NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pereira RM et al. | Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. | 2007 | Molecules | pmid:17909491 |
Rajadurai M and Prince PS | Preventive effect of naringin on cardiac mitochondrial enzymes during isoproterenol-induced myocardial infarction in rats: a transmission electron microscopic study. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17994577 |
Go YH et al. | Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids. | 2007 | J. Microbiol. Biotechnol. | pmid:18062236 |
Tramice A et al. | Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. | 2008 | Biotechnol J | pmid:18098121 |
Tsui VW et al. | The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. | 2008 | Phytother Res | pmid:18167053 |
Kim DI et al. | Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. | 2008 | Carcinogenesis | pmid:18296682 |
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Punithavathi VR et al. | Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. | 2008 | J Appl Toxicol | pmid:18344197 |
Wu JB et al. | Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. | 2008 | Eur. J. Pharmacol. | pmid:18495116 |
Koseki T et al. | Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18633609 |
Attia SM | Abatement by naringin of lomefloxacin-induced genomic instability in mice. | 2008 | Mutagenesis | pmid:18755759 |
Oliva J et al. | Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. | 2008 | Exp. Mol. Pathol. | pmid:18793633 |
Kanaze FI et al. | The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin. | 2009 | Biomed. Chromatogr. | pmid:18823075 |
Rajadurai M and Prince PS | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. | 2009 | Phytother Res | pmid:18844325 |
Lee EJ et al. | Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. | 2008 | Food Chem. Toxicol. | pmid:18951945 |
Sansone F et al. | Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying. | 2009 | Eur J Pharm Biopharm | pmid:18996478 |
Shirasaka Y et al. | Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). | 2009 | Pharm. Res. | pmid:19002566 |
Choi JS and Kang KW | Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. | 2008 | Arch. Pharm. Res. | pmid:19099234 |
Ali MM et al. | Modulation of anticancer drug-induced P-glycoprotein expression by naringin. | 2009 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:19323275 |
Zhang P et al. | Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. | 2009 | Eur. J. Pharmacol. | pmid:19326565 |
Beekwilder J et al. | Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus. | 2009 | Appl. Environ. Microbiol. | pmid:19346347 |
Laska M et al. | Gustatory responsiveness to six bitter tastants in three species of nonhuman primates. | 2009 | J. Chem. Ecol. | pmid:19399556 |
Qin XM et al. | Discrimination of three medicinal materials from the Citrus genus by HPLC fingerprint coupled with two complementary software. | 2009 Jul-Aug | Phytochem Anal | pmid:19425114 |
Vij G et al. | Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant. | 2009 | Fundam Clin Pharmacol | pmid:19469804 |
Iqbal MF and Zhu WY | Bioactivation of flavonoid diglycosides by chicken cecal bacteria. | 2009 | FEMS Microbiol. Lett. | pmid:19473248 |
Little TJ et al. | Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19535679 |
Gaur V et al. | Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. | 2009 | Eur. J. Pharmacol. | pmid:19577560 |
Chen JC et al. | [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice]. | 2009 | Zhong Xi Yi Jie He Xue Bao | pmid:19583936 |
Itoh K et al. | Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice. | 2009 | J Nat Med | pmid:19603253 |
Koca U et al. | Decreasing unpalatable flavonoid components in Citrus: the effect of transformation construct. | 2009 | Physiol Plant | pmid:19656329 |
Kumar P and Kumar A | Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide. | 2010 | Behav. Brain Res. | pmid:19716383 |
Shirasaka Y et al. | Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19779132 |
Zhou X et al. | Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. | 2010 | J. Orthop. Res. | pmid:19824055 |
Ding P et al. | [Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19873788 |
Caccamese S and Chillemi R | Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography. | 2010 | J Chromatogr A | pmid:19913235 |
Kumar A et al. | Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. | 2010 | Food Chem. Toxicol. | pmid:19941926 |
Luo R et al. | Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies. | 2009 | Yakugaku Zasshi | pmid:19952535 |
Gong HL et al. | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components. | 2009 | World J. Gastroenterol. | pmid:20014465 |
Xiong Y et al. | [Naringin inhibits monocyte adhesion to high glucose-induced human umbilical vein endothelial cells]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20159712 |
Hu QY et al. | [Traditional Chinese medicine Drynaria fortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175240 |
Pang WY et al. | Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. | 2010 | Br. J. Pharmacol. | pmid:20397301 |
Belboukhari N et al. | Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens. | 2010 | Nat. Prod. Res. | pmid:20401799 |
Cariño-Cortés R et al. | Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes. | 2010 | Biol. Pharm. Bull. | pmid:20410608 |
Aggarwal A et al. | Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. | 2010 | Life Sci. | pmid:20433854 |
Li C et al. | Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS. | 2010 May-Jun | J Chromatogr Sci | pmid:20515525 |
Gao S et al. | Antitussive effect of naringin on experimentally induced cough in Guinea pigs. | 2011 | Planta Med. | pmid:20645246 |
Demonty I et al. | The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. | 2010 | J. Nutr. | pmid:20660284 |
Kumar A et al. | Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. | 2010 | J Med Food | pmid:20673063 |
Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. | 2010 | Pharm. Res. | pmid:20686826 |
Bodas R et al. | Naringin and vitamin E influence the oxidative stability and lipid profile of plasma in lambs fed fish oil. | 2011 | Res. Vet. Sci. | pmid:20800247 |
Wang J et al. | [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20862961 |
