NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Zhang L et al. | Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. | 2006 | J. Pharm. Pharmacol. | pmid:16945185 |
Wong RW and Rabie AB | Effect of naringin on bone cells. | 2006 | J. Orthop. Res. | pmid:16944474 |
Chen L et al. | [Specific depletion of naringin from Si-Ni-San, a traditional Chinese prescription, by an immunoaffinity chromatography]. | 2006 | Se Pu | pmid:16929840 |
Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in Wistar rats. | 2006 | J. Biochem. Mol. Toxicol. | pmid:16906524 |
Zhou DY et al. | Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. | 2006 | J Pharm Biomed Anal | pmid:16837161 |
Ballard TL et al. | Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16620293 |
Clowers BH and Hill HH | Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498610 |
Yeum CH and Choi JS | Effect of naringin pretreatment on bioavailability of verapamil in rabbits. | 2006 | Arch. Pharm. Res. | pmid:16491851 |
Katsoura MH et al. | Use of ionic liquids as media for the biocatalytic preparation of flavonoid derivatives with antioxidant potency. | 2006 | J. Biotechnol. | pmid:16457903 |
Jung UJ et al. | Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16427799 |
Vanamala J et al. | Suppression of colon carcinogenesis by bioactive compounds in grapefruit. | 2006 | Carcinogenesis | pmid:16387741 |
Krakstad C et al. | CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. | 2006 | Cell Death Differ. | pmid:16311514 |
Wong RW and Rabie AB | Effect of naringin collagen graft on bone formation. | 2006 | Biomaterials | pmid:16310246 |
Choi JS and Han HK | Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. | 2005 | Int J Pharm | pmid:16226412 |
Tourniaire F et al. | Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells. | 2005 | Mol Nutr Food Res | pmid:16189799 |
Kanno S et al. | Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. | 2006 | Life Sci. | pmid:16137700 |
Kubo M et al. | [History and therapeutic evaluation of Citrus hassaku HORT. Tanaka]. | 2004 | Yakushigaku Zasshi | pmid:16025659 |
Desiderio C et al. | Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography. | 2005 | J Chromatogr A | pmid:16013605 |
Kim HJ and Choi JS | Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits. | 2005 | Biopharm Drug Dispos | pmid:16013069 |
Huang ZF et al. | [Study on quality control of effective fraction in qixue bingzhi decoction]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011278 |
Jagetia GC and Reddy TK | Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. | 2005 | Life Sci. | pmid:15936352 |
Mielczarek C | Acid-base properties of selected flavonoid glycosides. | 2005 | Eur J Pharm Sci | pmid:15911223 |
Muller GW et al. | Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1. | 1992 | J. Med. Chem. | pmid:1588556 |
Gorinstein S et al. | Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. | 2005 | J. Agric. Food Chem. | pmid:15826081 |
Choi JS and Shin SC | Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. | 2005 | Int J Pharm | pmid:15725561 |
Zhang J and Brodbelt JS | Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. | 2004 | Analyst | pmid:15565223 |
Jung UJ et al. | The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. | 2004 | J. Nutr. | pmid:15465737 |
Samari HR et al. | Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. | 2005 | Biochem. J. | pmid:15461583 |
Jeon SM et al. | Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. | 2004 | Clin Nutr | pmid:15380892 |
Yoo KM et al. | Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. | 2004 | J. Agric. Food Chem. | pmid:15366841 |
Kanaze FI et al. | A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. | 2004 | J Pharm Biomed Anal | pmid:15351063 |
Møller MT et al. | Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. | 2004 | Toxicol. Sci. | pmid:15342961 |
Jagetia GC et al. | Influence of naringin on ferric iron induced oxidative damage in vitro. | 2004 | Clin. Chim. Acta | pmid:15313158 |
Singh D et al. | Protective effect of naringin, a bioflavonoid on glycerol-induced acute renal failure in rat kidney. | 2004 | Toxicology | pmid:15297029 |
Singh D et al. | Protective effect of naringin, a bioflavonoid on ferric nitrilotriacetate-induced oxidative renal damage in rat kidney. | 2004 | Toxicology | pmid:15297014 |
Singh D and Chopra K | The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. | 2004 | Pharmacol. Res. | pmid:15177308 |
Kanno S et al. | Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. | 2004 | Life Sci. | pmid:15135655 |
Li X et al. | LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. | 2004 | J Pharm Biomed Anal | pmid:14738930 |
Kim HJ et al. | Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. | 2004 | Life Sci. | pmid:14738906 |
Jung UJ et al. | Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. | 2003 | Clin Nutr | pmid:14613759 |
Martearena MR et al. | Synthesis of alkyl-alpha-L-rhamnosides by water soluble alcohols enzymatic glycosylation. | 2003 | Bioresour. Technol. | pmid:14575952 |
Kanaze FI et al. | Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. | 2003 | J Pharm Biomed Anal | pmid:12972089 |
