| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Uveitis, Posterior | D015866 | 5 associated lipids |
| Chromosomal Instability | D043171 | 5 associated lipids |
NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu M et al. | Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787720 |
| Oki K et al. | The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. | 2012 | Endocrinology | pmid:22798349 |
| Lambev I et al. | [Antiexudative effect of naringin in experimental pulmonary edema and peritonitis]. | 1980 | Eksp Med Morfol | pmid:7460808 |
| Miyazaki N et al. | Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats. | 2013 | Drug Metab. Pharmacokinet. | pmid:23419354 |
| Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. | 2011 | Drug Metab. Pharmacokinet. | pmid:21206133 |
| Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
| Parmar HS et al. | DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. | 2012 | Diabetes Res. Clin. Pract. | pmid:22410395 |
| Luo Z et al. | Effects of pH on the ability of flavonoids to act as Pickering emulsion stabilizers. | 2012 | Colloids Surf B Biointerfaces | pmid:22197223 |
| Bailey DG et al. | Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. | 2007 | Clin. Pharmacol. Ther. | pmid:17301733 |
| Bailey DG et al. | Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. | 1993 | Clin. Pharmacol. Ther. | pmid:8275614 |
| Bailey DG et al. | Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin. | 1993 | Clin. Pharmacol. Ther. | pmid:8513655 |
| Bailey DG et al. | Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. | 2000 | Clin. Pharmacol. Ther. | pmid:11103749 |
| Bailey DG et al. | Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans. | 1998 | Clin. Pharmacol. Ther. | pmid:9757148 |
| Yamakawa Y et al. | Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. | 2011 | Clin. Pharmacol. Ther. | pmid:21633340 |
| Ballard TL et al. | Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16620293 |
| Jeon SM et al. | Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. | 2002 | Clin. Chim. Acta | pmid:11814474 |
| Jagetia GC et al. | Influence of naringin on ferric iron induced oxidative damage in vitro. | 2004 | Clin. Chim. Acta | pmid:15313158 |
| Bailey DG et al. | Grapefruit juice and drugs. How significant is the interaction? | 1994 | Clin Pharmacokinet | pmid:8162660 |
| Jung UJ et al. | Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. | 2003 | Clin Nutr | pmid:14613759 |
| Jeon SM et al. | Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. | 2004 | Clin Nutr | pmid:15380892 |
| Caccamese S et al. | Chiral HPLC separation and CD spectra of the C-2 diastereomers of naringin in grapefruit during maturation. | 2003 | Chirality | pmid:12923803 |
| Gong HL et al. | Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats. | 2012 | Chin J Integr Med | pmid:22936325 |
| Wang JN et al. | Population pharmacokinetics of naringin in total flavonoids of Drynaria fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis. | 2012 | Chin J Integr Med | pmid:23239001 |
| Maehashi K et al. | Riboflavin-binding protein is a novel bitter inhibitor. | 2008 | Chem. Senses | pmid:17846099 |
| Dai H et al. | A highly sensitive and selective sensing ECL platform for naringin based on β-Cyclodextrin functionalized carbon nanohorns. | 2011 | Chem. Commun. (Camb.) | pmid:21975830 |
| Jagetia GC and Reddy TK | Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. | 2011 | Chem. Biol. Interact. | pmid:21345335 |
| Ozyürek M et al. | Novel oxime based flavanone, naringin-oxime: synthesis, characterization and screening for antioxidant activity. | 2014 | Chem. Biol. Interact. | pmid:24508591 |
| Amudha K and Pari L | Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. | 2011 | Chem. Biol. Interact. | pmid:21600195 |
| Shaik N et al. | Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. | 2012 | Cell. Physiol. Biochem. | pmid:22854627 |
| Seto E et al. | Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. | 1999 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10386788 |
| Ahmad SF et al. | Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines. | 2014 | Cell. Immunol. | pmid:24487035 |
| Krakstad C et al. | CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. | 2006 | Cell Death Differ. | pmid:16311514 |
| Blankson H et al. | Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. | 2000 | Cell Death Differ. | pmid:10918448 |
| Russo A et al. | Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. | 2000 | Cell Biol. Toxicol. | pmid:10917564 |
| Kim DI et al. | Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. | 2008 | Carcinogenesis | pmid:18296682 |
| Vanamala J et al. | Suppression of colon carcinogenesis by bioactive compounds in grapefruit. | 2006 | Carcinogenesis | pmid:16387741 |
| Pang WY et al. | Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. | 2010 | Br. J. Pharmacol. | pmid:20397301 |
| Yow TT et al. | Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. | 2011 | Br. J. Pharmacol. | pmid:21391982 |
| Sharma AK et al. | Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. | 2011 | Br. J. Nutr. | pmid:21736771 |
| Leray V et al. | Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. | 2011 | Br. J. Nutr. | pmid:22005428 |
| Tramice A et al. | Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. | 2008 | Biotechnol J | pmid:18098121 |
| Kometani T et al. | Synthesis of neohesperidin glycosides and naringin glycosides by cyclodextrin glucanotransferase from an alkalophilic Bacillus species. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8829532 |
| Kawaguchi K et al. | Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9028038 |
| Akiyama T et al. | Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129606 |
| Soria F and Ellenrieder G | Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224626 |
| Ichinose H et al. | Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis. | 2013 | Biosci. Biotechnol. Biochem. | pmid:23291751 |
| Liu Q et al. | Cell surface engineering of α-l-rhamnosidase for naringin hydrolysis. | 2012 | Bioresour. Technol. | pmid:22940311 |
| Martearena MR et al. | Synthesis of alkyl-alpha-L-rhamnosides by water soluble alcohols enzymatic glycosylation. | 2003 | Bioresour. Technol. | pmid:14575952 |
| Nunes MA et al. | Microtiter plates versus stirred mini-bioreactors in biocatalysis: a scalable approach. | 2013 | Bioresour. Technol. | pmid:23563437 |
| Liu M et al. | Metabolism and excretion studies of oral administered naringin, a putative antitussive, in rats and dogs. | 2012 | Biopharm Drug Dispos | pmid:22374702 |