| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Kidney Neoplasms | D007680 | 29 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
hesperetin
Hesperetin is a lipid of Polyketides (PK) class. Hesperetin is associated with abnormalities such as Corn of toe, Ischemia, Osteoporosis, Consumption-archaic term for TB and Wiskott-Aldrich Syndrome. The involved functions are known as conjugation, inhibitors, Process, mRNA Expression and Adjudication. Hesperetin often locates in Entire intestinal epithelium, Protoplasm, Membrane, Shoulder and Back. The associated genes with Hesperetin are ABCG2 gene, ABCC2 gene, FATE1 gene, ABCB1 gene and P-glycoprotein 2.
Cross Reference
Introduction
To understand associated biological information of hesperetin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with hesperetin?
hesperetin is suspected in Corn of toe, Ischemia, Osteoporosis, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with hesperetin
PubChem Associated disorders and diseases
What pathways are associated with hesperetin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with hesperetin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with hesperetin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with hesperetin?
There are no associated biomedical information in the current reference collection.
What genes are associated with hesperetin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with hesperetin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with hesperetin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee S et al. | In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones. | 2018 | Molecules | pmid:29932100 |
| Pereira-Caro G et al. | Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. | 2018 | Eur J Nutr | pmid:27722779 |
| González-Alfonso JL et al. | Optimization of Regioselective α-Glucosylation of Hesperetin Catalyzed by Cyclodextrin Glucanotransferase. | 2018 | Molecules | pmid:30400664 |
| Sak K et al. | Suppression of Taxanes Cytotoxicity by Citrus Flavonoid Hesperetin in PPC-1 Human Prostate Cancer Cells. | 2018 | Anticancer Res. | pmid:30396939 |
| Park JH et al. | Hesperetin mitigates acrolein-induced apoptosis in lung cells in vitro and in vivo. | 2018 | Redox Rep. | pmid:30325253 |
| Samie A et al. | Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis. | 2018 | Life Sci. | pmid:30179627 |
| DuranoÄŸlu D et al. | Synthesis of hesperetin-loaded PLGA nanoparticles by two different experimental design methods and biological evaluation of optimized nanoparticles. | 2018 | Nanotechnology | pmid:29972381 |
| Khalaj R et al. | Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism. | 2018 | Int. J. Dev. Neurosci. | pmid:29966739 |
| Baradaran S et al. | Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm. | 2018 | Life Sci. | pmid:30056861 |
| Huang AL et al. | Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives. | 2018 | Int. Immunopharmacol. | pmid:29852476 |
| Ma Y et al. | Metabolism of Phenolic Compounds in LPS-stimulated Raw264.7 Cells Can Impact Their Anti-inflammatory efficacy: Indication of Hesperetin. | 2018 | J. Agric. Food Chem. | pmid:29792322 |
| Nakazawa Y et al. | Effect of hesperetin derivatives on the development of selenite‑induced cataracts in rats. | 2018 | Mol Med Rep | pmid:29845214 |
| Tan YQ et al. | The citrus flavonone hesperetin attenuates the nuclear translocation of aryl hydrocarbon receptor. | 2018 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:29763690 |
| Pelikh O et al. | Nanocrystals for improved dermal drug delivery. | 2018 | Eur J Pharm Biopharm | pmid:29680482 |
| Wang DD et al. | Magnetic molecularly imprinted polymer for the selective extraction of hesperetin from the dried pericarp of Citrus reticulata Blanco. | 2018 | Talanta | pmid:29674047 |
| Vander Dos Santos R et al. | Citrus bioflavonoid, hesperetin, as inhibitor of two thrombin-like snake venom serine proteases isolated from Crotalus simus. | 2018 | Toxicon | pmid:29337219 |
| Kheradmand E et al. | Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease. | 2018 | Biomed. Pharmacother. | pmid:29136946 |
| Elango R et al. | Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells. | 2018 | J Asian Nat Prod Res | pmid:28537448 |
| Meng C et al. | Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR‑γ and Bcl‑2 in model mice. | 2018 | Mol Med Rep | pmid:29115547 |
