NSC5548

NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.

Cross Reference

Introduction

To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with NSC5548?

NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with NSC5548

MeSH term MeSH ID Detail
Uveitis, Posterior D015866 5 associated lipids
Chromosomal Instability D043171 5 associated lipids
Endophthalmitis D009877 12 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Neuralgia D009437 28 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with NSC5548

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with NSC5548?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with NSC5548?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with NSC5548?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with NSC5548?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with NSC5548?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with NSC5548

Download all related citations
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Authors Title Published Journal PubMed Link
Demonty I et al. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. 2010 J. Nutr. pmid:20660284
Jung UJ et al. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. 2004 J. Nutr. pmid:15465737
Chanet A et al. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. 2012 J. Nutr. Biochem. pmid:21684135
Zhou X et al. Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. 2010 J. Orthop. Res. pmid:19824055
Wong RW and Rabie AB Effect of naringin on bone cells. 2006 J. Orthop. Res. pmid:16944474
Zhang L et al. Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. 2006 J. Pharm. Pharmacol. pmid:16945185
Lassoued MA et al. Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs. 2012 J. Pharm. Pharmacol. pmid:22420660
Shirasaka Y et al. Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. 2010 J. Pharmacol. Exp. Ther. pmid:19779132
Kanno S et al. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. 2003 J. Pharmacol. Sci. pmid:12832847
Zhao J et al. Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis. 2013 J. Pharmacol. Sci. pmid:23739595