NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mello LD et al. | Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)-naringin complex. | 2007 | J Pharm Biomed Anal | pmid:17881180 |
Pereira RM et al. | Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. | 2007 | Molecules | pmid:17909491 |
Rajadurai M and Prince PS | Preventive effect of naringin on cardiac mitochondrial enzymes during isoproterenol-induced myocardial infarction in rats: a transmission electron microscopic study. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17994577 |
Go YH et al. | Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids. | 2007 | J. Microbiol. Biotechnol. | pmid:18062236 |
Tramice A et al. | Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. | 2008 | Biotechnol J | pmid:18098121 |
Tsui VW et al. | The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. | 2008 | Phytother Res | pmid:18167053 |
Kim DI et al. | Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. | 2008 | Carcinogenesis | pmid:18296682 |
Zhang LH et al. | [Optimal extraction of Dingxiang jiangqi granules]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309666 |
Punithavathi VR et al. | Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. | 2008 | J Appl Toxicol | pmid:18344197 |
Wu JB et al. | Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. | 2008 | Eur. J. Pharmacol. | pmid:18495116 |
Koseki T et al. | Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18633609 |
Attia SM | Abatement by naringin of lomefloxacin-induced genomic instability in mice. | 2008 | Mutagenesis | pmid:18755759 |
Oliva J et al. | Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. | 2008 | Exp. Mol. Pathol. | pmid:18793633 |
Kanaze FI et al. | The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin. | 2009 | Biomed. Chromatogr. | pmid:18823075 |
Rajadurai M and Prince PS | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. | 2009 | Phytother Res | pmid:18844325 |
Lee EJ et al. | Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. | 2008 | Food Chem. Toxicol. | pmid:18951945 |
Sansone F et al. | Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying. | 2009 | Eur J Pharm Biopharm | pmid:18996478 |
Shirasaka Y et al. | Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). | 2009 | Pharm. Res. | pmid:19002566 |
Choi JS and Kang KW | Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. | 2008 | Arch. Pharm. Res. | pmid:19099234 |
Ali MM et al. | Modulation of anticancer drug-induced P-glycoprotein expression by naringin. | 2009 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:19323275 |