| Mary Lazer L et al. | Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin. | 2018 | Int. J. Biol. Macromol. | pmid:29032208 |
| Loizzo MR et al. | Ruta chalepensis L. (Rutaceae) leaf extract: chemical composition, antioxidant and hypoglicaemic activities. | 2018 | Nat. Prod. Res. | pmid:28486828 |
| Liu T et al. | Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency. | 2018 | Drug Dev Ind Pharm | pmid:28956456 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| do Nascimento GS et al. | The acute effects of citrus flavanones on the metabolism of glycogen and monosaccharides in the isolated perfused rat liver. | 2018 | Toxicol. Lett. | pmid:29626522 |
| Ding HW et al. | Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent. | 2017 | Fitoterapia | pmid:28774689 |
| Babukumar S et al. | Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters. | 2017 | Arch. Physiol. Biochem. | pmid:28457144 |
| Zareei S et al. | Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study. | 2017 | Life Sci. | pmid:28385612 |
| Noshita T et al. | Structure-activity relationship of flavanone. Anti-degranulation activity of 7-O-substituted hesperetin. | 2017 | Nat. Prod. Res. | pmid:28105859 |
| Zhu C et al. | Hesperetin protects against HO-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells. | 2017 | Biomed. Pharmacother. | pmid:28103505 |
| Coutinho L et al. | Hesperetin-etoposide combinations induce cytotoxicity in U2OS cells: Implications on therapeutic developments for osteosarcoma. | 2017 | DNA Repair (Amst.) | pmid:28063664 |
| Arya A et al. | Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism. | 2017 | Mater Sci Eng C Mater Biol Appl | pmid:27987794 |
| Jung KY et al. | Synthesis and biological evaluation of hesperetin derivatives as agents inducing apoptosis. | 2017 | Bioorg. Med. Chem. | pmid:27840137 |
| Barreca D et al. | Flavanones: Citrus phytochemical with health-promoting properties. | 2017 | Biofactors | pmid:28497905 |
| Xue D et al. | The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration. | 2017 | Oncotarget | pmid:28423500 |
| Menezes PD et al. | Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery. | 2017 | Int J Nanomedicine | pmid:28352176 |
| Chadha K et al. | Is Failure of Cocrystallization Actually a Failure? Eutectic Formation in Cocrystal Screening of Hesperetin. | 2017 | J Pharm Sci | pmid:28456725 |
| Boonpawa R et al. | Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans. | 2017 | Mol Nutr Food Res | pmid:28218440 |
| Li B et al. | Design, Synthesis and Evaluation of Hesperetin Derivatives as Potential Multifunctional Anti-Alzheimer Agents. | 2017 | Molecules | pmid:28672874 |
| Yang YL et al. | Hesperetin-5,7,3'-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice. | 2017 | BMC Pharmacol Toxicol | pmid:28558784 |
| He S et al. | Hesperetin post-treatment prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating PI3K/Akt signaling pathway. | 2017 | Biomed. Pharmacother. | pmid:28531921 |
| Pini F et al. | Bacterial Biosensors for in Vivo Spatiotemporal Mapping of Root Secretion. | 2017 | Plant Physiol. | pmid:28495892 |
| Gong Y et al. | Inhibitory effect of hesperetin on α-glucosidase: Molecular dynamics simulation integrating inhibition kinetics. | 2017 | Int. J. Biol. Macromol. | pmid:28322965 |
| Kumar M et al. | The renoprotective activity of hesperetin in cisplatin induced nephrotoxicity in rats: Molecular and biochemical evidence. | 2017 | Biomed. Pharmacother. | pmid:28320087 |
| Van Rymenant E et al. | Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells. | 2017 | J. Nutr. Biochem. | pmid:27840292 |
| Shagirtha K et al. | Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats. | 2017 | Toxicol Ind Health | pmid:27803291 |
| Pereira-Caro G et al. | Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes. | 2017 | Am. J. Clin. Nutr. | pmid:28747329 |
| Zeng X et al. | Urinary metabolite profiling of flavonoids in Chinese volunteers after consumption of orange juice by UFLC-Q-TOF-MS/MS. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28711784 |
| Sassi A et al. | Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response. | 2017 | Eur. J. Pharmacol. | pmid:28690190 |
| Sammani MS et al. | Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD. | 2017 | Talanta | pmid:28340781 |
| Lopes LAA et al. | Inhibitory effects of flavonoids on biofilm formation by Staphylococcus aureus that overexpresses efflux protein genes. | 2017 | Microb. Pathog. | pmid:28365326 |