| MeSH term | MeSH ID | Detail |
|---|---|---|
| Endophthalmitis | D009877 | 12 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tsui VW et al. | The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. | 2008 | Phytother Res | pmid:18167053 |
| Rajadurai M and Prince PS | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. | 2009 | Phytother Res | pmid:18844325 |
| Li L et al. | Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. | 2011 | Phytomedicine | pmid:21741227 |
| Qin XM et al. | Discrimination of three medicinal materials from the Citrus genus by HPLC fingerprint coupled with two complementary software. | 2009 Jul-Aug | Phytochem Anal | pmid:19425114 |
| Giannuzzo AN et al. | Supercritical fluid extraction of naringin from the peel of Citrus paradisi. | 2003 Jul-Aug | Phytochem Anal | pmid:12892417 |
| Koca U et al. | Decreasing unpalatable flavonoid components in Citrus: the effect of transformation construct. | 2009 | Physiol Plant | pmid:19656329 |
| Huang W et al. | Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus aurantii-type formulae. | 2012 | Pharmazie | pmid:22888512 |
| Jang Y et al. | Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats. | 2013 | Pharmacology | pmid:24080610 |
| Singh D and Chopra K | The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. | 2004 | Pharmacol. Res. | pmid:15177308 |
| Wang D et al. | Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease. | 2012 | Pharmacol. Biochem. Behav. | pmid:22741174 |
| Chandramohan Y and Parameswari CS | Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: involvement of hemeoxygenase-1. | 2013 | Pharmacol Rep | pmid:24399730 |
| Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. | 2010 | Pharm. Res. | pmid:20686826 |
| Shirasaka Y et al. | Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). | 2009 | Pharm. Res. | pmid:19002566 |
| Si-Si W et al. | Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin. | 2011 | Pharm Biol | pmid:21500970 |
| A Bakheet S and M Attia S | Evaluation of chromosomal instability in diabetic rats treated with naringin. | 2011 | Oxid Med Cell Longev | pmid:21941606 |
| Alam MA et al. | Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. | 2013 | Nutrients | pmid:23446977 |
| Gopinath K and Sudhandiran G | Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. | 2012 | Neuroscience | pmid:22871521 |
| Martini LH et al. | Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. | 2007 | Neurochem. Res. | pmid:17577666 |
| Maratha SR and Mahadevan N | Memory enhancing activity of naringin in unstressed and stressed mice: possible cholinergic and nitriergic modulation. | 2012 | Neurochem. Res. | pmid:22821418 |
| Rong W et al. | Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. | 2012 | Neurochem. Res. | pmid:22453521 |
| Gopinath K et al. | Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. | 2011 | Neurochem. Int. | pmid:21945202 |
| Belboukhari N et al. | Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens. | 2010 | Nat. Prod. Res. | pmid:20401799 |
| Xiong Y et al. | [Naringin inhibits monocyte adhesion to high glucose-induced human umbilical vein endothelial cells]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20159712 |
| Alvarez-González I et al. | Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamily. | 2001 | Mutat. Res. | pmid:11506811 |
| Jagetia GC and Reddy TK | The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. | 2002 | Mutat. Res. | pmid:12160890 |
| Attia SM | Abatement by naringin of lomefloxacin-induced genomic instability in mice. | 2008 | Mutagenesis | pmid:18755759 |
| Jagetia GC et al. | Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. | 2003 | Mutagenesis | pmid:12840107 |
| Pereira RM et al. | Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. | 2007 | Molecules | pmid:17909491 |
| Santos ML et al. | Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin. | 2011 | Molecules | pmid:21245808 |
| Kwatra D et al. | Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism. | 2012 | Mol. Pharm. | pmid:22676443 |
| Zverlov VV et al. | The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. | 2000 | Mol. Microbiol. | pmid:10632887 |
| Tourniaire F et al. | Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells. | 2005 | Mol Nutr Food Res | pmid:16189799 |
| Liu Y et al. | Naringin inhibits chemokine production in an LPS-induced RAW 264.7 macrophage cell line. | 2012 | Mol Med Rep | pmid:22965302 |
| Aggarwal A et al. | Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. | 2010 | Life Sci. | pmid:20433854 |
| Jagetia GC and Reddy TK | Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. | 2005 | Life Sci. | pmid:15936352 |
| Kanno S et al. | Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. | 2006 | Life Sci. | pmid:16137700 |
| Jeon SM et al. | Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. | 2001 | Life Sci. | pmid:11720089 |
| Seo HJ et al. | Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. | 2003 | Life Sci. | pmid:12798418 |
| Kanno S et al. | Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. | 2004 | Life Sci. | pmid:15135655 |
| Kim HJ et al. | Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. | 2004 | Life Sci. | pmid:14738906 |
| Elinbaum S et al. | Production of Aspergillus terreus alpha-L-rhamnosidase by solid state fermentation. | 2002 | Lett. Appl. Microbiol. | pmid:11849496 |
| Scaroni E et al. | Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi. | 2002 | Lett. Appl. Microbiol. | pmid:12028430 |
| Johnston A and Holt DW | Effect of grapefruit juice on blood cyclosporin concentration. | 1995 | Lancet | pmid:7603196 |
| Kanno S et al. | Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. | 2003 | J. Pharmacol. Sci. | pmid:12832847 |
| Zhao J et al. | Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis. | 2013 | J. Pharmacol. Sci. | pmid:23739595 |
| Shirasaka Y et al. | Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19779132 |
| Zhang L et al. | Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. | 2006 | J. Pharm. Pharmacol. | pmid:16945185 |
| Lassoued MA et al. | Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs. | 2012 | J. Pharm. Pharmacol. | pmid:22420660 |
| Zhou X et al. | Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. | 2010 | J. Orthop. Res. | pmid:19824055 |
| Wong RW and Rabie AB | Effect of naringin on bone cells. | 2006 | J. Orthop. Res. | pmid:16944474 |