NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wong RW and Rabie AB | Effect of naringin collagen graft on bone formation. | 2006 | Biomaterials | pmid:16310246 |
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| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. | 2006 | Toxicology | pmid:17084010 |
| Wong RW and Rabie AB | Effect of naringin on bone cells. | 2006 | J. Orthop. Res. | pmid:16944474 |
| Zhang L et al. | Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. | 2006 | J. Pharm. Pharmacol. | pmid:16945185 |
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| Zhou DY et al. | Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. | 2006 | J Pharm Biomed Anal | pmid:16837161 |
| Kanno S et al. | Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. | 2006 | Life Sci. | pmid:16137700 |
| Lim SC and Choi JS | Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. | 2006 | Biopharm Drug Dispos | pmid:17009338 |
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| Rajadurai M and Prince PS | Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: an in vivo and in vitro study. | 2007 | Toxicology | pmid:17289242 |
| Wang W et al. | Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. | 2007 | J Chromatogr A | pmid:17383667 |
| Bailey DG et al. | Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. | 2007 | Clin. Pharmacol. Ther. | pmid:17301733 |
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| Go YH et al. | Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids. | 2007 | J. Microbiol. Biotechnol. | pmid:18062236 |
| Wei M et al. | Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model. | 2007 | Am. J. Chin. Med. | pmid:17708632 |
| Ding L et al. | Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17689302 |
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| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. | 2007 | Toxicology | pmid:17188415 |
| Mello LD et al. | Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)-naringin complex. | 2007 | J Pharm Biomed Anal | pmid:17881180 |
| Jagetia A et al. | Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival. | 2007 Mar-Apr | J Appl Toxicol | pmid:17177233 |
| Choi JS and Kang KW | Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. | 2008 | Arch. Pharm. Res. | pmid:19099234 |
| Uchiyama N et al. | HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines. | 2008 | J Pharm Biomed Anal | pmid:17532169 |
| Maehashi K et al. | Riboflavin-binding protein is a novel bitter inhibitor. | 2008 | Chem. Senses | pmid:17846099 |
| Punithavathi VR et al. | Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. | 2008 | J Appl Toxicol | pmid:18344197 |
| Kim DI et al. | Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. | 2008 | Carcinogenesis | pmid:18296682 |
| Wu JB et al. | Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. | 2008 | Eur. J. Pharmacol. | pmid:18495116 |
| Koseki T et al. | Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18633609 |
| Attia SM | Abatement by naringin of lomefloxacin-induced genomic instability in mice. | 2008 | Mutagenesis | pmid:18755759 |
| Tramice A et al. | Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. | 2008 | Biotechnol J | pmid:18098121 |
| Tsui VW et al. | The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. | 2008 | Phytother Res | pmid:18167053 |
| Lee EJ et al. | Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. | 2008 | Food Chem. Toxicol. | pmid:18951945 |
| Oliva J et al. | Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. | 2008 | Exp. Mol. Pathol. | pmid:18793633 |
| Vij G et al. | Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant. | 2009 | Fundam Clin Pharmacol | pmid:19469804 |
| Iqbal MF and Zhu WY | Bioactivation of flavonoid diglycosides by chicken cecal bacteria. | 2009 | FEMS Microbiol. Lett. | pmid:19473248 |
| Gaur V et al. | Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. | 2009 | Eur. J. Pharmacol. | pmid:19577560 |
| Itoh K et al. | Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice. | 2009 | J Nat Med | pmid:19603253 |
| Chen JC et al. | [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice]. | 2009 | Zhong Xi Yi Jie He Xue Bao | pmid:19583936 |
| Koca U et al. | Decreasing unpalatable flavonoid components in Citrus: the effect of transformation construct. | 2009 | Physiol Plant | pmid:19656329 |
| Laska M et al. | Gustatory responsiveness to six bitter tastants in three species of nonhuman primates. | 2009 | J. Chem. Ecol. | pmid:19399556 |
| Gong HL et al. | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components. | 2009 | World J. Gastroenterol. | pmid:20014465 |
| Luo R et al. | Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies. | 2009 | Yakugaku Zasshi | pmid:19952535 |
| Ding P et al. | [Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19873788 |
| Little TJ et al. | Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19535679 |
| Sansone F et al. | Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying. | 2009 | Eur J Pharm Biopharm | pmid:18996478 |
| Kanaze FI et al. | The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin. | 2009 | Biomed. Chromatogr. | pmid:18823075 |
