NSC5548

NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.

Cross Reference

Introduction

To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with NSC5548?

NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with NSC5548

MeSH term MeSH ID Detail
Endophthalmitis D009877 12 associated lipids
Precancerous Conditions D011230 48 associated lipids
Reperfusion Injury D015427 65 associated lipids
Weight Gain D015430 101 associated lipids
Uveitis, Posterior D015866 5 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Chromosomal Instability D043171 5 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Per page 10 20 50 | Total 23

PubChem Associated disorders and diseases

What pathways are associated with NSC5548

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with NSC5548?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with NSC5548?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with NSC5548?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with NSC5548?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with NSC5548?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with NSC5548

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Per page 10 20 50 100 | Total 283
Authors Title Published Journal PubMed Link
Zhang L et al. Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. 2006 J. Pharm. Pharmacol. pmid:16945185
Wong RW and Rabie AB Effect of naringin on bone cells. 2006 J. Orthop. Res. pmid:16944474
Chen L et al. [Specific depletion of naringin from Si-Ni-San, a traditional Chinese prescription, by an immunoaffinity chromatography]. 2006 Se Pu pmid:16929840
Rajadurai M and Stanely Mainzen Prince P Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in Wistar rats. 2006 J. Biochem. Mol. Toxicol. pmid:16906524
Zhou DY et al. Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. 2006 J Pharm Biomed Anal pmid:16837161
Ballard TL et al. Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16620293
Clowers BH and Hill HH Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. 2006 J Mass Spectrom pmid:16498610
Yeum CH and Choi JS Effect of naringin pretreatment on bioavailability of verapamil in rabbits. 2006 Arch. Pharm. Res. pmid:16491851
Katsoura MH et al. Use of ionic liquids as media for the biocatalytic preparation of flavonoid derivatives with antioxidant potency. 2006 J. Biotechnol. pmid:16457903
Jung UJ et al. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. 2006 Int. J. Biochem. Cell Biol. pmid:16427799
Vanamala J et al. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. 2006 Carcinogenesis pmid:16387741
Krakstad C et al. CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. 2006 Cell Death Differ. pmid:16311514
Wong RW and Rabie AB Effect of naringin collagen graft on bone formation. 2006 Biomaterials pmid:16310246
Choi JS and Han HK Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. 2005 Int J Pharm pmid:16226412
Tourniaire F et al. Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells. 2005 Mol Nutr Food Res pmid:16189799
Kanno S et al. Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. 2006 Life Sci. pmid:16137700
Kubo M et al. [History and therapeutic evaluation of Citrus hassaku HORT. Tanaka]. 2004 Yakushigaku Zasshi pmid:16025659
Desiderio C et al. Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography. 2005 J Chromatogr A pmid:16013605
Kim HJ and Choi JS Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits. 2005 Biopharm Drug Dispos pmid:16013069
Huang ZF et al. [Study on quality control of effective fraction in qixue bingzhi decoction]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011278
Jagetia GC and Reddy TK Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. 2005 Life Sci. pmid:15936352
Mielczarek C Acid-base properties of selected flavonoid glycosides. 2005 Eur J Pharm Sci pmid:15911223
Muller GW et al. Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1. 1992 J. Med. Chem. pmid:1588556
Gorinstein S et al. Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. 2005 J. Agric. Food Chem. pmid:15826081
Choi JS and Shin SC Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. 2005 Int J Pharm pmid:15725561
Zhang J and Brodbelt JS Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. 2004 Analyst pmid:15565223
Jung UJ et al. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. 2004 J. Nutr. pmid:15465737
Samari HR et al. Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. 2005 Biochem. J. pmid:15461583
Jeon SM et al. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. 2004 Clin Nutr pmid:15380892
Yoo KM et al. Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. 2004 J. Agric. Food Chem. pmid:15366841
Kanaze FI et al. A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. 2004 J Pharm Biomed Anal pmid:15351063
Møller MT et al. Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. 2004 Toxicol. Sci. pmid:15342961
Jagetia GC et al. Influence of naringin on ferric iron induced oxidative damage in vitro. 2004 Clin. Chim. Acta pmid:15313158
Singh D et al. Protective effect of naringin, a bioflavonoid on glycerol-induced acute renal failure in rat kidney. 2004 Toxicology pmid:15297029
Singh D et al. Protective effect of naringin, a bioflavonoid on ferric nitrilotriacetate-induced oxidative renal damage in rat kidney. 2004 Toxicology pmid:15297014
Singh D and Chopra K The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. 2004 Pharmacol. Res. pmid:15177308
