NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
Miyazaki N et al. | Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats. | 2013 | Drug Metab. Pharmacokinet. | pmid:23419354 |
Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. | 2011 | Drug Metab. Pharmacokinet. | pmid:21206133 |
Lambev I et al. | [Antiexudative effect of naringin in experimental pulmonary edema and peritonitis]. | 1980 | Eksp Med Morfol | pmid:7460808 |
Oki K et al. | The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. | 2012 | Endocrinology | pmid:22798349 |
Liu M et al. | Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787720 |
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Runkel M et al. | Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man. | 1996 | Eur. J. Clin. Pharmacol. | pmid:8737764 |
Runkel M et al. | The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in human. | 1997 | Eur. J. Clin. Pharmacol. | pmid:9476043 |
Gaur V et al. | Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. | 2009 | Eur. J. Pharmacol. | pmid:19577560 |
Wu JB et al. | Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. | 2008 | Eur. J. Pharmacol. | pmid:18495116 |
Kawaguchi K et al. | Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. | 1999 | Eur. J. Pharmacol. | pmid:10193661 |
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Pari L and Amudha K | Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. | 2011 | Eur. J. Pharmacol. | pmid:20950607 |
Zhang P et al. | Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. | 2009 | Eur. J. Pharmacol. | pmid:19326565 |
Walker AL et al. | Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. | 2011 | Exp. Hematol. | pmid:21256917 |
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Ang ES et al. | Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. | 2011 | FEBS Lett. | pmid:21835177 |
Iqbal MF and Zhu WY | Bioactivation of flavonoid diglycosides by chicken cecal bacteria. | 2009 | FEMS Microbiol. Lett. | pmid:19473248 |
Manzanares P et al. | Purification and characterization of an alpha-L-rhamnosidase from Aspergillus niger. | 1997 | FEMS Microbiol. Lett. | pmid:9435109 |