NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kandhare AD et al. | Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. | 2012 | Fitoterapia | pmid:22343014 |
Zhang J et al. | Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. | 2012 | Food Chem | pmid:22953882 |
Li S et al. | Content changes of bitter compounds in 'Guoqing No.1' Satsuma mandarin (Citrus unshiu Marc.) during fruit development of consecutive 3 seasons. | 2014 | Food Chem | pmid:24128570 |
Yu HY et al. | Anti-platelet effects of yuzu extract and its component. | 2011 | Food Chem. Toxicol. | pmid:22005257 |
Ramesh E and Alshatwi AA | Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. | 2013 | Food Chem. Toxicol. | pmid:22847135 |
Chen Y et al. | Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. | 2013 | Food Chem. Toxicol. | pmid:23603004 |
Sequetto PL et al. | Naringin accelerates the regression of pre-neoplastic lesions and the colorectal structural reorganization in a murine model of chemical carcinogenesis. | 2014 | Food Chem. Toxicol. | pmid:24296135 |
Li P et al. | Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats. | 2013 | Food Chem. Toxicol. | pmid:23871784 |
Kumar A et al. | Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. | 2010 | Food Chem. Toxicol. | pmid:19941926 |
Lee EJ et al. | Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. | 2008 | Food Chem. Toxicol. | pmid:18951945 |
Vij G et al. | Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant. | 2009 | Fundam Clin Pharmacol | pmid:19469804 |
Kawaguchi K et al. | Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin. | 2011 | Immunopharmacol Immunotoxicol | pmid:21480758 |
Luo YL et al. | Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. | 2013 | Inflamm. Res. | pmid:24085318 |
Jain M and Parmar HS | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. | 2011 | Inflamm. Res. | pmid:21181230 |
Fuhr U et al. | Grapefruit juice increases oral nimodipine bioavailability. | 1998 | Int J Clin Pharmacol Ther | pmid:9562227 |
Stohs SJ et al. | Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. | 2011 | Int J Med Sci | pmid:21537493 |
Choi JS and Han HK | Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. | 2005 | Int J Pharm | pmid:16226412 |
Choi JS and Shin SC | Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. | 2005 | Int J Pharm | pmid:15725561 |
Prota L et al. | Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells. | 2011 | Int J Pharm | pmid:21459138 |
Robbins RC et al. | Ingestion of grapefruit lowers elevated hematocrits in human subjects. | 1988 | Int J Vitam Nutr Res | pmid:3243695 |
Shin YW et al. | Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. | 1999 | Int J Vitam Nutr Res | pmid:10526779 |
Yu X et al. | Inhibiting wear particles-induced osteolysis with naringin. | 2013 | Int Orthop | pmid:23111634 |
Liu Y et al. | Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. | 2011 | Int. Immunopharmacol. | pmid:21640201 |
Jung UJ et al. | Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16427799 |
Puri M et al. | Molecular characterization and enzymatic hydrolysis of naringin extracted from kinnow peel waste. | 2011 | Int. J. Biol. Macromol. | pmid:20920523 |
Huang H et al. | Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway. | 2013 | Int. J. Mol. Med. | pmid:23732220 |
Chen J et al. | Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells. | 2014 | Int. J. Mol. Med. | pmid:24399619 |
Prakash A et al. | Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. | 2013 | Int. J. Neurosci. | pmid:23510099 |
Widmer W | Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. | 2000 Sep-Oct | J AOAC Int | pmid:11048857 |
Punithavathi VR et al. | Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. | 2008 | J Appl Toxicol | pmid:18344197 |
Jagetia A et al. | Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival. | 2007 Mar-Apr | J Appl Toxicol | pmid:17177233 |
Caccamese S and Chillemi R | Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography. | 2010 | J Chromatogr A | pmid:19913235 |
Wang W et al. | Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. | 2007 | J Chromatogr A | pmid:17383667 |
Desiderio C et al. | Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography. | 2005 | J Chromatogr A | pmid:16013605 |
Asztemborska M and Zukowski J | Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods. | 2006 | J Chromatogr A | pmid:16970960 |
Li C et al. | Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS. | 2010 May-Jun | J Chromatogr Sci | pmid:20515525 |
Clowers BH and Hill HH | Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498610 |
Nie YC et al. | Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. | 2012 | J Med Food | pmid:22985397 |
Kumar A et al. | Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. | 2010 | J Med Food | pmid:20673063 |
Itoh K et al. | Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice. | 2009 | J Nat Med | pmid:19603253 |
Li N et al. | Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis. | 2013 | J Orthop Sci | pmid:23553541 |
Uchiyama N et al. | HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines. | 2008 | J Pharm Biomed Anal | pmid:17532169 |
Zhou DY et al. | Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. | 2006 | J Pharm Biomed Anal | pmid:16837161 |
Mello LD et al. | Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)-naringin complex. | 2007 | J Pharm Biomed Anal | pmid:17881180 |
Kanaze FI et al. | Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. | 2003 | J Pharm Biomed Anal | pmid:12972089 |
Kanaze FI et al. | A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. | 2004 | J Pharm Biomed Anal | pmid:15351063 |
Li X et al. | LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. | 2004 | J Pharm Biomed Anal | pmid:14738930 |
Shirasaka Y et al. | Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. | 2011 | J Pharm Sci | pmid:21520088 |
Poulaert M et al. | Grapefruit juices impair the bioaccessibility of β-carotene from orange-fleshed sweet potato but not its intestinal uptake by Caco-2 cells. | 2012 | J. Agric. Food Chem. | pmid:22221263 |