| MeSH term | MeSH ID | Detail |
|---|---|---|
| Chromosomal Instability | D043171 | 5 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
| Endophthalmitis | D009877 | 12 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Cachexia | D002100 | 21 associated lipids |
| Carcinoma 256, Walker | D002279 | 22 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ramesh N et al. | Phytochemical and antimicrobial studies on Drynaria quercifolia. | 2001 | Fitoterapia | pmid:11731121 |
| Kandhare AD et al. | Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. | 2012 | Fitoterapia | pmid:22343014 |
| Zhang J et al. | Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. | 2012 | Food Chem | pmid:22953882 |
| Li S et al. | Content changes of bitter compounds in 'Guoqing No.1' Satsuma mandarin (Citrus unshiu Marc.) during fruit development of consecutive 3 seasons. | 2014 | Food Chem | pmid:24128570 |
| Yu HY et al. | Anti-platelet effects of yuzu extract and its component. | 2011 | Food Chem. Toxicol. | pmid:22005257 |
| Ramesh E and Alshatwi AA | Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. | 2013 | Food Chem. Toxicol. | pmid:22847135 |
| Chen Y et al. | Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. | 2013 | Food Chem. Toxicol. | pmid:23603004 |
| Sequetto PL et al. | Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis. | 2014 | Food Chem. Toxicol. | pmid:24296135 |
| Li P et al. | Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats. | 2013 | Food Chem. Toxicol. | pmid:23871784 |
| Kumar A et al. | Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. | 2010 | Food Chem. Toxicol. | pmid:19941926 |
| Lee EJ et al. | Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. | 2008 | Food Chem. Toxicol. | pmid:18951945 |
| Vij G et al. | Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant. | 2009 | Fundam Clin Pharmacol | pmid:19469804 |
| Kawaguchi K et al. | Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin. | 2011 | Immunopharmacol Immunotoxicol | pmid:21480758 |
| Luo YL et al. | Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. | 2013 | Inflamm. Res. | pmid:24085318 |
| Jain M and Parmar HS | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. | 2011 | Inflamm. Res. | pmid:21181230 |
| Fuhr U et al. | Grapefruit juice increases oral nimodipine bioavailability. | 1998 | Int J Clin Pharmacol Ther | pmid:9562227 |
| Stohs SJ et al. | Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. | 2011 | Int J Med Sci | pmid:21537493 |
| Choi JS and Han HK | Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. | 2005 | Int J Pharm | pmid:16226412 |
| Choi JS and Shin SC | Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. | 2005 | Int J Pharm | pmid:15725561 |
| Prota L et al. | Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells. | 2011 | Int J Pharm | pmid:21459138 |
| Robbins RC et al. | Ingestion of grapefruit lowers elevated hematocrits in human subjects. | 1988 | Int J Vitam Nutr Res | pmid:3243695 |
| Shin YW et al. | Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. | 1999 | Int J Vitam Nutr Res | pmid:10526779 |
| Yu X et al. | Inhibiting wear particles-induced osteolysis with naringin. | 2013 | Int Orthop | pmid:23111634 |
| Liu Y et al. | Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. | 2011 | Int. Immunopharmacol. | pmid:21640201 |
| Jung UJ et al. | Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16427799 |
| Puri M et al. | Molecular characterization and enzymatic hydrolysis of naringin extracted from kinnow peel waste. | 2011 | Int. J. Biol. Macromol. | pmid:20920523 |
| Huang H et al. | Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway. | 2013 | Int. J. Mol. Med. | pmid:23732220 |
| Chen J et al. | Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells. | 2014 | Int. J. Mol. Med. | pmid:24399619 |
| Prakash A et al. | Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. | 2013 | Int. J. Neurosci. | pmid:23510099 |
| Widmer W | Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. | 2000 Sep-Oct | J AOAC Int | pmid:11048857 |
| Punithavathi VR et al. | Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. | 2008 | J Appl Toxicol | pmid:18344197 |
| Jagetia A et al. | Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival. | 2007 Mar-Apr | J Appl Toxicol | pmid:17177233 |
| Caccamese S and Chillemi R | Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography. | 2010 | J Chromatogr A | pmid:19913235 |
