotide content. | 1987 | Biochem. J. | pmid:2825649 |
Park SH et al. | Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. | 2006 | Biochem. J. | pmid:16584384 |
Porteous JW | Glutamate, glutamine, aspartate, asparagine, glucose and ketone-body metabolism in chick intestinal brush-border cells. | 1980 | Biochem. J. | pmid:7470024 |
Crabtree B et al. | Evidence that the production of acetate in rat hepatocytes is a predominantly cytoplasmic process. | 1989 | Biochem. J. | pmid:2564776 |
Lecona E et al. | Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms. | 2008 | Biochem. J. | pmid:17760565 |
Radom J et al. | Influence of chain length of pyrene fatty acids on their uptake and metabolism by Epstein-Barr-virus-transformed lymphoid cell lines from a patient with multisystemic lipid storage myopathy and from control subjects. | 1990 | Biochem. J. | pmid:2165389 |
Newsholme P et al. | Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages. | 1987 | Biochem. J. | pmid:3593269 |
Benito M et al. | Regulation of ketogenesis during the suckling-weanling transition in the rat. Studies with isolated hepatocytes. | 1979 | Biochem. J. | pmid:226064 |
Malakooti J et al. | Transcriptional regulation of the intestinal luminal Na⺠and Cl⻠transporters. | 2011 | Biochem. J. | pmid:21726200 |
Hendzel MJ and Davie JR | Dynamically acetylated histones of chicken erythrocytes are selectively methylated. | 1991 | Biochem. J. | pmid:1996971 |
Higgins PJ and Ryan MP | p52(PAI-1) and actin expression in butyrate-induced flat revertants of v-ras-transformed rat kidney cells. | 1991 | Biochem. J. | pmid:1953684 |
Higgins PJ et al. | P52PAI-1 gene expression in butyrate-induced flat revertants of v-ras-transformed rat kidney cells: mechanism of induction and involvement in the morphological response. | 1997 | Biochem. J. | pmid:9020877 |
Kondo M et al. | Identification of the mRNA and polypeptide subunit for prostaglandin endoperoxide synthase from mouse mastocytoma P-815 cells. | 1983 | Biochem. J. | pmid:6135418 |
Yarlett N et al. | Respiration of the rumen ciliate Dasytricha ruminantium Schuberg. | 1982 | Biochem. J. | pmid:6293462 |
Brass EP and Beyerinck RA | Effects of propionate and carnitine on the hepatic oxidation of short- and medium-chain-length fatty acids. | 1988 | Biochem. J. | pmid:3134008 |
Helliger W et al. | Alteration in proportions of histone H1 variants during the differentiation of murine erythroleukaemic cells. | 1992 | Biochem. J. | pmid:1471988 |
Garsetti D et al. | Butyric acid-induced differentiation of HL-60 cells increases the expression of a single lysophospholipase. | 1992 | Biochem. J. | pmid:1471998 |
Mollinedo F et al. | Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes. | 1993 | Biochem. J. | pmid:8363564 |
Gurav A et al. | Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions. | 2015 | Biochem. J. | pmid:25984582 |
Vessey DA and Kelley M | Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase. | 2001 | Biochem. J. | pmid:11415461 |
Arts J et al. | Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation. | 1995 | Biochem. J. | pmid:7646441 |
Tang SJ et al. | Analysis of c-fos expression in the butyrate-induced F-98 glioma cell differentiation. | 1995 | Biochem. J. | pmid:7864828 |
Srinivas SR et al. | Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). | 2005 | Biochem. J. | pmid:16104846 |
Izumi T et al. | Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation. | 1995 | Biochem. J. | pmid:7848283 |
Saini K et al. | Induction of carcinoembryonic-antigen-gene expression in human colorectal carcinoma by sodium butyrate. | 1990 | Biochem. J. | pmid:2268282 |
Wakelam MJ and Pette D | The breakdown of phosphatidylinositol in myoblasts stimulated to fuse by the addition of Ca2+. | 1982 | Biochem. J. | pmid:7092841 |
Hodny Z et al. | Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter. | 2000 | Biochem. J. | pmid:10657244 |
ANNISON EF et al. | THE METABOLISM OF ACETIC ACID, PROPIONIC ACID AND BUTYRIC ACID IN SHEEP. | 1963 | Biochem. J. | pmid:14063864 |
Nakada MT et al. | Genetic regulation of beta 2-adrenergic receptors in 3T3-L1 fibroblasts. | 1989 | Biochem. J. | pmid:2549959 |
Halestrap AP and Dunlop JL | Intramitochondrial regulation of fatty acid beta-oxidation occurs between flavoprotein and ubiquinone. A role for changes in the matrix volume. | 1986 | Biochem. J. | pmid:3827814 |
Kim JH et al. | RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation. | 2011 | Biochem. J. | pmid:21413932 |
Zhang D and Nelson DA | Histone acetylation in chicken erythrocytes. Estimation of the percentage of sites actively modified. | 1986 | Biochem. J. | pmid:3827874 |
