NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kawaguchi K et al. | Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. | 1999 | Eur. J. Pharmacol. | pmid:10193661 |
| Seto E et al. | Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. | 1999 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10386788 |
| Shin YW et al. | Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. | 1999 | Int J Vitam Nutr Res | pmid:10526779 |
| Lee SJ et al. | Transglycosylation of naringin by Bacillus stearothermophilusMaltogenic amylase to give glycosylated naringin. | 1999 | J. Agric. Food Chem. | pmid:10552702 |
| Zverlov VV et al. | The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. | 2000 | Mol. Microbiol. | pmid:10632887 |
| Ishii K et al. | Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. | 2000 | J. Agric. Food Chem. | pmid:10637051 |
| Jung DM et al. | Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy. | 2000 | J. Agric. Food Chem. | pmid:10691648 |
| Cohen MF and Yamasaki H | Flavonoid-induced expression of a symbiosis-related gene in the cyanobacterium Nostoc punctiforme. | 2000 | J. Bacteriol. | pmid:10913102 |
| Russo A et al. | Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. | 2000 | Cell Biol. Toxicol. | pmid:10917564 |
| Blankson H et al. | Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. | 2000 | Cell Death Differ. | pmid:10918448 |
| Berven G et al. | Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. | 2001 Feb-Mar | Toxicon | pmid:10978754 |
| Widmer W | Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. | 2000 Sep-Oct | J AOAC Int | pmid:11048857 |
| Bailey DG et al. | Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. | 2000 | Clin. Pharmacol. Ther. | pmid:11103749 |
| Akiyama T et al. | Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129606 |
| Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
| Alvarez-González I et al. | Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamily. | 2001 | Mutat. Res. | pmid:11506811 |
| Choi MS et al. | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. | 2001 | Ann. Nutr. Metab. | pmid:11585976 |
| Wang Y and Li J | [Qualitative identification and quantitative determination of naringin in rhizoma Drynariae by TLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599350 |
| Choe SC et al. | Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. | 2001 | J. Cardiovasc. Pharmacol. | pmid:11707699 |
| Jeon SM et al. | Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. | 2001 | Life Sci. | pmid:11720089 |