butyric acid

butyric acid is a lipid of Fatty Acyls (FA) class. Butyric acid is associated with abnormalities such as PARKINSON DISEASE, LATE-ONSET, Colitis, Autoimmune Diseases, Inflammatory Bowel Diseases and PARAGANGLIOMAS 2. The involved functions are known as DNA Methylation, Transcription, Genetic, chromatin modification, Gene Expression and Gene Silencing. Butyric acid often locates in Membrane, Chromatin Structure, Chromosomes, viral nucleocapsid location and Ribosomes. The associated genes with butyric acid are Locus, Genes, Dominant, Genes, rRNA, Genome and Chromatin. The related lipids are Butyrates, butyrate, Promega, Butyric Acids and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of butyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with butyric acid?

butyric acid is suspected in Colitis, Ulcerative Colitis, Anemia, Sickle Cell, Thalassemia, PARKINSON DISEASE, LATE-ONSET, Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with butyric acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Colitis D003092 69 associated lipids
Melanoma D008545 69 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Nerve Degeneration D009410 53 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Osteosarcoma D012516 50 associated lipids
Thrombosis D013927 49 associated lipids
Fatty Liver D005234 48 associated lipids
Starvation D013217 47 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Occupational Diseases D009784 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Adenoma D000236 40 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Peritonitis D010538 38 associated lipids
Nervous System Diseases D009422 37 associated lipids
Burns D002056 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Uremia D014511 33 associated lipids
Diarrhea D003967 32 associated lipids
Hypothyroidism D007037 32 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Insulinoma D007340 28 associated lipids
Brain Diseases D001927 27 associated lipids
Per page 10 20 50 100 | Total 149

PubChem Associated disorders and diseases

What pathways are associated with butyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with butyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with butyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with butyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with butyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with butyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with butyric acid

Download all related citations
Per page 10 20 50 100 | Total 7933
Authors Title Published Journal PubMed Link
Chacin J et al. Role of oxalacetate in lipoate effect on frog gastric mucosa. 1976 Am. J. Physiol. pmid:8990
Jentsch TJ et al. Electrical properties of sodium bicarbonate symport in kidney epithelial cells (BSC-1). 1986 Am. J. Physiol. pmid:3024506
Lewandowski ED et al. NMR studies of beta-oxidation and short-chain fatty acid metabolism during recovery of reperfused hearts. 1991 Am. J. Physiol. pmid:1877663
Gullans SR et al. Stimulation of phosphate transport in the proximal tubule by metabolic substrates. 1984 Am. J. Physiol. pmid:6496686
Bourne GA and Baldwin DM Evidence for cAMP as a mediator of gonadotropin secretion from female pituitaries. 1987 Am. J. Physiol. pmid:2820237
Cheng SH et al. Functional activation of the cystic fibrosis trafficking mutant delta F508-CFTR by overexpression. 1995 Am. J. Physiol. pmid:7733303
O'Donnell ME and Horwitz BA Effects of butyrate on ouabain-sensitive respiration of hamster brown adipocytes. 1982 Am. J. Physiol. pmid:7058878
Hollander D and Rim E Effect of luminal constituents on vitamin K1 absorption into thoracic duct lymph. 1978 Am. J. Physiol. pmid:623249
Holtbäck U et al. Neuropeptide Y shifts equilibrium between alpha- and beta-adrenergic tonus in proximal tubule cells. 1998 Am. J. Physiol. pmid:9688998
Hollander D et al. Transport of butyric acid in vascularly perfused anuran small intestine: importance of pH and anion transport. 1986 Am. J. Physiol. pmid:3485924
Vinolo MA et al. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22621868
Etschmann B et al. A vH+-ATPase is present in cultured sheep ruminal epithelial cells. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16825706
Arvans DL et al. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15528251
Musch MW et al. SCFA increase intestinal Na absorption by induction of NHE3 in rat colon and human intestinal C2/bbe cells. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11254495
Kiela PR et al. Regulation of the rat NHE3 gene promoter by sodium butyrate. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11557515
Jørgensen J and Mortensen PB Substrate utilization by intestinal mucosal tissue strips from patients with inflammatory bowel disease. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11447021
Aschenbach JR et al. Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19264953
Shie JL et al. Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11005769
Suply E et al. Butyrate enemas enhance both cholinergic and nitrergic phenotype of myenteric neurons and neuromuscular transmission in newborn rat colon. 2012 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:22492692
Ogawa H et al. Regulated production of the chemokine CCL28 in human colon epithelium. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15246961
Tyagi S et al. Mechanism of n-butyrate uptake in the human proximal colonic basolateral membranes. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11897627
Ramasamy S et al. Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16500920
Alrefai WA et al. Molecular cloning and promoter analysis of downregulated in adenoma (DRA). 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17761837
Saksena S et al. PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19033536
Subramanya SB et al. Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17690171
Fukushima K and Fiocchi C Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15068964
Cremin JD et al. Glucose alleviates ammonia-induced inhibition of short-chain fatty acid metabolism in rat colonic epithelial cells. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637251
Kumar A et al. Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26272259
Amin MR et al. Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17540780
Xu H et al. Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26159698
Parhar K et al. Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16469826
Marcil V et al. Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12121881
Schweigel M et al. Mechanisms of Mg(2+) transport in cultured ruminal epithelial cells. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:10712259
Archer SY et al. The histone deacetylase inhibitor butyrate downregulates cyclin B1 gene expression via a p21/WAF-1-dependent mechanism in human colon cancer cells. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16160080
Borthakur A et al. Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16150873
Borthakur A et al. The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20671196
Srinivas SR et al. Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17855766
Kolar SS et al. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17717041
Cao Y et al. Dietary fiber enhances TGF-β signaling and growth inhibition in the gut. 2011 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:21454444
Saksena S et al. Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20501436
Alrefai WA et al. Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:14525727
Perry MD and Sandle GI Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. 2009 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:19407217
Gaudier E et al. Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15308471
Venkatraman A et al. Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12637250
Grider JR and Piland BE The peristaltic reflex induced by short-chain fatty acids is mediated by sequential release of 5-HT and neuronal CGRP but not BDNF. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16973914
Schweigel M and Martens H Anion-dependent Mg2+ influx and a role for a vacuolar H+-ATPase in sheep ruminal epithelial cells. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12606303
Pawelka AJ and Huizinga JD Induction of rhythmic transient depolarizations associated with waxing and waning of slow wave activity in intestinal smooth muscle. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25540235
Hadjiagapiou C et al. Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 promoter. 2005 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15691871
Yuan L et al. Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. 2010 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:20299602
Sonoyama K et al. Upregulation of activin A gene by butyrate in human colon cancer cell lines. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12540370