Liquiritigenin is a lipid of Polyketides (PK) class. Liquiritigenin is associated with abnormalities such as POSTMENOPAUSAL SYNDROME, Hyperostosis, Diffuse Idiopathic Skeletal, PARAGANGLIOMAS 2, Wiskott-Aldrich Syndrome and Alzheimer's Disease. The involved functions are known as Heterodimerization, Transcription, Genetic, Ligand Binding, Transcriptional Activation and Anabolism. Liquiritigenin often locates in Membrane, Blood, Microsomes, Liver, Microsomes and Body tissue. The associated genes with Liquiritigenin are Candidate Disease Gene, IMPACT gene, TNFSF10 gene, SLC33A1 gene and P4HTM gene. The related lipids are Lipopolysaccharides, pregnenolone sulfate and FuGene. The related experimental models are Xenograft Model.
To understand associated biological information of Liquiritigenin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Liquiritigenin is suspected in POSTMENOPAUSAL SYNDROME, PARAGANGLIOMAS 2, Alzheimer's Disease, Infertility, Central precocious puberty and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Liquiritigenin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Learning Disorders | D007859 | 11 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Hepatitis, Animal | D006520 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic significance of estrogen receptor β agonists in gliomas.' (Sareddy GR et al., 2012).
Transgenic Model are used in the study 'Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.' (Pinto C et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang Z et al. | Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system. | 2018 | Toxicol. Appl. Pharmacol. | pmid:29908794 |
| Liu T et al. | Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin. | 2018 | Eur J Pharm Sci | pmid:30176366 |
| Zhu X et al. | Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-κB and NLRP3 inflammasome pathways. | 2018 | Biomed. Pharmacother. | pmid:30119269 |
| Zhang M et al. | An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study. | 2018 | Drug Test Anal | pmid:28447397 |
| Rahman H et al. | Glycyrrhiza glabra HPLC fractions: identification of Aldehydo Isoophiopogonone and Liquirtigenin having activity against multidrug resistant bacteria. | 2018 | BMC Complement Altern Med | pmid:29720152 |
| Bae GD et al. | Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation. | 2018 | Biomed. Pharmacother. | pmid:29499409 |
| Li Y et al. | Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. | 2018 | Toxicol. Lett. | pmid:29753067 |
| Schüler-Toprak S et al. | Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells. | 2017 | BMC Cancer | pmid:28482871 |
| Biala W et al. | Medicago truncatula ABCG10 is a transporter of 4-coumarate and liquiritigenin in the medicarpin biosynthetic pathway. | 2017 | J. Exp. Bot. | pmid:28369642 |
| Frozza CODS et al. | Antitumor activity of Brazilian red propolis fractions against Hep-2 cancer cell line. | 2017 | Biomed. Pharmacother. | pmid:28514834 |