NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lambev I et al. | Flavonoids with antioxidant action (naringin and rutin) and the release of mastocytic and nonmastocytic histamine. | 1980 | Acta Physiol Pharmacol Bulg | pmid:6159775 |
Kempler GM | Production of flavor compounds by microorganisms. | 1983 | Adv. Appl. Microbiol. | pmid:6650264 |
Wei M et al. | Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model. | 2007 | Am. J. Chin. Med. | pmid:17708632 |
Drewnowski A et al. | Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil. | 1997 | Am. J. Clin. Nutr. | pmid:9250119 |
Hermans K et al. | Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome. | 2003 | Am. J. Med. | pmid:12727589 |
Little TJ et al. | Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19535679 |
Arnao MB et al. | An enzymatic colorimetric method for measuring naringin using 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS) in the presence of peroxidase. | 1990 | Anal. Biochem. | pmid:2339789 |
Zhang J and Brodbelt JS | Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. | 2004 | Analyst | pmid:15565223 |
Bodas R et al. | The liver antioxidant status of fattening lambs is improved by naringin dietary supplementation at 0.15% rates but not meat quality. | 2012 | Animal | pmid:22558934 |
Choi MS et al. | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. | 2001 | Ann. Nutr. Metab. | pmid:11585976 |
Camargo CA et al. | Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcoma. | 2012 | Anticancer Res. | pmid:22213297 |
Liu T et al. | Aspergillus niger DLFCC-90 rhamnoside hydrolase, a new type of flavonoid glycoside hydrolase. | 2012 | Appl. Environ. Microbiol. | pmid:22544243 |
Beekwilder J et al. | Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus. | 2009 | Appl. Environ. Microbiol. | pmid:19346347 |
Soria F et al. | α-L-rhamnosidase of Aspergillus terreus immobilized on ferromagnetic supports. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21779843 |
Koseki T et al. | Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18633609 |
da Silva RR et al. | [Hypocholesterolemic effect of naringin and rutin flavonoids]. | 2001 | Arch Latinoam Nutr | pmid:11795241 |
Pu P et al. | Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. | 2012 | Arch. Biochem. Biophys. | pmid:22198281 |
Chen LL et al. | Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. | 2011 | Arch. Oral Biol. | pmid:21764032 |
Choi JS and Kang KW | Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. | 2008 | Arch. Pharm. Res. | pmid:19099234 |
Yeum CH and Choi JS | Effect of naringin pretreatment on bioavailability of verapamil in rabbits. | 2006 | Arch. Pharm. Res. | pmid:16491851 |