| Wang W et al. | Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. | 2007 | J Chromatogr A | pmid:17383667 |
| Desiderio C et al. | Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography. | 2005 | J Chromatogr A | pmid:16013605 |
| Asztemborska M and Zukowski J | Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods. | 2006 | J Chromatogr A | pmid:16970960 |
| Li C et al. | Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS. | 2010 May-Jun | J Chromatogr Sci | pmid:20515525 |
| Clowers BH and Hill HH | Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498610 |
| Nie YC et al. | Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. | 2012 | J Med Food | pmid:22985397 |
| Kumar A et al. | Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. | 2010 | J Med Food | pmid:20673063 |
| Itoh K et al. | Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice. | 2009 | J Nat Med | pmid:19603253 |
| Li N et al. | Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis. | 2013 | J Orthop Sci | pmid:23553541 |
| Uchiyama N et al. | HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines. | 2008 | J Pharm Biomed Anal | pmid:17532169 |
| Zhou DY et al. | Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. | 2006 | J Pharm Biomed Anal | pmid:16837161 |
| Mello LD et al. | Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)-naringin complex. | 2007 | J Pharm Biomed Anal | pmid:17881180 |
| Kanaze FI et al. | Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. | 2003 | J Pharm Biomed Anal | pmid:12972089 |
| Kanaze FI et al. | A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. | 2004 | J Pharm Biomed Anal | pmid:15351063 |
| Li X et al. | LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. | 2004 | J Pharm Biomed Anal | pmid:14738930 |
| Shirasaka Y et al. | Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. | 2011 | J Pharm Sci | pmid:21520088 |
| Caccamese S et al. | Racemization at C-2 of naringin in sour oranges with increasing maturity determined by chiral high-performance liquid chromatography. | 2007 | J. Agric. Food Chem. | pmid:17417869 |
| Gorinstein S et al. | Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. | 2005 | J. Agric. Food Chem. | pmid:15826081 |
| Lee SJ et al. | Transglycosylation of naringin by Bacillus stearothermophilusMaltogenic amylase to give glycosylated naringin. | 1999 | J. Agric. Food Chem. | pmid:10552702 |
| Poulaert M et al. | Grapefruit juices impair the bioaccessibility of β-carotene from orange-fleshed sweet potato but not its intestinal uptake by Caco-2 cells. | 2012 | J. Agric. Food Chem. | pmid:22221263 |
| Tsai TH | Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. | 2002 | J. Agric. Food Chem. | pmid:12405759 |
| Ishii K et al. | Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. | 2000 | J. Agric. Food Chem. | pmid:10637051 |
| Jung DM et al. | Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy. | 2000 | J. Agric. Food Chem. | pmid:10691648 |
| Chen Y et al. | Purification and characterization of a naringinase from Aspergillus aculeatus JMUdb058. | 2013 | J. Agric. Food Chem. | pmid:23289582 |
| Yoo KM et al. | Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. | 2004 | J. Agric. Food Chem. | pmid:15366841 |
| Ni H et al. | Development and evaluation of an HPLC method for accurate determinations of enzyme activities of naringinase complex. | 2013 | J. Agric. Food Chem. | pmid:24070201 |
| Cohen MF and Yamasaki H | Flavonoid-induced expression of a symbiosis-related gene in the cyanobacterium Nostoc punctiforme. | 2000 | J. Bacteriol. | pmid:10913102 |
| ElÃades LA et al. | α-L-rhamnosidase and β-D-glucosidase activities in fungal strains isolated from alkaline soils and their potential in naringin hydrolysis. | 2011 | J. Basic Microbiol. | pmid:21952976 |
| Rajadurai M and Prince PS | Preventive effect of naringin on cardiac mitochondrial enzymes during isoproterenol-induced myocardial infarction in rats: a transmission electron microscopic study. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17994577 |
| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in Wistar rats. | 2006 | J. Biochem. Mol. Toxicol. | pmid:16906524 |
| Gordon PB et al. | Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. | 1995 | J. Biol. Chem. | pmid:7890712 |
| Larsen AK et al. | Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes. | 2002 | J. Biol. Chem. | pmid:12095991 |
