NSC5548

NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.

Cross Reference

Introduction

To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with NSC5548?

NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with NSC5548

MeSH term MeSH ID Detail
Cough D003371 19 associated lipids
Cachexia D002100 21 associated lipids
Endophthalmitis D009877 12 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Atherosclerosis D050197 85 associated lipids
Acute Lung Injury D055371 33 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Neuralgia D009437 28 associated lipids
Per page 10 20 50 | Total 23

PubChem Associated disorders and diseases

What pathways are associated with NSC5548

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with NSC5548?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with NSC5548?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with NSC5548?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with NSC5548?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with NSC5548?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with NSC5548

Download all related citations
Per page 10 20 50 100 | Total 283
Authors Title Published Journal PubMed Link
Lambev I et al. Flavonoids with antioxidant action (naringin and rutin) and the release of mastocytic and nonmastocytic histamine. 1980 Acta Physiol Pharmacol Bulg pmid:6159775
Kempler GM Production of flavor compounds by microorganisms. 1983 Adv. Appl. Microbiol. pmid:6650264
Wei M et al. Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model. 2007 Am. J. Chin. Med. pmid:17708632
Drewnowski A et al. Taste responses to naringin, a flavonoid, and the acceptance of grapefruit juice are related to genetic sensitivity to 6-n-propylthiouracil. 1997 Am. J. Clin. Nutr. pmid:9250119
Hermans K et al. Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome. 2003 Am. J. Med. pmid:12727589
Little TJ et al. Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. 2009 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:19535679
Arnao MB et al. An enzymatic colorimetric method for measuring naringin using 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS) in the presence of peroxidase. 1990 Anal. Biochem. pmid:2339789
Zhang J and Brodbelt JS Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. 2004 Analyst pmid:15565223
Bodas R et al. The liver antioxidant status of fattening lambs is improved by naringin dietary supplementation at 0.15% rates but not meat quality. 2012 Animal pmid:22558934
Choi MS et al. Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. 2001 Ann. Nutr. Metab. pmid:11585976
Camargo CA et al. Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcoma. 2012 Anticancer Res. pmid:22213297
Liu T et al. Aspergillus niger DLFCC-90 rhamnoside hydrolase, a new type of flavonoid glycoside hydrolase. 2012 Appl. Environ. Microbiol. pmid:22544243
Beekwilder J et al. Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus. 2009 Appl. Environ. Microbiol. pmid:19346347
Soria F et al. α-L-rhamnosidase of Aspergillus terreus immobilized on ferromagnetic supports. 2012 Appl. Microbiol. Biotechnol. pmid:21779843
Koseki T et al. Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene. 2008 Appl. Microbiol. Biotechnol. pmid:18633609
da Silva RR et al. [Hypocholesterolemic effect of naringin and rutin flavonoids]. 2001 Arch Latinoam Nutr pmid:11795241
Pu P et al. Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet. 2012 Arch. Biochem. Biophys. pmid:22198281
Chen LL et al. Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. 2011 Arch. Oral Biol. pmid:21764032
Choi JS and Kang KW Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. 2008 Arch. Pharm. Res. pmid:19099234
Yeum CH and Choi JS Effect of naringin pretreatment on bioavailability of verapamil in rabbits. 2006 Arch. Pharm. Res. pmid:16491851
Zou W et al. Tissue distribution study of naringin in rats by liquid chromatography-tandem mass spectrometry. 2012 Arzneimittelforschung pmid:22270844
Catalán-Latorre A et al. In situ study of the effect of naringin, talinolol and protein-energy undernutrition on intestinal absorption of saquinavir in rats. 2011 Basic Clin. Pharmacol. Toxicol. pmid:21535410
Chen J et al. Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells. 2014 Basic Clin. Pharmacol. Toxicol. pmid:24118820
Kumar P and Kumar A Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide. 2010 Behav. Brain Res. pmid:19716383
Kim SW et al. Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. 2011 Biochem. Biophys. Res. Commun. pmid:22074828
