NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bailey DG et al. | Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. | 1993 | Clin. Pharmacol. Ther. | pmid:8275614 |
Bailey DG et al. | Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin. | 1993 | Clin. Pharmacol. Ther. | pmid:8513655 |
Bailey DG et al. | Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. | 2000 | Clin. Pharmacol. Ther. | pmid:11103749 |
Bailey DG et al. | Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans. | 1998 | Clin. Pharmacol. Ther. | pmid:9757148 |
Bailey DG et al. | Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. | 2007 | Clin. Pharmacol. Ther. | pmid:17301733 |
Luo Z et al. | Effects of pH on the ability of flavonoids to act as Pickering emulsion stabilizers. | 2012 | Colloids Surf B Biointerfaces | pmid:22197223 |
Parmar HS et al. | DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. | 2012 | Diabetes Res. Clin. Pract. | pmid:22410395 |
Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. | 2011 | Drug Metab. Pharmacokinet. | pmid:21206133 |
Miyazaki N et al. | Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats. | 2013 | Drug Metab. Pharmacokinet. | pmid:23419354 |