Izumi H et al. | p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene. | 2003 | Biochem. J. | pmid:12720548 |
Grogan G | Emergent mechanistic diversity of enzyme-catalysed beta-diketone cleavage. | 2005 | Biochem. J. | pmid:15934927 |
Williamson DH and Ellington EV | Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes. | 1975 | Biochem. J. | pmid:1147901 |
Davidson AM and Halestrap AP | Inorganic pyrophosphate is located primarily in the mitochondria of the hepatocyte and increases in parallel with the decrease in light-scattering induced by gluconeogenic hormones, butyrate and ionophore A23187. | 1988 | Biochem. J. | pmid:2845949 |
Burger-van Paassen N et al. | The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. | 2009 | Biochem. J. | pmid:19228118 |
Ardawi MS and Newsholme EA | Fuel utilization in colonocytes of the rat. | 1985 | Biochem. J. | pmid:4074334 |
Ford WC and Candy DJ | The regulation of glycolysis in perfused locust flight muscle. | 1972 | Biochem. J. | pmid:4266373 |
Lee HJ et al. | KLF4 positively regulates human ghrelin expression. | 2009 | Biochem. J. | pmid:19327128 |
Dawson AG | Preparation and some properties of a suspension of fragmented tubules from rat kidney. | 1972 | Biochem. J. | pmid:4352429 |
Zhang DE and Nelson DA | Histone acetylation in chicken erythrocytes. Rates of deacetylation in immature and mature red blood cells. | 1988 | Biochem. J. | pmid:3355515 |
Ferré P et al. | The development of ketogenesis at birth in the rat. | 1978 | Biochem. J. | pmid:747651 |
Madesh M et al. | Butyrate-induced alteration in lipid composition of human colon cell line HT-29. | 1996 | Biochem. Mol. Biol. Int. | pmid:8728094 |
Tong M et al. | Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. | 2006 | Biochem. Pharmacol. | pmid:16844092 |
Mueller A et al. | Diverse signalling by different chemokines through the chemokine receptor CCR5. | 2006 | Biochem. Pharmacol. | pmid:16844091 |
Tune BM and Hsu CY | Toxicity of cephalosporins to fatty acid metabolism in rabbit renal cortical mitochondria. | 1995 | Biochem. Pharmacol. | pmid:7887988 |
Comte J et al. | Reversal of glucose-induced inhibition of newborn rat liver mitochondrial maturation by administration of alkylxanthines at birth. | 1986 | Biochem. Pharmacol. | pmid:3015149 |
Critchfield JW et al. | Modulation of adriamycin accumulation and efflux by flavonoids in HCT-15 colon cells. Activation of P-glycoprotein as a putative mechanism. | 1994 | Biochem. Pharmacol. | pmid:7945444 |
Quivy V and Van Lint C | Regulation at multiple levels of NF-kappaB-mediated transactivation by protein acetylation. | 2004 | Biochem. Pharmacol. | pmid:15313420 |
McBain JA et al. | Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors. | 1997 | Biochem. Pharmacol. | pmid:9214697 |
Bülow R et al. | Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells. | 2007 | Biochem. Pharmacol. | pmid:17889833 |
Mikkelsen IM et al. | Activation of the gamma-glutamyltransferase promoter 2 in the rat colon carcinoma cell line CC531 by histone deacetylase inhibitors is mediated through the Sp1 binding motif. | 2002 | Biochem. Pharmacol. | pmid:12123752 |
Tanaka Y et al. | Enhancement of butyrate-induced differentiation of HT-29 human colon carcinoma cells by 1,25-dihydroxyvitamin D3. | 1989 | Biochem. Pharmacol. | pmid:2688649 |
Gressner AM and Haarmann R | Effect of n-butyrate on the synthesis of sulfated glycosaminoglycans and hyaluronate by rat liver fat-storing cells (Ito cells). | 1988 | Biochem. Pharmacol. | pmid:3178890 |
Chapman AG et al. | Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues. A dose-dependent correlation with changes in brain aspartate and GABA levels in DBA/2 mice. | 1984 | Biochem. Pharmacol. | pmid:6428419 |
Nambi P et al. | Induction of functional beta-adrenergic receptors in rat aortic smooth muscle cells by sodium butyrate. | 1986 | Biochem. Pharmacol. | pmid:3022740 |
Marks DC et al. | Expression of multidrug resistance in response to differentiation in the K562 human leukaemia cell line. | 1995 | Biochem. Pharmacol. | pmid:7646552 |
Schneider FH | Effects of sodium butyrate on mouse neuroblastoma cells in culture. | 1976 | Biochem. Pharmacol. | pmid:988837 |
Jaster R et al. | Inhibition of proliferation but not erythroid differentiation of J2E cells by rapamycin. | 1996 | Biochem. Pharmacol. | pmid:8645341 |
Place RF et al. | HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: down-regulation of proteasome subunit expression stabilizes I kappa B alpha. | 2005 | Biochem. Pharmacol. | pmid:15950952 |
Chen X et al. | Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. | 2017 | Biochem. Pharmacol. | pmid:28684304 |