Samari HR et al. Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. 2005 Biochem. J. pmid:15461583
Møller MT et al. Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. 2003 Biochem. J. pmid:12697024
Cariño-Cortés R et al. Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes. 2010 Biol. Pharm. Bull. pmid:20410608
Golechha M et al. Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. 2011 Biol. Pharm. Bull. pmid:21372385
Wong RW and Rabie AB Effect of naringin collagen graft on bone formation. 2006 Biomaterials pmid:16310246
Kanaze FI et al. The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin. 2009 Biomed. Chromatogr. pmid:18823075
Kim HJ and Choi JS Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits. 2005 Biopharm Drug Dispos pmid:16013069
Lim SC and Choi JS Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. 2006 Biopharm Drug Dispos pmid:17009338
Liu M et al. Metabolism and excretion studies of oral administered naringin, a putative antitussive, in rats and dogs. 2012 Biopharm Drug Dispos pmid:22374702
Liu Q et al. Cell surface engineering of α-l-rhamnosidase for naringin hydrolysis. 2012 Bioresour. Technol. pmid:22940311
Martearena MR et al. Synthesis of alkyl-alpha-L-rhamnosides by water soluble alcohols enzymatic glycosylation. 2003 Bioresour. Technol. pmid:14575952
Nunes MA et al. Microtiter plates versus stirred mini-bioreactors in biocatalysis: a scalable approach. 2013 Bioresour. Technol. pmid:23563437
Kometani T et al. Synthesis of neohesperidin glycosides and naringin glycosides by cyclodextrin glucanotransferase from an alkalophilic Bacillus species. 1996 Biosci. Biotechnol. Biochem. pmid:8829532
Kawaguchi K et al. Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas. 1997 Biosci. Biotechnol. Biochem. pmid:9028038
Akiyama T et al. Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. 2000 Biosci. Biotechnol. Biochem. pmid:11129606
Soria F and Ellenrieder G Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. 2002 Biosci. Biotechnol. Biochem. pmid:12224626
Ichinose H et al. Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis. 2013 Biosci. Biotechnol. Biochem. pmid:23291751
Tramice A et al. Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. 2008 Biotechnol J pmid:18098121
Sharma AK et al. Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. 2011 Br. J. Nutr. pmid:21736771
Leray V et al. Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. 2011 Br. J. Nutr. pmid:22005428
Pang WY et al. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. 2010 Br. J. Pharmacol. pmid:20397301
Yow TT et al. Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. 2011 Br. J. Pharmacol. pmid:21391982
Kim DI et al. Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. 2008 Carcinogenesis pmid:18296682
Vanamala J et al. Suppression of colon carcinogenesis by bioactive compounds in grapefruit. 2006 Carcinogenesis pmid:16387741
Russo A et al. Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. 2000 Cell Biol. Toxicol. pmid:10917564
Krakstad C et al. CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. 2006 Cell Death Differ. pmid:16311514
Blankson H et al. Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. 2000 Cell Death Differ. pmid:10918448
Ahmad SF et al. Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines. 2014 Cell. Immunol. pmid:24487035
Seto E et al. Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. 1999 Cell. Mol. Biol. (Noisy-le-grand) pmid:10386788
Shaik N et al. Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. 2012 Cell. Physiol. Biochem. pmid:22854627
Jagetia GC and Reddy TK Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. 2011 Chem. Biol. Interact. pmid:21345335
Ozyürek M et al. Novel oxime based flavanone, naringin-oxime: synthesis, characterization and screening for antioxidant activity. 2014 Chem. Biol. Interact. pmid:24508591
Amudha K and Pari L Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. 2011 Chem. Biol. Interact. pmid:21600195
Dai H et al. A highly sensitive and selective sensing ECL platform for naringin based on β-Cyclodextrin functionalized carbon nanohorns. 2011 Chem. Commun. (Camb.) pmid:21975830
Maehashi K et al. Riboflavin-binding protein is a novel bitter inhibitor. 2008 Chem. Senses pmid:17846099
Gong HL et al. Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats. 2012 Chin J Integr Med pmid:22936325
Wang JN et al. Population pharmacokinetics of naringin in total flavonoids of Drynaria fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis. 2012 Chin J Integr Med pmid:23239001
