NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Gong HL et al. | Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats. | 2012 | Chin J Integr Med | pmid:22936325 |
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Liu Y et al. | Naringin inhibits chemokine production in an LPS-induced RAW 264.7 macrophage cell line. | 2012 | Mol Med Rep | pmid:22965302 |
Zhang J et al. | Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. | 2012 | Food Chem | pmid:22953882 |
Nie YC et al. | Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. | 2012 | J Med Food | pmid:22985397 |
Poulaert M et al. | Grapefruit juices impair the bioaccessibility of β-carotene from orange-fleshed sweet potato but not its intestinal uptake by Caco-2 cells. | 2012 | J. Agric. Food Chem. | pmid:22221263 |
Pu P et al. | Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. | 2012 | Arch. Biochem. Biophys. | pmid:22198281 |
Camargo CA et al. | Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcoma. | 2012 | Anticancer Res. | pmid:22213297 |
Wang D et al. | Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease. | 2012 | Pharmacol. Biochem. Behav. | pmid:22741174 |
Maratha SR and Mahadevan N | Memory enhancing activity of naringin in unstressed and stressed mice: possible cholinergic and nitriergic modulation. | 2012 | Neurochem. Res. | pmid:22821418 |
Liu MH et al. | Study on impurities in naringin extracted from Citrus grandis 'tomentosa'. | 2012 | Zhong Yao Cai | pmid:22734411 |
Oki K et al. | The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. | 2012 | Endocrinology | pmid:22798349 |
Liu Y et al. | [Transdermal behavior of effective constituents in xuanbi gel plaster]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22803360 |
Nie YC et al. | Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. | 2012 | Eur. J. Pharmacol. | pmid:22766066 |
Lassoued MA et al. | Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs. | 2012 | J. Pharm. Pharmacol. | pmid:22420660 |
Rong W et al. | Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. | 2012 | Neurochem. Res. | pmid:22453521 |
Kwatra D et al. | Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism. | 2012 | Mol. Pharm. | pmid:22676443 |
Liu M et al. | Metabolism and excretion studies of oral administered naringin, a putative antitussive, in rats and dogs. | 2012 | Biopharm Drug Dispos | pmid:22374702 |
Parmar HS et al. | DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. | 2012 | Diabetes Res. Clin. Pract. | pmid:22410395 |
Luo Z et al. | Effects of pH on the ability of flavonoids to act as Pickering emulsion stabilizers. | 2012 | Colloids Surf B Biointerfaces | pmid:22197223 |
Shaik N et al. | Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. | 2012 | Cell. Physiol. Biochem. | pmid:22854627 |
Huang W et al. | Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus aurantii-type formulae. | 2012 | Pharmazie | pmid:22888512 |
Gopinath K and Sudhandiran G | Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. | 2012 | Neuroscience | pmid:22871521 |
Wang JN et al. | Population pharmacokinetics of naringin in total flavonoids of Drynaria fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis. | 2012 | Chin J Integr Med | pmid:23239001 |
Nunes MA et al. | High-affinity water-soluble system for efficient naringinase immobilization in polyvinyl alcohol-dimethyl sulfoxide lens-shaped particles. | 2012 | J. Mol. Recognit. | pmid:23108618 |
Yilmaz D et al. | Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. | 2012 | Toxicol Ind Health | pmid:21636685 |
Chanet A et al. | Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. | 2012 | J. Nutr. Biochem. | pmid:21684135 |
Ni H et al. | Characterization and preparation of Aspergillus niger naringinase for debittering citrus juice. | 2012 | J. Food Sci. | pmid:22122507 |