| Katsoura MH et al. | Use of ionic liquids as media for the biocatalytic preparation of flavonoid derivatives with antioxidant potency. | 2006 | J. Biotechnol. | pmid:16457903 |
| Xulu S and Oroma Owira PM | Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes. | 2012 | J. Cardiovasc. Pharmacol. | pmid:21964158 |
| Choe SC et al. | Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. | 2001 | J. Cardiovasc. Pharmacol. | pmid:11707699 |
| Laska M et al. | Gustatory responsiveness to six bitter tastants in three species of nonhuman primates. | 2009 | J. Chem. Ecol. | pmid:19399556 |
| Mouly P et al. | Column liquid chromatographic determination of flavanone glycosides in Citrus. Application to grapefruit and sour orange juice adulterations. | 1993 | J. Chromatogr. | pmid:8486744 |
| Ding L et al. | Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17689302 |
| Mahmoud AM et al. | Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. | 2012 Nov-Dec | J. Diabetes Complicat. | pmid:22809898 |
| Mangan RL et al. | Grapefruit as a host for the West Indian fruit fly (Diptera: Tephritidae). | 2011 | J. Econ. Entomol. | pmid:21404839 |
| Uckoo RM et al. | Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. | 2012 | J. Food Sci. | pmid:22957912 |
| Ni H et al. | Characterization and preparation of Aspergillus niger naringinase for debittering citrus juice. | 2012 | J. Food Sci. | pmid:22122507 |
| Rojas NL et al. | Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21221705 |
| Muller GW et al. | Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1. | 1992 | J. Med. Chem. | pmid:1588556 |
| Go YH et al. | Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids. | 2007 | J. Microbiol. Biotechnol. | pmid:18062236 |
| Nunes MA et al. | High-affinity water-soluble system for efficient naringinase immobilization in polyvinyl alcohol-dimethyl sulfoxide lens-shaped particles. | 2012 | J. Mol. Recognit. | pmid:23108618 |
| Rundén E et al. | Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. | 1998 | J. Neurosci. | pmid:9736650 |
| Demonty I et al. | The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. | 2010 | J. Nutr. | pmid:20660284 |
| Jung UJ et al. | The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. | 2004 | J. Nutr. | pmid:15465737 |
| Chanet A et al. | Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. | 2012 | J. Nutr. Biochem. | pmid:21684135 |
| Zhou X et al. | Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. | 2010 | J. Orthop. Res. | pmid:19824055 |
| Wong RW and Rabie AB | Effect of naringin on bone cells. | 2006 | J. Orthop. Res. | pmid:16944474 |
| Zhang L et al. | Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. | 2006 | J. Pharm. Pharmacol. | pmid:16945185 |
| Lassoued MA et al. | Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs. | 2012 | J. Pharm. Pharmacol. | pmid:22420660 |
| Shirasaka Y et al. | Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19779132 |
| Kanno S et al. | Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. | 2003 | J. Pharmacol. Sci. | pmid:12832847 |
| Zhao J et al. | Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis. | 2013 | J. Pharmacol. Sci. | pmid:23739595 |
| Johnston A and Holt DW | Effect of grapefruit juice on blood cyclosporin concentration. | 1995 | Lancet | pmid:7603196 |
| Elinbaum S et al. | Production of Aspergillus terreus alpha-L-rhamnosidase by solid state fermentation. | 2002 | Lett. Appl. Microbiol. | pmid:11849496 |
| Scaroni E et al. | Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi. | 2002 | Lett. Appl. Microbiol. | pmid:12028430 |
| Aggarwal A et al. | Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. | 2010 | Life Sci. | pmid:20433854 |
| Jagetia GC and Reddy TK | Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. | 2005 | Life Sci. | pmid:15936352 |
| Kanno S et al. | Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. | 2006 | Life Sci. | pmid:16137700 |
| Jeon SM et al. | Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. | 2001 | Life Sci. | pmid:11720089 |
| Seo HJ et al. | Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. | 2003 | Life Sci. | pmid:12798418 |
| Kanno S et al. | Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. | 2004 | Life Sci. | pmid:15135655 |
| Kim HJ et al. | Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. | 2004 | Life Sci. | pmid:14738906 |