Caccamese S et al. Chiral HPLC separation and CD spectra of the C-2 diastereomers of naringin in grapefruit during maturation. 2003 Chirality pmid:12923803
Jung UJ et al. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. 2003 Clin Nutr pmid:14613759
Jeon SM et al. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. 2004 Clin Nutr pmid:15380892
Bailey DG et al. Grapefruit juice and drugs. How significant is the interaction? 1994 Clin Pharmacokinet pmid:8162660
Jeon SM et al. Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. 2002 Clin. Chim. Acta pmid:11814474
Jagetia GC et al. Influence of naringin on ferric iron induced oxidative damage in vitro. 2004 Clin. Chim. Acta pmid:15313158
Ballard TL et al. Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16620293
Bailey DG et al. Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. 2007 Clin. Pharmacol. Ther. pmid:17301733
Bailey DG et al. Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. 1993 Clin. Pharmacol. Ther. pmid:8275614
Bailey DG et al. Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin. 1993 Clin. Pharmacol. Ther. pmid:8513655
Bailey DG et al. Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. 2000 Clin. Pharmacol. Ther. pmid:11103749
Bailey DG et al. Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans. 1998 Clin. Pharmacol. Ther. pmid:9757148
Yamakawa Y et al. Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. 2011 Clin. Pharmacol. Ther. pmid:21633340
Luo Z et al. Effects of pH on the ability of flavonoids to act as Pickering emulsion stabilizers. 2012 Colloids Surf B Biointerfaces pmid:22197223
Parmar HS et al. DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. 2012 Diabetes Res. Clin. Pract. pmid:22410395
Drewnowski A et al. Genetic taste markers and food preferences. 2001 Drug Metab. Dispos. pmid:11259346
Miyazaki N et al. Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats. 2013 Drug Metab. Pharmacokinet. pmid:23419354
Shirasaka Y et al. Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. 2011 Drug Metab. Pharmacokinet. pmid:21206133
Lambev I et al. [Antiexudative effect of naringin in experimental pulmonary edema and peritonitis]. 1980 Eksp Med Morfol pmid:7460808
Oki K et al. The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. 2012 Endocrinology pmid:22798349
Liu M et al. Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. 2011 Environ. Toxicol. Pharmacol. pmid:21787720
Nowak-Solinska E et al. The effect of naringin on early growth and development of the spheno-occipital synchondrosis as measured by the expression of PTHrP and Sox9--an in vitro model. 2013 Eur J Orthod pmid:23172577
Sansone F et al. Physical characteristics and aerosol performance of naringin dry powders for pulmonary delivery prepared by spray-drying. 2009 Eur J Pharm Biopharm pmid:18996478
Mielczarek C Acid-base properties of selected flavonoid glycosides. 2005 Eur J Pharm Sci pmid:15911223
Rebello S et al. Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects. 2012 Eur. J. Clin. Pharmacol. pmid:22124880
Runkel M et al. Metabolic and analytical interactions of grapefruit juice and 1,2-benzopyrone (coumarin) in man. 1996 Eur. J. Clin. Pharmacol. pmid:8737764
Runkel M et al. The character of inhibition of the metabolism of 1,2-benzopyrone (coumarin) by grapefruit juice in human. 1997 Eur. J. Clin. Pharmacol. pmid:9476043
Gaur V et al. Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. 2009 Eur. J. Pharmacol. pmid:19577560
Wu JB et al. Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. 2008 Eur. J. Pharmacol. pmid:18495116
Kawaguchi K et al. Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. 1999 Eur. J. Pharmacol. pmid:10193661
Nie YC et al. Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. 2012 Eur. J. Pharmacol. pmid:22766066
Pari L and Amudha K Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. 2011 Eur. J. Pharmacol. pmid:20950607
Zhang P et al. Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. 2009 Eur. J. Pharmacol. pmid:19326565
Walker AL et al. Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. 2011 Exp. Hematol. pmid:21256917
Oliva J et al. Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. 2008 Exp. Mol. Pathol. pmid:18793633
Ang ES et al. Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. 2011 FEBS Lett. pmid:21835177
Iqbal MF and Zhu WY Bioactivation of flavonoid diglycosides by chicken cecal bacteria. 2009 FEMS Microbiol. Lett. pmid:19473248
Manzanares P et al. Purification and characterization of an alpha-L-rhamnosidase from Aspergillus niger. 1997 FEMS Microbiol. Lett. pmid:9435109