| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Cachexia | D002100 | 21 associated lipids |
| Carcinoma 256, Walker | D002279 | 22 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
NSC5548
NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
Cross Reference
Introduction
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with NSC5548?
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with NSC5548
PubChem Associated disorders and diseases
What pathways are associated with NSC5548
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with NSC5548?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with NSC5548?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with NSC5548?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with NSC5548?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with NSC5548?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with NSC5548
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu C et al. | [Study on technology in preparation of Fructus Auranti extract]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22308686 |
| Kandhare AD et al. | Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. | 2012 | Fitoterapia | pmid:22343014 |
| Liu M et al. | Metabolism and excretion studies of oral administered naringin, a putative antitussive, in rats and dogs. | 2012 | Biopharm Drug Dispos | pmid:22374702 |
| Parmar HS et al. | DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. | 2012 | Diabetes Res. Clin. Pract. | pmid:22410395 |
| Lassoued MA et al. | Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs. | 2012 | J. Pharm. Pharmacol. | pmid:22420660 |
| Rong W et al. | Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury. | 2012 | Neurochem. Res. | pmid:22453521 |
| Liu T et al. | Aspergillus niger DLFCC-90 rhamnoside hydrolase, a new type of flavonoid glycoside hydrolase. | 2012 | Appl. Environ. Microbiol. | pmid:22544243 |
| Bodas R et al. | The liver antioxidant status of fattening lambs is improved by naringin dietary supplementation at 0.15% rates but not meat quality. | 2012 | Animal | pmid:22558934 |
| Kwatra D et al. | Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism. | 2012 | Mol. Pharm. | pmid:22676443 |
| Liu MH et al. | Study on impurities in naringin extracted from Citrus grandis 'tomentosa'. | 2012 | Zhong Yao Cai | pmid:22734411 |
| Wang D et al. | Long-term naringin consumption reverses a glucose uptake defect and improves cognitive deficits in a mouse model of Alzheimer's disease. | 2012 | Pharmacol. Biochem. Behav. | pmid:22741174 |
| Nie YC et al. | Naringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways. | 2012 | Eur. J. Pharmacol. | pmid:22766066 |
| Oki K et al. | The potassium channel, Kir3.4 participates in angiotensin II-stimulated aldosterone production by a human adrenocortical cell line. | 2012 | Endocrinology | pmid:22798349 |
| Liu Y et al. | [Transdermal behavior of effective constituents in xuanbi gel plaster]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22803360 |
| Mahmoud AM et al. | Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats. | 2012 Nov-Dec | J. Diabetes Complicat. | pmid:22809898 |
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| Yadav V et al. | Alpha-L-rhamnosidase from Aspergillus clavato-nanicus MTCC-9611 active at alkaline pH. | 2012 May-Jun | Prikl. Biokhim. Mikrobiol. | pmid:22834305 |
| Ramesh E and Alshatwi AA | Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. | 2013 | Food Chem. Toxicol. | pmid:22847135 |
| Shaik N et al. | Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin. | 2012 | Cell. Physiol. Biochem. | pmid:22854627 |
| Gopinath K and Sudhandiran G | Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. | 2012 | Neuroscience | pmid:22871521 |
| Huang W et al. | Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus aurantii-type formulae. | 2012 | Pharmazie | pmid:22888512 |
| Gong HL et al. | Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats. | 2012 | Chin J Integr Med | pmid:22936325 |
| Liu Q et al. | Cell surface engineering of α-l-rhamnosidase for naringin hydrolysis. | 2012 | Bioresour. Technol. | pmid:22940311 |
| Zhang J et al. | Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. | 2012 | Food Chem | pmid:22953882 |
| Uckoo RM et al. | Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. | 2012 | J. Food Sci. | pmid:22957912 |
| Liu Y et al. | Naringin inhibits chemokine production in an LPS-induced RAW 264.7 macrophage cell line. | 2012 | Mol Med Rep | pmid:22965302 |
| Nie YC et al. | Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats. | 2012 | J Med Food | pmid:22985397 |
| Nunes MA et al. | High-affinity water-soluble system for efficient naringinase immobilization in polyvinyl alcohol-dimethyl sulfoxide lens-shaped particles. | 2012 | J. Mol. Recognit. | pmid:23108618 |
| Yu X et al. | Inhibiting wear particles-induced osteolysis with naringin. | 2013 | Int Orthop | pmid:23111634 |
| Nowak-Solinska E et al. | The effect of naringin on early growth and development of the spheno-occipital synchondrosis as measured by the expression of PTHrP and Sox9--an in vitro model. | 2013 | Eur J Orthod | pmid:23172577 |
| Wang JN et al. | Population pharmacokinetics of naringin in total flavonoids of Drynaria fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis. | 2012 | Chin J Integr Med | pmid:23239001 |
| Chen Y et al. | Purification and characterization of a naringinase from Aspergillus aculeatus JMUdb058. | 2013 | J. Agric. Food Chem. | pmid:23289582 |
| Ichinose H et al. | Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis. | 2013 | Biosci. Biotechnol. Biochem. | pmid:23291751 |
| Arnao MB et al. | An enzymatic colorimetric method for measuring naringin using 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS) in the presence of peroxidase. | 1990 | Anal. Biochem. | pmid:2339789 |
| Miyazaki N et al. | Effects of itraconazole, dexamethasone and naringin on the pharmacokinetics of nadolol in rats. | 2013 | Drug Metab. Pharmacokinet. | pmid:23419354 |
| Alam MA et al. | Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. | 2013 | Nutrients | pmid:23446977 |
| Prakash A et al. | Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. | 2013 | Int. J. Neurosci. | pmid:23510099 |
| Zhang X et al. | Investigation of the interaction of naringin palmitate with bovine serum albumin: spectroscopic analysis and molecular docking. | 2013 | PLoS ONE | pmid:23527100 |
| Li N et al. | Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis. | 2013 | J Orthop Sci | pmid:23553541 |
| Nunes MA et al. | Microtiter plates versus stirred mini-bioreactors in biocatalysis: a scalable approach. | 2013 | Bioresour. Technol. | pmid:23563437 |
| Zhai YK et al. | [Effects of naringin on proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596885 |
| Chen Y et al. | Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. | 2013 | Food Chem. Toxicol. | pmid:23603004 |
| Li H et al. | Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. | 2013 | Toxicol. Lett. | pmid:23694763 |
| Huang H et al. | Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway. | 2013 | Int. J. Mol. Med. | pmid:23732220 |
| Zhao J et al. | Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis. | 2013 | J. Pharmacol. Sci. | pmid:23739595 |
| Li P et al. | Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats. | 2013 | Food Chem. Toxicol. | pmid:23871784 |
| Ni H et al. | Development and evaluation of an HPLC method for accurate determinations of enzyme activities of naringinase complex. | 2013 | J. Agric. Food Chem. | pmid:24070201 |
| Jang Y et al. | Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats. | 2013 | Pharmacology | pmid:24080610 |
| Luo YL et al. | Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure. | 2013 | Inflamm. Res. | pmid:24085318 |
| Chen J et al. | Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24118820 |