| Rajadurai M and Prince PS | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. | 2009 | Phytother Res | pmid:18844325 |
| Zhang P et al. | Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. | 2009 | Eur. J. Pharmacol. | pmid:19326565 |
| Beekwilder J et al. | Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus. | 2009 | Appl. Environ. Microbiol. | pmid:19346347 |
| Shirasaka Y et al. | Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). | 2009 | Pharm. Res. | pmid:19002566 |
| Ali MM et al. | Modulation of anticancer drug-induced P-glycoprotein expression by naringin. | 2009 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:19323275 |
| Qin XM et al. | Discrimination of three medicinal materials from the Citrus genus by HPLC fingerprint coupled with two complementary software. | 2009 Jul-Aug | Phytochem Anal | pmid:19425114 |
| Pang WY et al. | Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. | 2010 | Br. J. Pharmacol. | pmid:20397301 |
| Belboukhari N et al. | Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens. | 2010 | Nat. Prod. Res. | pmid:20401799 |
| Zhou X et al. | Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. | 2010 | J. Orthop. Res. | pmid:19824055 |
| Caccamese S and Chillemi R | Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography. | 2010 | J Chromatogr A | pmid:19913235 |
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| Cariño-Cortés R et al. | Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes. | 2010 | Biol. Pharm. Bull. | pmid:20410608 |
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| Xiong Y et al. | [Naringin inhibits monocyte adhesion to high glucose-induced human umbilical vein endothelial cells]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20159712 |
| Hu QY et al. | [Traditional Chinese medicine Drynaria fortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175240 |
| Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. | 2010 | Pharm. Res. | pmid:20686826 |
| Kumar A et al. | Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. | 2010 | J Med Food | pmid:20673063 |
| Kumar A et al. | Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. | 2010 | Food Chem. Toxicol. | pmid:19941926 |
| Wang J et al. | [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20862961 |
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| Li C et al. | Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS. | 2010 May-Jun | J Chromatogr Sci | pmid:20515525 |
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| Jagetia GC and Reddy TK | Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. | 2011 | Chem. Biol. Interact. | pmid:21345335 |
| Kim SW et al. | Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22074828 |
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| Sharma AK et al. | Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. | 2011 | Br. J. Nutr. | pmid:21736771 |
| Li L et al. | Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. | 2011 | Phytomedicine | pmid:21741227 |
| Chen LL et al. | Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. | 2011 | Arch. Oral Biol. | pmid:21764032 |
| Liu M et al. | Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787720 |
| Ang ES et al. | Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. | 2011 | FEBS Lett. | pmid:21835177 |
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| Gopinath K et al. | Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. | 2011 | Neurochem. Int. | pmid:21945202 |
| ElÃades LA et al. | α-L-rhamnosidase and β-D-glucosidase activities in fungal strains isolated from alkaline soils and their potential in naringin hydrolysis. | 2011 | J. Basic Microbiol. | pmid:21952976 |
| Dai H et al. | A highly sensitive and selective sensing ECL platform for naringin based on β-Cyclodextrin functionalized carbon nanohorns. | 2011 | Chem. Commun. (Camb.) | pmid:21975830 |
| Leray V et al. | Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. | 2011 | Br. J. Nutr. | pmid:22005428 |
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| Liu Y et al. | Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. | 2011 | Int. Immunopharmacol. | pmid:21640201 |
| Bodas R et al. | Naringin and vitamin E influence the oxidative stability and lipid profile of plasma in lambs fed fish oil. | 2011 | Res. Vet. Sci. | pmid:20800247 |
| Yamakawa Y et al. | Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. | 2011 | Clin. Pharmacol. Ther. | pmid:21633340 |
| Catalán-Latorre A et al. | In situ study of the effect of naringin, talinolol and protein-energy undernutrition on intestinal absorption of saquinavir in rats. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21535410 |
| Golechha M et al. | Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. | 2011 | Biol. Pharm. Bull. | pmid:21372385 |
| Yow TT et al. | Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. | 2011 | Br. J. Pharmacol. | pmid:21391982 |
| Mangan RL et al. | Grapefruit as a host for the West Indian fruit fly (Diptera: Tephritidae). | 2011 | J. Econ. Entomol. | pmid:21404839 |
| Xu D and Cheng K | [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21473151 |