NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Zhang J and Brodbelt JS | Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. | 2004 | Analyst | pmid:15565223 |
Jeon SM et al. | Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. | 2004 | Clin Nutr | pmid:15380892 |
Singh D et al. | Protective effect of naringin, a bioflavonoid on ferric nitrilotriacetate-induced oxidative renal damage in rat kidney. | 2004 | Toxicology | pmid:15297014 |
Singh D et al. | Protective effect of naringin, a bioflavonoid on glycerol-induced acute renal failure in rat kidney. | 2004 | Toxicology | pmid:15297029 |
Jagetia GC et al. | Influence of naringin on ferric iron induced oxidative damage in vitro. | 2004 | Clin. Chim. Acta | pmid:15313158 |
Yoo KM et al. | Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. | 2004 | J. Agric. Food Chem. | pmid:15366841 |
Møller MT et al. | Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. | 2004 | Toxicol. Sci. | pmid:15342961 |
Kanaze FI et al. | A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. | 2004 | J Pharm Biomed Anal | pmid:15351063 |
Singh D and Chopra K | The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. | 2004 | Pharmacol. Res. | pmid:15177308 |
Kanno S et al. | Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. | 2004 | Life Sci. | pmid:15135655 |
Kim HJ et al. | Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. | 2004 | Life Sci. | pmid:14738906 |
Li X et al. | LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. | 2004 | J Pharm Biomed Anal | pmid:14738930 |
Giannuzzo AN et al. | Supercritical fluid extraction of naringin from the peel of Citrus paradisi. | 2003 Jul-Aug | Phytochem Anal | pmid:12892417 |
Kanno S et al. | Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. | 2003 | J. Pharmacol. Sci. | pmid:12832847 |
Seo HJ et al. | Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. | 2003 | Life Sci. | pmid:12798418 |
Kanaze FI et al. | Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. | 2003 | J Pharm Biomed Anal | pmid:12972089 |
Møller MT et al. | Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. | 2003 | Biochem. J. | pmid:12697024 |
Hermans K et al. | Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome. | 2003 | Am. J. Med. | pmid:12727589 |
Caccamese S et al. | Chiral HPLC separation and CD spectra of the C-2 diastereomers of naringin in grapefruit during maturation. | 2003 | Chirality | pmid:12923803 |
Jagetia GC et al. | Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. | 2003 | Mutagenesis | pmid:12840107 |
Jung UJ et al. | Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. | 2003 | Clin Nutr | pmid:14613759 |
Martearena MR et al. | Synthesis of alkyl-alpha-L-rhamnosides by water soluble alcohols enzymatic glycosylation. | 2003 | Bioresour. Technol. | pmid:14575952 |
Elinbaum S et al. | Production of Aspergillus terreus alpha-L-rhamnosidase by solid state fermentation. | 2002 | Lett. Appl. Microbiol. | pmid:11849496 |
Jeon SM et al. | Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. | 2002 | Clin. Chim. Acta | pmid:11814474 |
Jagetia GC and Reddy TK | The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. | 2002 | Mutat. Res. | pmid:12160890 |
Larsen AK et al. | Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes. | 2002 | J. Biol. Chem. | pmid:12095991 |
Ohtani M et al. | [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine]. | 2002 | Yakugaku Zasshi | pmid:12040751 |
Scaroni E et al. | Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi. | 2002 | Lett. Appl. Microbiol. | pmid:12028430 |
Tsai TH | Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. | 2002 | J. Agric. Food Chem. | pmid:12405759 |
Soria F and Ellenrieder G | Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224626 |
Li XL et al. | [Determination of hesperidin and naringin in Fructus Aurantii Immaturus and Fructus Aurantii by reversed-phase high performance liquid chromatography]. | 2002 | Se Pu | pmid:12683015 |
Berven G et al. | Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. | 2001 Feb-Mar | Toxicon | pmid:10978754 |
Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
Jeon SM et al. | Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. | 2001 | Life Sci. | pmid:11720089 |
Choe SC et al. | Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. | 2001 | J. Cardiovasc. Pharmacol. | pmid:11707699 |
Ramesh N et al. | Phytochemical and antimicrobial studies on Drynaria quercifolia. | 2001 | Fitoterapia | pmid:11731121 |
Choi MS et al. | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. | 2001 | Ann. Nutr. Metab. | pmid:11585976 |
Alvarez-González I et al. | Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamily. | 2001 | Mutat. Res. | pmid:11506811 |
da Silva RR et al. | [Hypocholesterolemic effect of naringin and rutin flavonoids]. | 2001 | Arch Latinoam Nutr | pmid:11795241 |
Widmer W | Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. | 2000 Sep-Oct | J AOAC Int | pmid:11048857 |
Akiyama T et al. | Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129606 |
Hu Y et al. | [Pharmacognostical identification of one Rhizoma Drynariae habitually used species from Yunnan]. | 2000 | Zhong Yao Cai | pmid:12575083 |
Xiao M et al. | [Determination of naringin and synephrine in fructus aurantii from different habitats by HPLC]. | 2000 | Zhong Yao Cai | pmid:12575153 |