Dehpour AR et al. | In vitro binding of dantrolene to sarcoplasmic reticulum of rabbit skeletal muscle. | 1982 | Biochem. Pharmacol. | pmid:7082378 |
Wagner S and Roemer K | Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. | 2005 | Biochem. Pharmacol. | pmid:15763542 |
Newman RA et al. | Sodium n-butyrate enhancement of prostaglandin D2 antitumor efficacy. | 1985 | Biochem. Pharmacol. | pmid:4052117 |
Cuff MA and Shirazi-Beechey SP | The importance of butyrate transport to the regulation of gene expression in the colonic epithelium. | 2004 | Biochem. Soc. Trans. | pmid:15506978 |
Moulding DA et al. | Modulation of neutrophil apoptosis by pharmacological agents. | 1996 | Biochem. Soc. Trans. | pmid:8879036 |
Corfield AP et al. | Selection of radioactive precursors for metabolic labelling of mucus glycoproteins. | 1989 | Biochem. Soc. Trans. | pmid:2628065 |
Vanĕk Z et al. | Optimization of streptomycete strains producing polyether and macrolide antibiotics. | 1984 | Biochem. Soc. Trans. | pmid:6489588 |
Daly K et al. | The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis. | 2005 | Biochem. Soc. Trans. | pmid:16042588 |
Coxhead JM et al. | DNA mismatch repair status may influence anti-neoplastic effects of butyrate. | 2005 | Biochem. Soc. Trans. | pmid:16042586 |
Ganapathy V et al. | Biological functions of SLC5A8, a candidate tumour suppressor. | 2005 | Biochem. Soc. Trans. | pmid:15667316 |
Cheung YF and Walsh C | Stereochemical analysis of the elimination reaction catalyzed by D-amino-acid oxidase. | 1976 | Biochemistry | pmid:6045 |
Kassis S | Modulation of the receptor-coupled adenylate cyclase system in HeLa cells by sodium butyrate. | 1985 | Biochemistry | pmid:3000434 |
Perry CA et al. | Analysis of nucleosome assembly and histone exchange using antibodies specific for acetylated H4. | 1993 | Biochemistry | pmid:7504954 |
Honda J et al. | Spectroscopic observation of the intramolecular electron transfer in the photoactivation processes of nitrile hydratase. | 1994 | Biochemistry | pmid:8142355 |
Schlake T et al. | Gene expression within a chromatin domain: the role of core histone hyperacetylation. | 1994 | Biochemistry | pmid:8155635 |
Chou JY and Takahashi S | Control of placental alkaline phosphatase gene expression in HeLa cells: induction of synthesis by prednisolone and sodium butyrate. | 1987 | Biochemistry | pmid:3651399 |
Ugrinova I et al. | In vivo acetylation of HMG1 protein enhances its binding affinity to distorted DNA structures. | 2001 | Biochemistry | pmid:11724579 |
Yamada H and O'Leary MH | Stereochemistry of reactions catalyzed by glutamate decarboxylase. | 1978 | Biochemistry | pmid:341973 |
Cross TA et al. | Ketogenesis in the living rat followed by 13C NMR spectroscopy. | 1984 | Biochemistry | pmid:6529555 |
Klehr D et al. | Scaffold-attached regions (SAR elements) mediate transcriptional effects due to butyrate. | 1992 | Biochemistry | pmid:1554707 |
Malik N and Smulson M | A relationship between nuclear poly(adenosine diphosphate ribosylation) and acetylation posttranslational modifications. 1. Nucleosome studies. | 1984 | Biochemistry | pmid:6089879 |
Smerdon MJ | Rearrangements of chromatin structure in newly repaired regions of deoxyribonucleic acid in human cells treated with sodium butyrate or hydroxyurea. | 1983 | Biochemistry | pmid:6615781 |
Kennedy J et al. | 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. | 2003 | Biochemistry | pmid:14640703 |
Murphy LD et al. | Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. | 1990 | Biochemistry | pmid:1979752 |
Reczek PR et al. | Sodium butyrate induced structural changes in HeLa cell chromatin. | 1982 | Biochemistry | pmid:7074068 |
Chen H et al. | Characterization of two promoters of a rat pregnancy-specific glycoprotein gene. | 1994 | Biochemistry | pmid:8068638 |
Ausio J and van Holde KE | Histone hyperacetylation: its effects on nucleosome conformation and stability. | 1986 | Biochemistry | pmid:3964683 |
D'Anna JA et al. | Histones H1(o)a and H1(o)b are the same as CHO histones H1(III) and H1(IV): new features of H1(o) phosphorylation during the cell cycle. | 1981 | Biochemistry | pmid:7284339 |
Cox GS | Synthesis of the glycoprotein hormone alpha subunit and placental alkaline phosphatase by HeLa cells: effect of tunicamycin, 2-deoxyglucose, and sodium butyrate. | 1981 | Biochemistry | pmid:7295657 |
D'Anna JA et al. | Concentration-dependent effects of sodium butyrate in Chinese hamster cells: cell-cycle progression, inner-histone acetylation, histone H1 dephosphorylation, and induction of an H1-like protein. | 1980 | Biochemistry | pmid:7397096 |