NSC5548

NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.

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Introduction

To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with NSC5548?

NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with NSC5548

MeSH term MeSH ID Detail
Uveitis, Posterior D015866 5 associated lipids
Chromosomal Instability D043171 5 associated lipids
Endophthalmitis D009877 12 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Neuralgia D009437 28 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Per page 10 20 50 | Total 23

PubChem Associated disorders and diseases

What pathways are associated with NSC5548

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with NSC5548?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with NSC5548?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with NSC5548?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with NSC5548?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with NSC5548?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with NSC5548

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Per page 10 20 50 100 | Total 283
Authors Title Published Journal PubMed Link
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Jagetia GC and Reddy TK The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. 2002 Mutat. Res. pmid:12160890
Soria F and Ellenrieder G Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. 2002 Biosci. Biotechnol. Biochem. pmid:12224626
Tsai TH Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. 2002 J. Agric. Food Chem. pmid:12405759
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Kanno S et al. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. 2003 J. Pharmacol. Sci. pmid:12832847
Jagetia GC et al. Naringin, a citrus flavonone, protects against radiation-induced chromosome damage in mouse bone marrow. 2003 Mutagenesis pmid:12840107
Giannuzzo AN et al. Supercritical fluid extraction of naringin from the peel of Citrus paradisi. 2003 Jul-Aug Phytochem Anal pmid:12892417
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Caccamese S et al. Chiral HPLC separation and CD spectra of the C-2 diastereomers of naringin in grapefruit during maturation. 2003 Chirality pmid:12923803
Kanaze FI et al. Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations. 2003 J Pharm Biomed Anal pmid:12972089
Martearena MR et al. Synthesis of alkyl-alpha-L-rhamnosides by water soluble alcohols enzymatic glycosylation. 2003 Bioresour. Technol. pmid:14575952
Jung UJ et al. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. 2003 Clin Nutr pmid:14613759
Kim HJ et al. Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. 2004 Life Sci. pmid:14738906
Li X et al. LC-MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii. 2004 J Pharm Biomed Anal pmid:14738930
Kanno S et al. Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. 2004 Life Sci. pmid:15135655
Singh D and Chopra K The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. 2004 Pharmacol. Res. pmid:15177308
Singh D et al. Protective effect of naringin, a bioflavonoid on ferric nitrilotriacetate-induced oxidative renal damage in rat kidney. 2004 Toxicology pmid:15297014
Singh D et al. Protective effect of naringin, a bioflavonoid on glycerol-induced acute renal failure in rat kidney. 2004 Toxicology pmid:15297029
Jagetia GC et al. Influence of naringin on ferric iron induced oxidative damage in vitro. 2004 Clin. Chim. Acta pmid:15313158
Møller MT et al. Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. 2004 Toxicol. Sci. pmid:15342961
Kanaze FI et al. A validated solid-phase extraction HPLC method for the simultaneous determination of the citrus flavanone aglycones hesperetin and naringenin in urine. 2004 J Pharm Biomed Anal pmid:15351063
Yoo KM et al. Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. 2004 J. Agric. Food Chem. pmid:15366841
Jeon SM et al. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. 2004 Clin Nutr pmid:15380892
Samari HR et al. Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. 2005 Biochem. J. pmid:15461583
Jung UJ et al. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. 2004 J. Nutr. pmid:15465737
Zhang J and Brodbelt JS Screening flavonoid metabolites of naringin and narirutin in urine after human consumption of grapefruit juice by LC-MS and LC-MS/MS. 2004 Analyst pmid:15565223
Choi JS and Shin SC Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. 2005 Int J Pharm pmid:15725561
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Jagetia GC and Reddy TK Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. 2005 Life Sci. pmid:15936352
Huang ZF et al. [Study on quality control of effective fraction in qixue bingzhi decoction]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011278
Kim HJ and Choi JS Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits. 2005 Biopharm Drug Dispos pmid:16013069
Desiderio C et al. Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography. 2005 J Chromatogr A pmid:16013605
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Kanno S et al. Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. 2006 Life Sci. pmid:16137700
Tourniaire F et al. Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells. 2005 Mol Nutr Food Res pmid:16189799
Choi JS and Han HK Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. 2005 Int J Pharm pmid:16226412
Wong RW and Rabie AB Effect of naringin collagen graft on bone formation. 2006 Biomaterials pmid:16310246
Krakstad C et al. CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. 2006 Cell Death Differ. pmid:16311514
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Jung UJ et al. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. 2006 Int. J. Biochem. Cell Biol. pmid:16427799
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Clowers BH and Hill HH Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. 2006 J Mass Spectrom pmid:16498610
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Chen L et al. [Specific depletion of naringin from Si-Ni-San, a traditional Chinese prescription, by an immunoaffinity chromatography]. 2006 Se Pu pmid:16929840
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Asztemborska M and Zukowski J Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods. 2006 J Chromatogr A pmid:16970960
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Li K et al. Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography. 2006 Yakugaku Zasshi pmid:17077620
Rajadurai M and Stanely Mainzen Prince P Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. 2006 Toxicology pmid:17084010
Liu ZL et al. [Determination of three chemical components in Fructus aurantii immaturus]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17087081
Jagetia A et al. Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival. 2007 Mar-Apr J Appl Toxicol pmid:17177233
Rajadurai M and Stanely Mainzen Prince P Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. 2007 Toxicology pmid:17188415
Rajadurai M and Prince PS Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: an in vivo and in vitro study. 2007 Toxicology pmid:17289242
Bailey DG et al. Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. 2007 Clin. Pharmacol. Ther. pmid:17301733
Wang W et al. Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. 2007 J Chromatogr A pmid:17383667
Caccamese S et al. Racemization at C-2 of naringin in sour oranges with increasing maturity determined by chiral high-performance liquid chromatography. 2007 J. Agric. Food Chem. pmid:17417869
Uchiyama N et al. HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines. 2008 J Pharm Biomed Anal pmid:17532169
Martini LH et al. Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. 2007 Neurochem. Res. pmid:17577666
Qu QL et al. [Identification of jizhi syrup using HPLC fingerprint]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17608218
Ding L et al. Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. 2007 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:17689302
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Maehashi K et al. Riboflavin-binding protein is a novel bitter inhibitor. 2008 Chem. Senses pmid:17846099