| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cachexia | D002100 | 21 associated lipids |
| Carcinoma 256, Walker | D002279 | 22 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Choi JS and Kang KW | Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin. | 2008 | Arch. Pharm. Res. | pmid:19099234 |
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| Tsui VW et al. | The inhibitory effects of naringin on the growth of periodontal pathogens in vitro. | 2008 | Phytother Res | pmid:18167053 |
| Jagetia A et al. | Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival. | 2007 Mar-Apr | J Appl Toxicol | pmid:17177233 |
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| Rajadurai M and Prince PS | Preventive effect of naringin on isoproterenol-induced cardiotoxicity in Wistar rats: an in vivo and in vitro study. | 2007 | Toxicology | pmid:17289242 |
| Wang W et al. | Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection. | 2007 | J Chromatogr A | pmid:17383667 |
| Bailey DG et al. | Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. | 2007 | Clin. Pharmacol. Ther. | pmid:17301733 |
| Martini LH et al. | Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. | 2007 | Neurochem. Res. | pmid:17577666 |
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| Go YH et al. | Functional characteristics of cyclodextrin glucanotransferase from alkalophilic Bacillus sp. BL-31 highly specific for intermolecular transglycosylation of bioflavonoids. | 2007 | J. Microbiol. Biotechnol. | pmid:18062236 |
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| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats. | 2007 | Toxicology | pmid:17188415 |
| Mello LD et al. | Electrochemical and spectroscopic characterization of the interaction between DNA and Cu(II)-naringin complex. | 2007 | J Pharm Biomed Anal | pmid:17881180 |
| Wong RW and Rabie AB | Effect of naringin collagen graft on bone formation. | 2006 | Biomaterials | pmid:16310246 |
| Krakstad C et al. | CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. | 2006 | Cell Death Differ. | pmid:16311514 |
| Vanamala J et al. | Suppression of colon carcinogenesis by bioactive compounds in grapefruit. | 2006 | Carcinogenesis | pmid:16387741 |
| Asztemborska M and Zukowski J | Determination of diastereomerization barrier of some flavanones by high-performance liquid chromatography methods. | 2006 | J Chromatogr A | pmid:16970960 |
| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on lipids, lipoproteins and lipid metabolic enzymes in isoproterenol-induced myocardial infarction in Wistar rats. | 2006 | J. Biochem. Mol. Toxicol. | pmid:16906524 |
| Chen L et al. | [Specific depletion of naringin from Si-Ni-San, a traditional Chinese prescription, by an immunoaffinity chromatography]. | 2006 | Se Pu | pmid:16929840 |
| Clowers BH and Hill HH | Influence of cation adduction on the separation characteristics of flavonoid diglycoside isomers using dual gate-ion mobility-quadrupole ion trap mass spectrometry. | 2006 | J Mass Spectrom | pmid:16498610 |
| Katsoura MH et al. | Use of ionic liquids as media for the biocatalytic preparation of flavonoid derivatives with antioxidant potency. | 2006 | J. Biotechnol. | pmid:16457903 |
| Jung UJ et al. | Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. | 2006 | Int. J. Biochem. Cell Biol. | pmid:16427799 |
| Yeum CH and Choi JS | Effect of naringin pretreatment on bioavailability of verapamil in rabbits. | 2006 | Arch. Pharm. Res. | pmid:16491851 |
| Li K et al. | Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography. | 2006 | Yakugaku Zasshi | pmid:17077620 |
| Rajadurai M and Stanely Mainzen Prince P | Preventive effect of naringin on lipid peroxides and antioxidants in isoproterenol-induced cardiotoxicity in Wistar rats: biochemical and histopathological evidences. | 2006 | Toxicology | pmid:17084010 |
| Wong RW and Rabie AB | Effect of naringin on bone cells. | 2006 | J. Orthop. Res. | pmid:16944474 |
| Zhang L et al. | Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. | 2006 | J. Pharm. Pharmacol. | pmid:16945185 |
| Liu ZL et al. | [Determination of three chemical components in Fructus aurantii immaturus]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17087081 |
| Ballard TL et al. | Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16620293 |
| Zhou DY et al. | Identification of O-diglycosyl flavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. | 2006 | J Pharm Biomed Anal | pmid:16837161 |
| Kanno S et al. | Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. | 2006 | Life Sci. | pmid:16137700 |
| Lim SC and Choi JS | Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats. | 2006 | Biopharm Drug Dispos | pmid:17009338 |
| Kim HJ and Choi JS | Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits. | 2005 | Biopharm Drug Dispos | pmid:16013069 |
| Gorinstein S et al. | Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. | 2005 | J. Agric. Food Chem. | pmid:15826081 |
| Choi JS and Han HK | Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. | 2005 | Int J Pharm | pmid:16226412 |
| Samari HR et al. | Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins. | 2005 | Biochem. J. | pmid:15461583 |
| Desiderio C et al. | Analysis of flavanone-7-O-glycosides in citrus juices by short-end capillary electrochromatography. | 2005 | J Chromatogr A | pmid:16013605 |
| Choi JS and Shin SC | Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats. | 2005 | Int J Pharm | pmid:15725561 |
| Mielczarek C | Acid-base properties of selected flavonoid glycosides. | 2005 | Eur J Pharm Sci | pmid:15911223 |
| Jagetia GC and Reddy TK | Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. | 2005 | Life Sci. | pmid:15936352 |
| Huang ZF et al. | [Study on quality control of effective fraction in qixue bingzhi decoction]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011278 |
| Tourniaire F et al. | Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells. | 2005 | Mol Nutr Food Res | pmid:16189799 |
| Jeon SM et al. | Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. | 2004 | Clin Nutr | pmid:15380892 |
| Singh D et al. | Protective effect of naringin, a bioflavonoid on ferric nitrilotriacetate-induced oxidative renal damage in rat kidney. | 2004 | Toxicology | pmid:15297014 |