| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cachexia | D002100 | 21 associated lipids |
| Carcinoma 256, Walker | D002279 | 22 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shirasaka Y et al. | Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. | 2010 | J. Pharmacol. Exp. Ther. | pmid:19779132 |
| Kumar P and Kumar A | Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide. | 2010 | Behav. Brain Res. | pmid:19716383 |
| Koca U et al. | Decreasing unpalatable flavonoid components in Citrus: the effect of transformation construct. | 2009 | Physiol Plant | pmid:19656329 |
| Itoh K et al. | Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice. | 2009 | J Nat Med | pmid:19603253 |
| Chen JC et al. | [Anti-inflammatory effects and quantitative study of the combinations of active ingredients of Painong powder in mice]. | 2009 | Zhong Xi Yi Jie He Xue Bao | pmid:19583936 |
| Gaur V et al. | Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain. | 2009 | Eur. J. Pharmacol. | pmid:19577560 |
| Little TJ et al. | Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19535679 |
| Iqbal MF and Zhu WY | Bioactivation of flavonoid diglycosides by chicken cecal bacteria. | 2009 | FEMS Microbiol. Lett. | pmid:19473248 |
| Vij G et al. | Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant. | 2009 | Fundam Clin Pharmacol | pmid:19469804 |
| Qin XM et al. | Discrimination of three medicinal materials from the Citrus genus by HPLC fingerprint coupled with two complementary software. | 2009 Jul-Aug | Phytochem Anal | pmid:19425114 |
| Laska M et al. | Gustatory responsiveness to six bitter tastants in three species of nonhuman primates. | 2009 | J. Chem. Ecol. | pmid:19399556 |
| Beekwilder J et al. | Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus. | 2009 | Appl. Environ. Microbiol. | pmid:19346347 |
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| Ali MM et al. | Modulation of anticancer drug-induced P-glycoprotein expression by naringin. | 2009 Jan-Feb | Z. Naturforsch., C, J. Biosci. | pmid:19323275 |
| Choi JS and Kang KW | Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. | 2008 | Arch. Pharm. Res. | pmid:19099234 |
| Shirasaka Y et al. | Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). | 2009 | Pharm. Res. | pmid:19002566 |
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| Lee EJ et al. | Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. | 2008 | Food Chem. Toxicol. | pmid:18951945 |
| Rajadurai M and Prince PS | Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. | 2009 | Phytother Res | pmid:18844325 |
| Kanaze FI et al. | The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin. | 2009 | Biomed. Chromatogr. | pmid:18823075 |
| Oliva J et al. | Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. | 2008 | Exp. Mol. Pathol. | pmid:18793633 |
| Attia SM | Abatement by naringin of lomefloxacin-induced genomic instability in mice. | 2008 | Mutagenesis | pmid:18755759 |
| Koseki T et al. | Characterization of an alpha-L-rhamnosidase from Aspergillus kawachii and its gene. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18633609 |
| Wu JB et al. | Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts. | 2008 | Eur. J. Pharmacol. | pmid:18495116 |
| Punithavathi VR et al. | Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats. | 2008 | J Appl Toxicol | pmid:18344197 |
| Zhang LH et al. | [Optimal extraction of Dingxiang jiangqi granules]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309666 |
| Kim DI et al. | Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. | 2008 | Carcinogenesis | pmid:18296682 |
| Tsui VW et al. | The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. | 2008 | Phytother Res | pmid:18167053 |
| Tramice A et al. | Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. | 2008 | Biotechnol J | pmid:18098121 |
| Go YH et al. | Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids. | 2007 | J. Microbiol. Biotechnol. | pmid:18062236 |
| Rajadurai M and Prince PS | Preventive effect of naringin on cardiac mitochondrial enzymes during isoproterenol-induced myocardial infarction in rats: a transmission electron microscopic study. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17994577 |
| Pereira RM et al. | Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity. | 2007 | Molecules | pmid:17909491 |
| Mello LD et al. | Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)-naringin complex. | 2007 | J Pharm Biomed Anal | pmid:17881180 |
| Maehashi K et al. | Riboflavin-binding protein is a novel bitter inhibitor. | 2008 | Chem. Senses | pmid:17846099 |
| Wei M et al. | Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model. | 2007 | Am. J. Chin. Med. | pmid:17708632 |
| Ding L et al. | Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17689302 |
| Qu QL et al. | [Identification of jizhi syrup using HPLC fingerprint]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17608218 |
| Martini LH et al. | Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. | 2007 | Neurochem. Res. | pmid:17577666 |
| Uchiyama N et al. | HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines. | 2008 | J Pharm Biomed Anal | pmid:17532169 |
| Caccamese S et al. | Racemization at C-2 of naringin in sour oranges with increasing maturity determined by chiral high-performance liquid chromatography. | 2007 | J. Agric. Food Chem. | pmid:17417869 |
| Wang W et al. | Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. | 2007 | J Chromatogr A | pmid:17383667 |
| Bailey DG et al. | Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. | 2007 | Clin. Pharmacol. Ther. | pmid:17301733 |
| Rajadurai M and Prince PS | Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: an in vivo and in vitro study. | 2007 | Toxicology | pmid:17289242 |
| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. | 2007 | Toxicology | pmid:17188415 |
| Jagetia A et al. | Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival. | 2007 Mar-Apr | J Appl Toxicol | pmid:17177233 |
| Liu ZL et al. | [Determination of three chemical components in Fructus aurantii immaturus]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17087081 |
| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. | 2006 | Toxicology | pmid:17084010 |
| Li K et al. | Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography. | 2006 | Yakugaku Zasshi | pmid:17077620 |
| Lim SC and Choi JS | Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. | 2006 | Biopharm Drug Dispos | pmid:17009338 |
| Asztemborska M and Zukowski J | Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods. | 2006 | J Chromatogr A | pmid:16970960 |