NSC5548

NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.

Cross Reference

Introduction

To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with NSC5548?

NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with NSC5548

MeSH term MeSH ID Detail
Uveitis, Posterior D015866 5 associated lipids
Chromosomal Instability D043171 5 associated lipids
Endophthalmitis D009877 12 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Neuralgia D009437 28 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Per page 10 20 50 | Total 23

PubChem Associated disorders and diseases

What pathways are associated with NSC5548

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with NSC5548?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with NSC5548?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with NSC5548?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with NSC5548?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with NSC5548?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with NSC5548

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Per page 10 20 50 100 | Total 283
Authors Title Published Journal PubMed Link
Ang ES et al. Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. 2011 FEBS Lett. pmid:21835177
Liu M et al. Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. 2011 Environ. Toxicol. Pharmacol. pmid:21787720
Soria F et al. α-L-rhamnosidase of Aspergillus terreus immobilized on ferromagnetic supports. 2012 Appl. Microbiol. Biotechnol. pmid:21779843
Chen LL et al. Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. 2011 Arch. Oral Biol. pmid:21764032
Li L et al. Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. 2011 Phytomedicine pmid:21741227
Sharma AK et al. Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. 2011 Br. J. Nutr. pmid:21736771
Chanet A et al. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. 2012 J. Nutr. Biochem. pmid:21684135
Liu Y et al. Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. 2011 Int. Immunopharmacol. pmid:21640201
Yilmaz D et al. Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. 2012 Toxicol Ind Health pmid:21636685
Yamakawa Y et al. Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. 2011 Clin. Pharmacol. Ther. pmid:21633340
Amudha K and Pari L Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. 2011 Chem. Biol. Interact. pmid:21600195
Stohs SJ et al. Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. 2011 Int J Med Sci pmid:21537493
Catalán-Latorre A et al. In situ study of the effect of naringin, talinolol and protein-energy undernutrition on intestinal absorption of saquinavir in rats. 2011 Basic Clin. Pharmacol. Toxicol. pmid:21535410
Shirasaka Y et al. Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. 2011 J Pharm Sci pmid:21520088
Si-Si W et al. Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin. 2011 Pharm Biol pmid:21500970
Harapu CD et al. [Flavonoids--bioactive compounds in fruits juice]. 2010 Oct-Dec Rev Med Chir Soc Med Nat Iasi pmid:21500482
Kawaguchi K et al. Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin. 2011 Immunopharmacol Immunotoxicol pmid:21480758
Xu D and Cheng K [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21473151
Prota L et al. Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells. 2011 Int J Pharm pmid:21459138
Mangan RL et al. Grapefruit as a host for the West Indian fruit fly (Diptera: Tephritidae). 2011 J. Econ. Entomol. pmid:21404839
Yow TT et al. Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. 2011 Br. J. Pharmacol. pmid:21391982
Golechha M et al. Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. 2011 Biol. Pharm. Bull. pmid:21372385
Jagetia GC and Reddy TK Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. 2011 Chem. Biol. Interact. pmid:21345335
Walker AL et al. Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. 2011 Exp. Hematol. pmid:21256917
Santos ML et al. Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin. 2011 Molecules pmid:21245808
Rojas NL et al. Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus. 2011 J. Ind. Microbiol. Biotechnol. pmid:21221705
Shirasaka Y et al. Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. 2011 Drug Metab. Pharmacokinet. pmid:21206133
Jain M and Parmar HS Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. 2011 Inflamm. Res. pmid:21181230
KEENAN GL The occurrence of crystalline naringin on grapefruit rind. 1946 Science pmid:20995510
Pari L and Amudha K Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. 2011 Eur. J. Pharmacol. pmid:20950607
Puri M et al. Molecular characterization and enzymatic hydrolysis of naringin extracted from kinnow peel waste. 2011 Int. J. Biol. Macromol. pmid:20920523
Wang J et al. [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20862961
Bodas R et al. Naringin and vitamin E influence the oxidative stability and lipid profile of plasma in lambs fed fish oil. 2011 Res. Vet. Sci. pmid:20800247
Shirasaka Y et al. Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. 2010 Pharm. Res. pmid:20686826
Kumar A et al. Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. 2010 J Med Food pmid:20673063
Demonty I et al. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. 2010 J. Nutr. pmid:20660284
Gao S et al. Antitussive effect of naringin on experimentally induced cough in Guinea pigs. 2011 Planta Med. pmid:20645246
Li C et al. Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS. 2010 May-Jun J Chromatogr Sci pmid:20515525
Aggarwal A et al. Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. 2010 Life Sci. pmid:20433854
Cariño-Cortés R et al. Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes. 2010 Biol. Pharm. Bull. pmid:20410608
Belboukhari N et al. Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens. 2010 Nat. Prod. Res. pmid:20401799
Pang WY et al. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. 2010 Br. J. Pharmacol. pmid:20397301
Hu QY et al. [Traditional Chinese medicine Drynaria fortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells]. 2010 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:20175240
Xiong Y et al. [Naringin inhibits monocyte adhesion to high glucose-induced human umbilical vein endothelial cells]. 2010 Nan Fang Yi Ke Da Xue Xue Bao pmid:20159712
Gong HL et al. Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components. 2009 World J. Gastroenterol. pmid:20014465
Luo R et al. Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies. 2009 Yakugaku Zasshi pmid:19952535
Kumar A et al. Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. 2010 Food Chem. Toxicol. pmid:19941926
Caccamese S and Chillemi R Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography. 2010 J Chromatogr A pmid:19913235
Ding P et al. [Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells]. 2009 Zhongguo Zhong Yao Za Zhi pmid:19873788
Zhou X et al. Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. 2010 J. Orthop. Res. pmid:19824055