Kanno S et al. Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. 2004 Life Sci. pmid:15135655
Li X et al. LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. 2004 J Pharm Biomed Anal pmid:14738930
Kim HJ et al. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. 2004 Life Sci. pmid:14738906
Jung UJ et al. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. 2003 Clin Nutr pmid:14613759
Martearena MR et al. Synthesis of alkyl-alpha-L-rhamnosides by water soluble alcohols enzymatic glycosylation. 2003 Bioresour. Technol. pmid:14575952
Kanaze FI et al. Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. 2003 J Pharm Biomed Anal pmid:12972089
Caccamese S et al. Chiral HPLC separation and CD spectra of the C-2 diastereomers of naringin in grapefruit during maturation. 2003 Chirality pmid:12923803
Li J et al. [A review of the study on Drynaria fortunei]. 1999 Zhong Yao Cai pmid:12903628
Giannuzzo AN et al. Supercritical fluid extraction of naringin from the peel of Citrus paradisi. 2003 Jul-Aug Phytochem Anal pmid:12892417
Jagetia GC et al. Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. 2003 Mutagenesis pmid:12840107
Kanno S et al. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. 2003 J. Pharmacol. Sci. pmid:12832847
Seo HJ et al. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. 2003 Life Sci. pmid:12798418
Hermans K et al. Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome. 2003 Am. J. Med. pmid:12727589
Møller MT et al. Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. 2003 Biochem. J. pmid:12697024
Li XL et al. [Determination of hesperidin and naringin in Fructus Aurantii Immaturus and Fructus Aurantii by reversed-phase high performance liquid chromatography]. 2002 Se Pu pmid:12683015
Xiao M et al. [Determination of naringin and synephrine in fructus aurantii from different habitats by HPLC]. 2000 Zhong Yao Cai pmid:12575153
Hu Y et al. [Pharmacognostical identification of one Rhizoma Drynariae habitually used species from Yunnan]. 2000 Zhong Yao Cai pmid:12575083
Tsai TH Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. 2002 J. Agric. Food Chem. pmid:12405759
Soria F and Ellenrieder G Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. 2002 Biosci. Biotechnol. Biochem. pmid:12224626
Jagetia GC and Reddy TK The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. 2002 Mutat. Res. pmid:12160890
Larsen AK et al. Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes. 2002 J. Biol. Chem. pmid:12095991
Ohtani M et al. [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine]. 2002 Yakugaku Zasshi pmid:12040751
Scaroni E et al. Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi. 2002 Lett. Appl. Microbiol. pmid:12028430
Elinbaum S et al. Production of Aspergillus terreus alpha-L-rhamnosidase by solid state fermentation. 2002 Lett. Appl. Microbiol. pmid:11849496
Jeon SM et al. Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. 2002 Clin. Chim. Acta pmid:11814474
da Silva RR et al. [Hypocholesterolemic effect of naringin and rutin flavonoids]. 2001 Arch Latinoam Nutr pmid:11795241
Ramesh N et al. Phytochemical and antimicrobial studies on Drynaria quercifolia. 2001 Fitoterapia pmid:11731121
Jeon SM et al. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. 2001 Life Sci. pmid:11720089
Choe SC et al. Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. 2001 J. Cardiovasc. Pharmacol. pmid:11707699
Wang Y and Li J [Qualitative identification and quantitative determination of naringin in rhizoma Drynariae by TLC]. 1998 Zhongguo Zhong Yao Za Zhi pmid:11599350
Choi MS et al. Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. 2001 Ann. Nutr. Metab. pmid:11585976
Alvarez-González I et al. Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamily. 2001 Mutat. Res. pmid:11506811
Drewnowski A et al. Genetic taste markers and food preferences. 2001 Drug Metab. Dispos. pmid:11259346
Akiyama T et al. Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. 2000 Biosci. Biotechnol. Biochem. pmid:11129606
Bailey DG et al. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. 2000 Clin. Pharmacol. Ther. pmid:11103749
Widmer W Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. 2000 Sep-Oct J AOAC Int pmid:11048857
Berven G et al. Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. 2001 Feb-Mar Toxicon pmid:10978754
Blankson H et al. Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. 2000 Cell Death Differ. pmid:10918448
Russo A et al. Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. 2000 Cell Biol. Toxicol. pmid:10917564
Cohen MF and Yamasaki H Flavonoid-induced expression of a symbiosis-related gene in the cyanobacterium Nostoc punctiforme. 2000 J. Bacteriol. pmid:10913102
Jung DM et al. Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy. 2000 J. Agric. Food Chem. pmid:10691648
Ishii K et al. Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. 2000 J. Agric. Food Chem. pmid:10637051
Zverlov VV et al. The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. 2000 Mol. Microbiol. pmid:10632887
Lee SJ et al. Transglycosylation of naringin by Bacillus stearothermophilusMaltogenic amylase to give glycosylated naringin. 1999 J. Agric. Food Chem. pmid:10552702
Shin YW et al. Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. 1999 Int J Vitam Nutr Res pmid:10526779
Seto E et al. Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. 1999 Cell. Mol. Biol. (Noisy-le-grand) pmid:10386788
Kawaguchi K et al. Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. 1999 Eur. J. Pharmacol. pmid:10193661