Ishii K et al. | Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. | 2000 | J. Agric. Food Chem. | pmid:10637051 |
Bailey DG et al. | Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. | 2000 | Clin. Pharmacol. Ther. | pmid:11103749 |
Cohen MF and Yamasaki H | Flavonoid-induced expression of a symbiosis-related gene in the cyanobacterium Nostoc punctiforme. | 2000 | J. Bacteriol. | pmid:10913102 |
Russo A et al. | Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. | 2000 | Cell Biol. Toxicol. | pmid:10917564 |
Blankson H et al. | Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. | 2000 | Cell Death Differ. | pmid:10918448 |
Jung DM et al. | Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy. | 2000 | J. Agric. Food Chem. | pmid:10691648 |
Zverlov VV et al. | The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. | 2000 | Mol. Microbiol. | pmid:10632887 |
Kawaguchi K et al. | Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. | 1999 | Eur. J. Pharmacol. | pmid:10193661 |
Shin YW et al. | Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. | 1999 | Int J Vitam Nutr Res | pmid:10526779 |
Lee SJ et al. | Transglycosylation of naringin by Bacillus stearothermophilusMaltogenic amylase to give glycosylated naringin. | 1999 | J. Agric. Food Chem. | pmid:10552702 |
Seto E et al. | Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. | 1999 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10386788 |
Li J et al. | [A review of the study on Drynaria fortunei]. | 1999 | Zhong Yao Cai | pmid:12903628 |
Fuhr U et al. | Grapefruit juice increases oral nimodipine bioavailability. | 1998 | Int J Clin Pharmacol Ther | pmid:9562227 |
Rundén E et al. | Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. | 1998 | J. Neurosci. | pmid:9736650 |
Wang Y and Li J | [Qualitative identification and quantitative determination of naringin in rhizoma Drynariae by TLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599350 |
Bailey DG et al. | Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans. | 1998 | Clin. Pharmacol. Ther. | pmid:9757148 |
Manzanares P et al. | Purification and characterization of an alpha-L-rhamnosidase from Aspergillus niger. | 1997 | FEMS Microbiol. Lett. | pmid:9435109 |
Kawaguchi K et al. | Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9028038 |
Runkel M et al. | The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in human. | 1997 | Eur. J. Clin. Pharmacol. | pmid:9476043 |
Drewnowski A et al. | Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil. | 1997 | Am. J. Clin. Nutr. | pmid:9250119 |
Kometani T et al. | Synthesis of neohesperidin glycosides and naringin glycosides by cyclodextrin glucanotransferase from an alkalophilic Bacillus species. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8829532 |
Runkel M et al. | Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man. | 1996 | Eur. J. Clin. Pharmacol. | pmid:8737764 |
Johnston A and Holt DW | Effect of grapefruit juice on blood cyclosporin concentration. | 1995 | Lancet | pmid:7603196 |
Gordon PB et al. | Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. | 1995 | J. Biol. Chem. | pmid:7890712 |
Bailey DG et al. | Grapefruit juice and drugs. How significant is the interaction? | 1994 | Clin Pharmacokinet | pmid:8162660 |
Zhou FR and Zhang ZQ | [Quality evaluation of 3 kinds of rhizoma Drynariae]. | 1994 | Zhongguo Zhong Yao Za Zhi | pmid:7945861 |
Zhou YH and Zou HJ | [Studies on chemical constituents of naringin]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8011085 |
Bailey DG et al. | Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. | 1993 | Clin. Pharmacol. Ther. | pmid:8275614 |
Bailey DG et al. | Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin. | 1993 | Clin. Pharmacol. Ther. | pmid:8513655 |
Yao QS and Chiou GC | Inhibition of crystallins-induced inflammation in rabbit eyes with five phytogenic compounds. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503279 |
Mouly P et al. | Column liquid chromatographic determination of flavanone glycosides in Citrus. Application to grapefruit and sour orange juice adulterations. | 1993 | J. Chromatogr. | pmid:8486744 |
Muller GW et al. | Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1. | 1992 | J. Med. Chem. | pmid:1588556 |
Arnao MB et al. | An enzymatic colorimetric method for measuring naringin using 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS) in the presence of peroxidase. | 1990 | Anal. Biochem. | pmid:2339789 |
Robbins RC et al. | Ingestion of grapefruit lowers elevated hematocrits in human subjects. | 1988 | Int J Vitam Nutr Res | pmid:3243695 |
Ding XF | [Strains and quality of zhiqiao in Jiangxi Province]. | 1986 | Zhong Yao Tong Bao | pmid:2944652 |
Wilhelmi G and Maier R | [Test of potential antiarthritic drugs on spontaneous arthritis of mice]. | 1983 Jul-Aug | Z Rheumatol | pmid:6689102 |
Kempler GM | Production of flavor compounds by microorganisms. | 1983 | Adv. Appl. Microbiol. | pmid:6650264 |
Lambev I et al. | Flavonoids with antioxidant action (naringin and rutin) and the release of mastocytic and nonmastocytic histamine. | 1980 | Acta Physiol Pharmacol Bulg | pmid:6159775 |
Lambev I et al. | [Antiexudative effect of naringin in experimental pulmonary edema and peritonitis]. | 1980 | Eksp Med Morfol | pmid:7460808 |
KEENAN GL | The occurrence of crystalline naringin on grapefruit rind. | 1946 | Science | pmid:20995510 |