Puri M et al. | Molecular characterization and enzymatic hydrolysis of naringin extracted from kinnow peel waste. | 2011 | Int. J. Biol. Macromol. | pmid:20920523 |
Pari L and Amudha K | Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. | 2011 | Eur. J. Pharmacol. | pmid:20950607 |
KEENAN GL | The occurrence of crystalline naringin on grapefruit rind. | 1946 | Science | pmid:20995510 |
Jain M and Parmar HS | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. | 2011 | Inflamm. Res. | pmid:21181230 |
Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. | 2011 | Drug Metab. Pharmacokinet. | pmid:21206133 |
Rojas NL et al. | Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21221705 |
Santos ML et al. | Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin. | 2011 | Molecules | pmid:21245808 |
Walker AL et al. | Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. | 2011 | Exp. Hematol. | pmid:21256917 |
Jagetia GC and Reddy TK | Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. | 2011 | Chem. Biol. Interact. | pmid:21345335 |
Golechha M et al. | Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. | 2011 | Biol. Pharm. Bull. | pmid:21372385 |
Yow TT et al. | Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. | 2011 | Br. J. Pharmacol. | pmid:21391982 |
Mangan RL et al. | Grapefruit as a host for the West Indian fruit fly (Diptera: Tephritidae). | 2011 | J. Econ. Entomol. | pmid:21404839 |
Prota L et al. | Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells. | 2011 | Int J Pharm | pmid:21459138 |
Xu D and Cheng K | [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21473151 |
Kawaguchi K et al. | Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin. | 2011 | Immunopharmacol Immunotoxicol | pmid:21480758 |
Harapu CD et al. | [Flavonoids--bioactive compounds in fruits juice]. | 2010 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:21500482 |
Si-Si W et al. | Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin. | 2011 | Pharm Biol | pmid:21500970 |
Shirasaka Y et al. | Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. | 2011 | J Pharm Sci | pmid:21520088 |
Catalán-Latorre A et al. | In situ study of the effect of naringin, talinolol and protein-energy undernutrition on intestinal absorption of saquinavir in rats. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21535410 |
Stohs SJ et al. | Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. | 2011 | Int J Med Sci | pmid:21537493 |
Amudha K and Pari L | Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. | 2011 | Chem. Biol. Interact. | pmid:21600195 |
Yamakawa Y et al. | Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. | 2011 | Clin. Pharmacol. Ther. | pmid:21633340 |
Yilmaz D et al. | Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. | 2012 | Toxicol Ind Health | pmid:21636685 |
Liu Y et al. | Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. | 2011 | Int. Immunopharmacol. | pmid:21640201 |
Chanet A et al. | Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. | 2012 | J. Nutr. Biochem. | pmid:21684135 |
Sharma AK et al. | Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. | 2011 | Br. J. Nutr. | pmid:21736771 |
Li L et al. | Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. | 2011 | Phytomedicine | pmid:21741227 |
Chen LL et al. | Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. | 2011 | Arch. Oral Biol. | pmid:21764032 |
Soria F et al. | α-L-rhamnosidase of Aspergillus terreus immobilized on ferromagnetic supports. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21779843 |
Liu M et al. | Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787720 |
Ang ES et al. | Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. | 2011 | FEBS Lett. | pmid:21835177 |
A Bakheet S and M Attia S | Evaluation of chromosomal instability in diabetic rats treated with naringin. | 2011 | Oxid Med Cell Longev | pmid:21941606 |
Gopinath K et al. | Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. | 2011 | Neurochem. Int. | pmid:21945202 |
ElÃades LA et al. | α-L-rhamnosidase and β-D-glucosidase activities in fungal strains isolated from alkaline soils and their potential in naringin hydrolysis. | 2011 | J. Basic Microbiol. | pmid:21952976 |
Xulu S and Oroma Owira PM | Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes. | 2012 | J. Cardiovasc. Pharmacol. | pmid:21964158 |
Dai H et al. | A highly sensitive and selective sensing ECL platform for naringin based on β-Cyclodextrin functionalized carbon nanohorns. | 2011 | Chem. Commun. (Camb.) | pmid:21975830 |
Yu HY et al. | Anti-platelet effects of yuzu extract and its component. | 2011 | Food Chem. Toxicol. | pmid:22005257 |
Leray V et al. | Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. | 2011 | Br. J. Nutr. | pmid:22005428 |
Kim SW et al. | Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22074828 |
Viswanatha GL et al. | Amelioration of immobilization stress-induced biochemical and behavioral alterations and mitochondrial dysfunction by naringin in mice: possible mechanism of nitric oxide modulation. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088593 |
Ni H et al. | Characterization and preparation of Aspergillus niger naringinase for debittering citrus juice. | 2012 | J. Food Sci. | pmid:22122507 |
Rebello S et al. | Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects. | 2012 | Eur. J. Clin. Pharmacol. | pmid:22124880 |
Luo Z et al. | Effects of pH on the ability of flavonoids to act as Pickering emulsion stabilizers. | 2012 | Colloids Surf B Biointerfaces | pmid:22197223 |
Pu P et al. | Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. | 2012 | Arch. Biochem. Biophys. | pmid:22198281 |
Camargo CA et al. | Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcoma. | 2012 | Anticancer Res. | pmid:22213297 |
Poulaert M et al. | Grapefruit juices impair the bioaccessibility of β-carotene from orange-fleshed sweet potato but not its intestinal uptake by Caco-2 cells. | 2012 | J. Agric. Food Chem. | pmid:22221263 |
Ikemura M et al. | Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats. | 2012 | Phytother Res | pmid:22228501 |
Zou W et al. | Tissue distribution study of naringin in rats by liquid chromatography-tandem mass spectrometry. | 2012 | Arzneimittelforschung | pmid:22270844 |