Caccamese S et al. | Chiral HPLC separation and CD spectra of the C-2 diastereomers of naringin in grapefruit during maturation. | 2003 | Chirality | pmid:12923803 |
Li J et al. | [A review of the study on Drynaria fortunei]. | 1999 | Zhong Yao Cai | pmid:12903628 |
Giannuzzo AN et al. | Supercritical fluid extraction of naringin from the peel of Citrus paradisi. | 2003 Jul-Aug | Phytochem Anal | pmid:12892417 |
Jagetia GC et al. | Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. | 2003 | Mutagenesis | pmid:12840107 |
Kanno S et al. | Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. | 2003 | J. Pharmacol. Sci. | pmid:12832847 |
Seo HJ et al. | Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. | 2003 | Life Sci. | pmid:12798418 |
Hermans K et al. | Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome. | 2003 | Am. J. Med. | pmid:12727589 |
Møller MT et al. | Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. | 2003 | Biochem. J. | pmid:12697024 |
Li XL et al. | [Determination of hesperidin and naringin in Fructus Aurantii Immaturus and Fructus Aurantii by reversed-phase high performance liquid chromatography]. | 2002 | Se Pu | pmid:12683015 |
Xiao M et al. | [Determination of naringin and synephrine in fructus aurantii from different habitats by HPLC]. | 2000 | Zhong Yao Cai | pmid:12575153 |
Hu Y et al. | [Pharmacognostical identification of one Rhizoma Drynariae habitually used species from Yunnan]. | 2000 | Zhong Yao Cai | pmid:12575083 |
Tsai TH | Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. | 2002 | J. Agric. Food Chem. | pmid:12405759 |
Soria F and Ellenrieder G | Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224626 |
Jagetia GC and Reddy TK | The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. | 2002 | Mutat. Res. | pmid:12160890 |
Larsen AK et al. | Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes. | 2002 | J. Biol. Chem. | pmid:12095991 |
Ohtani M et al. | [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine]. | 2002 | Yakugaku Zasshi | pmid:12040751 |
Scaroni E et al. | Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi. | 2002 | Lett. Appl. Microbiol. | pmid:12028430 |
Elinbaum S et al. | Production of Aspergillus terreus alpha-L-rhamnosidase by solid state fermentation. | 2002 | Lett. Appl. Microbiol. | pmid:11849496 |
Jeon SM et al. | Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. | 2002 | Clin. Chim. Acta | pmid:11814474 |
da Silva RR et al. | [Hypocholesterolemic effect of naringin and rutin flavonoids]. | 2001 | Arch Latinoam Nutr | pmid:11795241 |
Ramesh N et al. | Phytochemical and antimicrobial studies on Drynaria quercifolia. | 2001 | Fitoterapia | pmid:11731121 |
Jeon SM et al. | Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. | 2001 | Life Sci. | pmid:11720089 |
Choe SC et al. | Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. | 2001 | J. Cardiovasc. Pharmacol. | pmid:11707699 |
Wang Y and Li J | [Qualitative identification and quantitative determination of naringin in rhizoma Drynariae by TLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599350 |
Choi MS et al. | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. | 2001 | Ann. Nutr. Metab. | pmid:11585976 |
Alvarez-González I et al. | Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamily. | 2001 | Mutat. Res. | pmid:11506811 |
Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
Akiyama T et al. | Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129606 |
Bailey DG et al. | Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. | 2000 | Clin. Pharmacol. Ther. | pmid:11103749 |
Widmer W | Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. | 2000 Sep-Oct | J AOAC Int | pmid:11048857 |
Berven G et al. | Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. | 2001 Feb-Mar | Toxicon | pmid:10978754 |
Blankson H et al. | Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. | 2000 | Cell Death Differ. | pmid:10918448 |
Russo A et al. | Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. | 2000 | Cell Biol. Toxicol. | pmid:10917564 |
Cohen MF and Yamasaki H | Flavonoid-induced expression of a symbiosis-related gene in the cyanobacterium Nostoc punctiforme. | 2000 | J. Bacteriol. | pmid:10913102 |
Jung DM et al. | Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy. | 2000 | J. Agric. Food Chem. | pmid:10691648 |
Ishii K et al. | Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. | 2000 | J. Agric. Food Chem. | pmid:10637051 |
Zverlov VV et al. | The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. | 2000 | Mol. Microbiol. | pmid:10632887 |
Lee SJ et al. | Transglycosylation of naringin by Bacillus stearothermophilusMaltogenic amylase to give glycosylated naringin. | 1999 | J. Agric. Food Chem. | pmid:10552702 |
Shin YW et al. | Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. | 1999 | Int J Vitam Nutr Res | pmid:10526779 |
Seto E et al. | Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. | 1999 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10386788 |
Kawaguchi K et al. | Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. | 1999 | Eur. J. Pharmacol. | pmid:10193661 |