NSC5548 is a lipid of Polyketides (PK) class. Nsc5548 is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Hyperglycemia, Coronary Arteriosclerosis, Liver diseases and Pulmonary Edema. The involved functions are known as Increased Sensitivy, Taste Perception, Cell Death, Phosphorylation and Signal Transduction. Nsc5548 often locates in Oral region, Cytoskeleton, Hepatic, Blood and Mouse Bone Marrow. The associated genes with NSC5548 are CA2 gene, P4HTM gene, FPGT gene, glycyl-L-phenylalanine and glycylphenylalanine. The related lipids are butyrate, Lipid Peroxides, blood lipid, Sterols and Total cholesterol.
To understand associated biological information of NSC5548, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
NSC5548 is suspected in Hyperglycemia, Osteoporosis, Diabetes Mellitus, Non-Insulin-Dependent, Coronary Arteriosclerosis, Liver diseases, Pulmonary Edema and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with NSC5548
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chen J et al. | Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells. | 2014 | Int. J. Mol. Med. | pmid:24399619 |
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Li S et al. | Content changes of bitter compounds in 'Guoqing No.1' Satsuma mandarin (Citrus unshiu Marc.) during fruit development of consecutive 3 seasons. | 2014 | Food Chem | pmid:24128570 |
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Jang Y et al. | Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats. | 2013 | Pharmacology | pmid:24080610 |
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Zhao J et al. | Pharmacokinetic and pharmacodynamic studies of four major phytochemical components of Da-Cheng-Qi decoction to treat acute pancreatitis. | 2013 | J. Pharmacol. Sci. | pmid:23739595 |
Huang H et al. | Naringin inhibits high glucose-induced cardiomyocyte apoptosis by attenuating mitochondrial dysfunction and modulating the activation of the p38 signaling pathway. | 2013 | Int. J. Mol. Med. | pmid:23732220 |
Li H et al. | Naringin inhibits growth potential of human triple-negative breast cancer cells by targeting β-catenin signaling pathway. | 2013 | Toxicol. Lett. | pmid:23694763 |
Chen Y et al. | Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice. | 2013 | Food Chem. Toxicol. | pmid:23603004 |
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Li N et al. | Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis. | 2013 | J Orthop Sci | pmid:23553541 |
Zhang X et al. | Investigation of the interaction of naringin palmitate with bovine serum albumin: spectroscopic analysis and molecular docking. | 2013 | PLoS ONE | pmid:23527100 |
Prakash A et al. | Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. | 2013 | Int. J. Neurosci. | pmid:23510099 |
Alam MA et al. | Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. | 2013 | Nutrients | pmid:23446977 |
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Arnao MB et al. | An enzymatic colorimetric method for measuring naringin using 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid)(ABTS) in the presence of peroxidase. | 1990 | Anal. Biochem. | pmid:2339789 |
Ichinose H et al. | Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis. | 2013 | Biosci. Biotechnol. Biochem. | pmid:23291751 |
Chen Y et al. | Purification and characterization of a naringinase from Aspergillus aculeatus JMUdb058. | 2013 | J. Agric. Food Chem. | pmid:23289582 |
Wang JN et al. | Population pharmacokinetics of naringin in total flavonoids of Drynaria fortunei (Kunze) J. Sm. in Chinese women with primary osteoporosis. | 2012 | Chin J Integr Med | pmid:23239001 |
Nowak-Solinska E et al. | The effect of naringin on early growth and development of the spheno-occipital synchondrosis as measured by the expression of PTHrP and Sox9--an in vitro model. | 2013 | Eur J Orthod | pmid:23172577 |
Yu X et al. | Inhibiting wear particles-induced osteolysis with naringin. | 2013 | Int Orthop | pmid:23111634 |
Nunes MA et al. | High-affinity water-soluble system for efficient naringinase immobilization in polyvinyl alcohol-dimethyl sulfoxide lens-shaped particles. | 2012 | J. Mol. Recognit. | pmid:23108618 |
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Liu Y et al. | Naringin inhibits chemokine production in an LPS-induced RAW 264.7 macrophage cell line. | 2012 | Mol Med Rep | pmid:22965302 |
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Zhang J et al. | Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. | 2012 | Food Chem | pmid:22953882 |
Liu Q et al. | Cell surface engineering of α-l-rhamnosidase for naringin hydrolysis. | 2012 | Bioresour. Technol. | pmid:22940311 |
Gong HL et al. | Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats. | 2012 | Chin J Integr Med | pmid:22936325 |
Huang W et al. | Simultaneous UPLC analysis of three major flavonoids in granule decoctions of Fructus aurantii-type formulae. | 2012 | Pharmazie | pmid:22888512 |
Gopinath K and Sudhandiran G | Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. | 2012 | Neuroscience | pmid:22871521 |
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Ramesh E and Alshatwi AA | Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells. | 2013 | Food Chem. Toxicol. | pmid:22847135 |
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Bodas R et al. | The liver antioxidant status of fattening lambs is improved by naringin dietary supplementation at 0.15% rates but not meat quality. | 2012 | Animal | pmid:22558934 |
Liu T et al. | Aspergillus niger DLFCC-90 rhamnoside hydrolase, a new type of flavonoid glycoside hydrolase. | 2012 | Appl. Environ. Microbiol. | pmid:22544243 |
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Parmar HS et al. | DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study. | 2012 | Diabetes Res. Clin. Pract. | pmid:22410395 |
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Viswanatha GL et al. | Amelioration of immobilization stress-induced biochemical and behavioral alterations and mitochondrial dysfunction by naringin in mice: possible mechanism of nitric oxide modulation. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088593 |
Kim SW et al. | Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22074828 |
Leray V et al. | Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. | 2011 | Br. J. Nutr. | pmid:22005428 |
Yu HY et al. | Anti-platelet effects of yuzu extract and its component. | 2011 | Food Chem. Toxicol. | pmid:22005257 |
Dai H et al. | A highly sensitive and selective sensing ECL platform for naringin based on β-Cyclodextrin functionalized carbon nanohorns. | 2011 | Chem. Commun. (Camb.) | pmid:21975830 |
Xulu S and Oroma Owira PM | Naringin ameliorates atherogenic dyslipidemia but not hyperglycemia in rats with type 1 diabetes. | 2012 | J. Cardiovasc. Pharmacol. | pmid:21964158 |
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Gopinath K et al. | Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis. | 2011 | Neurochem. Int. | pmid:21945202 |
A Bakheet S and M Attia S | Evaluation of chromosomal instability in diabetic rats treated with naringin. | 2011 | Oxid Med Cell Longev | pmid:21941606 |