NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Ang ES et al. | Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation. | 2011 | FEBS Lett. | pmid:21835177 |
Liu M et al. | Toxicokinetics of naringin, a putative antitussive, after 184-day repeated oral administration in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:21787720 |
Soria F et al. | α-L-rhamnosidase of Aspergillus terreus immobilized on ferromagnetic supports. | 2012 | Appl. Microbiol. Biotechnol. | pmid:21779843 |
Chen LL et al. | Osteogenic effect of Drynariae rhizoma extracts and Naringin on MC3T3-E1 cells and an induced rat alveolar bone resorption model. | 2011 | Arch. Oral Biol. | pmid:21764032 |
Li L et al. | Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1. | 2011 | Phytomedicine | pmid:21741227 |
Sharma AK et al. | Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. | 2011 | Br. J. Nutr. | pmid:21736771 |
Chanet A et al. | Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. | 2012 | J. Nutr. Biochem. | pmid:21684135 |
Liu Y et al. | Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. | 2011 | Int. Immunopharmacol. | pmid:21640201 |
Yilmaz D et al. | Influence of naringin on cadmium-induced genomic damage in human lymphocytes in vitro. | 2012 | Toxicol Ind Health | pmid:21636685 |
Yamakawa Y et al. | Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. | 2011 | Clin. Pharmacol. Ther. | pmid:21633340 |
Amudha K and Pari L | Beneficial role of naringin, a flavanoid on nickel induced nephrotoxicity in rats. | 2011 | Chem. Biol. Interact. | pmid:21600195 |
Stohs SJ et al. | Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. | 2011 | Int J Med Sci | pmid:21537493 |
Catalán-Latorre A et al. | In situ study of the effect of naringin, talinolol and protein-energy undernutrition on intestinal absorption of saquinavir in rats. | 2011 | Basic Clin. Pharmacol. Toxicol. | pmid:21535410 |
Shirasaka Y et al. | Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein. | 2011 | J Pharm Sci | pmid:21520088 |
Si-Si W et al. | Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin. | 2011 | Pharm Biol | pmid:21500970 |
Harapu CD et al. | [Flavonoids--bioactive compounds in fruits juice]. | 2010 Oct-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:21500482 |
Kawaguchi K et al. | Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin. | 2011 | Immunopharmacol Immunotoxicol | pmid:21480758 |
Xu D and Cheng K | [Determination of liquiritin, naringin, hesperidin and glycyrrhizic acid in extractive of Wendan formula by RP-HPLC]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21473151 |
Prota L et al. | Leucine enhances aerosol performance of naringin dry powder and its activity on cystic fibrosis airway epithelial cells. | 2011 | Int J Pharm | pmid:21459138 |
Mangan RL et al. | Grapefruit as a host for the West Indian fruit fly (Diptera: Tephritidae). | 2011 | J. Econ. Entomol. | pmid:21404839 |
Yow TT et al. | Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. | 2011 | Br. J. Pharmacol. | pmid:21391982 |
Golechha M et al. | Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. | 2011 | Biol. Pharm. Bull. | pmid:21372385 |
Jagetia GC and Reddy TK | Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. | 2011 | Chem. Biol. Interact. | pmid:21345335 |
Walker AL et al. | Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. | 2011 | Exp. Hematol. | pmid:21256917 |
Santos ML et al. | Modulation of the pharmacological activities of secretory phospholipase A2 from Crotalus durissus cascavella induced by naringin. | 2011 | Molecules | pmid:21245808 |
Rojas NL et al. | Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus. | 2011 | J. Ind. Microbiol. Biotechnol. | pmid:21221705 |
Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. | 2011 | Drug Metab. Pharmacokinet. | pmid:21206133 |
Jain M and Parmar HS | Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. | 2011 | Inflamm. Res. | pmid:21181230 |
KEENAN GL | The occurrence of crystalline naringin on grapefruit rind. | 1946 | Science | pmid:20995510 |
Pari L and Amudha K | Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats. | 2011 | Eur. J. Pharmacol. | pmid:20950607 |
Puri M et al. | Molecular characterization and enzymatic hydrolysis of naringin extracted from kinnow peel waste. | 2011 | Int. J. Biol. Macromol. | pmid:20920523 |
Wang J et al. | [Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in xiao'erjinning oral liquid by an HPLC method]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20862961 |
Bodas R et al. | Naringin and vitamin E influence the oxidative stability and lipid profile of plasma in lambs fed fish oil. | 2011 | Res. Vet. Sci. | pmid:20800247 |
Shirasaka Y et al. | Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide. | 2010 | Pharm. Res. | pmid:20686826 |
Kumar A et al. | Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. | 2010 | J Med Food | pmid:20673063 |
Demonty I et al. | The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. | 2010 | J. Nutr. | pmid:20660284 |
Gao S et al. | Antitussive effect of naringin on experimentally induced cough in Guinea pigs. | 2011 | Planta Med. | pmid:20645246 |
Li C et al. | Simultaneous determination of neoeriocitrin and naringin in rat plasma after oral administration of a Chinese compound formulation by UPLC-MS-MS. | 2010 May-Jun | J Chromatogr Sci | pmid:20515525 |
Aggarwal A et al. | Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice. | 2010 | Life Sci. | pmid:20433854 |
Cariño-Cortés R et al. | Effect of naringin on the DNA damage induced by daunorubicin in mouse hepatocytes and cardiocytes. | 2010 | Biol. Pharm. Bull. | pmid:20410608 |
Belboukhari N et al. | Chiral separation of hesperidin and naringin and its analysis in a butanol extract of Launeae arborescens. | 2010 | Nat. Prod. Res. | pmid:20401799 |
Pang WY et al. | Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. | 2010 | Br. J. Pharmacol. | pmid:20397301 |
Hu QY et al. | [Traditional Chinese medicine Drynaria fortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells]. | 2010 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:20175240 |
Xiong Y et al. | [Naringin inhibits monocyte adhesion to high glucose-induced human umbilical vein endothelial cells]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20159712 |
Gong HL et al. | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components. | 2009 | World J. Gastroenterol. | pmid:20014465 |
Luo R et al. | Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies. | 2009 | Yakugaku Zasshi | pmid:19952535 |
Kumar A et al. | Naringin alleviates cognitive impairment, mitochondrial dysfunction and oxidative stress induced by D-galactose in mice. | 2010 | Food Chem. Toxicol. | pmid:19941926 |
Caccamese S and Chillemi R | Racemization at C-2 of naringin in pummelo (Citrus grandis) with increasing maturity determined by chiral high-performance liquid chromatography. | 2010 | J Chromatogr A | pmid:19913235 |
Ding P et al. | [Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19873788 |
Zhou X et al. | Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model. | 2010 | J. Orthop. Res. | pmid:19824055 |