NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. | 2007 | Toxicology | pmid:17188415 |
Singh D et al. | Protective effect of naringin, a bioflavonoid on glycerol-induced acute renal failure in rat kidney. | 2004 | Toxicology | pmid:15297029 |
Berven G et al. | Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. | 2001 Feb-Mar | Toxicon | pmid:10978754 |
Hudzenko OV and Varbanets' LD | [Substrate specificity of Cryptococcus albidus and Eupenicillium erubescens alpha-L-rhamnosidases]. | 2013 Sep-Oct | Ukr Biokhim Zh (1999) | pmid:24479319 |
Gong HL et al. | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components. | 2009 | World J. Gastroenterol. | pmid:20014465 |
Luo R et al. | Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies. | 2009 | Yakugaku Zasshi | pmid:19952535 |
Li K et al. | Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography. | 2006 | Yakugaku Zasshi | pmid:17077620 |
Ohtani M et al. | [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine]. | 2002 | Yakugaku Zasshi | pmid:12040751 |
Kubo M et al. | [History and therapeutic evaluation of Citrus hassaku HORT. Tanaka]. | 2004 | Yakushigaku Zasshi | pmid:16025659 |
Wilhelmi G and Maier R | [Test of potential antiarthritic drugs on spontaneous arthritis of mice]. | 1983 Jul-Aug | Z Rheumatol | pmid:6689102 |
Ali MM et al. | Modulation of anticancer drug-induced P-glycoprotein expression by naringin. | 2009 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:19323275 |
Hu QY et al. | [Traditional Chinese medicine Drynaria fortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175240 |
Chen JC et al. | [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice]. | 2009 | Zhong Xi Yi Jie He Xue Bao | pmid:19583936 |
Viswanatha GL et al. | Amelioration of immobilization stress-induced biochemical and behavioral alterations and mitochondrial dysfunction by naringin in mice: possible mechanism of nitric oxide modulation. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088593 |
Liu MH et al. | Study on impurities in naringin extracted from Citrus grandis 'tomentosa'. | 2012 | Zhong Yao Cai | pmid:22734411 |
Hu Y et al. | [Pharmacognostical identification of one Rhizoma Drynariae habitually used species from Yunnan]. | 2000 | Zhong Yao Cai | pmid:12575083 |
Xiao M et al. | [Determination of naringin and synephrine in fructus aurantii from different habitats by HPLC]. | 2000 | Zhong Yao Cai | pmid:12575153 |
Li J et al. | [A review of the study on Drynaria fortunei]. | 1999 | Zhong Yao Cai | pmid:12903628 |
Ding XF | [Strains and quality of zhiqiao in Jiangxi Province]. | 1986 | Zhong Yao Tong Bao | pmid:2944652 |
Yao QS and Chiou GC | Inhibition of crystallins-induced inflammation in rabbit eyes with five phytogenic compounds. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503279 |
Ding P et al. | [Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19873788 |
Qu QL et al. | [Identification of jizhi syrup using HPLC fingerprint]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17608218 |
Zhang LH et al. | [Optimal extraction of Dingxiang jiangqi granules]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309666 |
Huang ZF et al. | [Study on quality control of effective fraction in qixue bingzhi decoction]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011278 |
Zhou YH and Zou HJ | [Studies on chemical constituents of naringin]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8011085 |
Liu ZL et al. | [Determination of three chemical components in Fructus aurantii immaturus]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17087081 |
Zhou FR and Zhang ZQ | [Quality evaluation of 3 kinds of rhizoma Drynariae]. | 1994 | Zhongguo Zhong Yao Za Zhi | pmid:7945861 |
Wang Y and Li J | [Qualitative identification and quantitative determination of naringin in rhizoma Drynariae by TLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599350 |
Xu C et al. | [Study on technology in preparation of Fructus Auranti extract]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22308686 |
Liu Y et al. | [Transdermal behavior of effective constituents in xuanbi gel plaster]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22803360 |
Zhai YK et al. | [Effects of naringin on proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596885 |
Xu D and Cheng K | [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21473151 |
Wang J et al. | [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20862961 |