NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Li XL et al. | [Determination of hesperidin and naringin in Fructus Aurantii Immaturus and Fructus Aurantii by reversed-phase high performance liquid chromatography]. | 2002 | Se Pu | pmid:12683015 |
Xiao M et al. | [Determination of naringin and synephrine in fructus aurantii from different habitats by HPLC]. | 2000 | Zhong Yao Cai | pmid:12575153 |
Hu Y et al. | [Pharmacognostical identification of one Rhizoma Drynariae habitually used species from Yunnan]. | 2000 | Zhong Yao Cai | pmid:12575083 |
Tsai TH | Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. | 2002 | J. Agric. Food Chem. | pmid:12405759 |
Soria F and Ellenrieder G | Thermal inactivation and product inhibition of Aspergillus terreus CECT 2663 alpha-L-rhamnosidase and their role on hydrolysis of naringin solutions. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224626 |
Jagetia GC and Reddy TK | The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. | 2002 | Mutat. Res. | pmid:12160890 |
Larsen AK et al. | Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes. | 2002 | J. Biol. Chem. | pmid:12095991 |
Ohtani M et al. | [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine]. | 2002 | Yakugaku Zasshi | pmid:12040751 |
Scaroni E et al. | Hydrolytic properties of crude alpha-L-rhamnosidases produced by several wild strains of mesophilic fungi. | 2002 | Lett. Appl. Microbiol. | pmid:12028430 |
Elinbaum S et al. | Production of Aspergillus terreus alpha-L-rhamnosidase by solid state fermentation. | 2002 | Lett. Appl. Microbiol. | pmid:11849496 |
Jeon SM et al. | Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. | 2002 | Clin. Chim. Acta | pmid:11814474 |
da Silva RR et al. | [Hypocholesterolemic effect of naringin and rutin flavonoids]. | 2001 | Arch Latinoam Nutr | pmid:11795241 |
Ramesh N et al. | Phytochemical and antimicrobial studies on Drynaria quercifolia. | 2001 | Fitoterapia | pmid:11731121 |
Jeon SM et al. | Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. | 2001 | Life Sci. | pmid:11720089 |
Choe SC et al. | Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits. | 2001 | J. Cardiovasc. Pharmacol. | pmid:11707699 |
Wang Y and Li J | [Qualitative identification and quantitative determination of naringin in rhizoma Drynariae by TLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599350 |
Choi MS et al. | Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. | 2001 | Ann. Nutr. Metab. | pmid:11585976 |
Alvarez-González I et al. | Inhibitory effect of naringin on the micronuclei induced by ifosfamide in mouse, and evaluation of its modulatory effect on the Cyp3a subfamily. | 2001 | Mutat. Res. | pmid:11506811 |
Drewnowski A et al. | Genetic taste markers and food preferences. | 2001 | Drug Metab. Dispos. | pmid:11259346 |
Akiyama T et al. | Naringin glycosides alpha-glucosylated on ring B found in the natural food additive, enzymatically modified naringin. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129606 |
Bailey DG et al. | Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. | 2000 | Clin. Pharmacol. Ther. | pmid:11103749 |
Widmer W | Determination of naringin and neohesperidin in orange juice by liquid chromatography with UV detection to detect the presence of grapefruit juice: Collaborative Study. | 2000 Sep-Oct | J AOAC Int | pmid:11048857 |
Berven G et al. | Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells. | 2001 Feb-Mar | Toxicon | pmid:10978754 |
Blankson H et al. | Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. | 2000 | Cell Death Differ. | pmid:10918448 |
Russo A et al. | Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. | 2000 | Cell Biol. Toxicol. | pmid:10917564 |
Cohen MF and Yamasaki H | Flavonoid-induced expression of a symbiosis-related gene in the cyanobacterium Nostoc punctiforme. | 2000 | J. Bacteriol. | pmid:10913102 |
Jung DM et al. | Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy. | 2000 | J. Agric. Food Chem. | pmid:10691648 |
Ishii K et al. | Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. | 2000 | J. Agric. Food Chem. | pmid:10637051 |
Zverlov VV et al. | The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. | 2000 | Mol. Microbiol. | pmid:10632887 |
Lee SJ et al. | Transglycosylation of naringin by Bacillus stearothermophilusMaltogenic amylase to give glycosylated naringin. | 1999 | J. Agric. Food Chem. | pmid:10552702 |
Shin YW et al. | Hypocholesterolemic effect of naringin associated with hepatic cholesterol regulating enzyme changes in rats. | 1999 | Int J Vitam Nutr Res | pmid:10526779 |
Seto E et al. | Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. | 1999 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10386788 |
Kawaguchi K et al. | Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. | 1999 | Eur. J. Pharmacol. | pmid:10193661 |