MeSH term | MeSH ID | Detail |
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Coronary Occlusion | D054059 | 4 associated lipids |
14r,15s-epetre is a lipid of Fatty Acyls (FA) class. 14r,15s-epetre is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14r,15s-epetre often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14r,15s-epetre are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
To understand associated biological information of 14r,15s-epetre, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
14r,15s-epetre is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 14r,15s-epetre
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sporková A et al. | Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. | 2017 | Physiol Res | pmid:27782740 |
Li Y et al. | 14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27591243 |
El-Sikhry HE et al. | Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. | 2016 | PLoS ONE | pmid:27494529 |
Sporková A et al. | Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. | 2016 | Am. J. Med. Sci. | pmid:27140711 |
Kandhi S et al. | EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. | 2016 | Am. J. Hypertens. | pmid:26304959 |
Yang L et al. | CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. | 2015 Jan-Mar | Prostaglandins Other Lipid Mediat. | pmid:25686540 |
Kandhi S et al. | EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26498250 |
Li P et al. | Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. | 2015 | Nature | pmid:26201599 |
Jiang JX et al. | EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. | 2015 | PLoS ONE | pmid:26035589 |
Yu G et al. | 14,15-epoxyeicosatrienoic Acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress. | 2015 | Cell. Physiol. Biochem. | pmid:25968975 |
Xu J et al. | Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. | 2015 | Insect Biochem. Mol. Biol. | pmid:25686802 |
Imig JD | Epoxyeicosatrienoic acids, hypertension, and kidney injury. | 2015 | Hypertension | pmid:25583156 |
Chen G et al. | CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. | 2015 | Am. J. Physiol. Endocrinol. Metab. | pmid:25389366 |
Siler DA et al. | Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage. | 2015 | Neurocrit Care | pmid:25231529 |
Wei X et al. | Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. | 2014 | BMC Cancer | pmid:25406731 |
Teder T et al. | Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. | 2014 | J. Lipid Res. | pmid:25293588 |
Su KH et al. | Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. | 2014 | Int. J. Biol. Sci. | pmid:25210497 |
Falck JR et al. | 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. | 2014 | J. Med. Chem. | pmid:25119815 |
Wang X et al. | CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. | 2014 | Mol. Pharmacol. | pmid:24145329 |
Althurwi HN et al. | Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. | 2014 | J. Cardiovasc. Pharmacol. | pmid:24157956 |
Wang L et al. | 14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24931672 |
Amara IE et al. | Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. | 2014 | Toxicol. Lett. | pmid:24472606 |
Diani-Moore S et al. | Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. | 2014 | Drug Metab. Dispos. | pmid:24311719 |
Tse MM et al. | Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. | 2013 May-Jun | Vascul. Pharmacol. | pmid:23466634 |
Oni-Orisan A et al. | Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23000418 |
Chaudhary KR et al. | Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22922020 |
Podolin PL et al. | In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23434473 |
Chen L et al. | Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23247129 |
Gross GJ et al. | Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:22407888 |
Tabet Y et al. | Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23418089 |
Pidkovka N et al. | Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. | 2013 | J. Biol. Chem. | pmid:23283969 |
Nelson JW et al. | Soluble epoxide hydrolase dimerization is required for hydrolase activity. | 2013 | J. Biol. Chem. | pmid:23362272 |
Sander AL et al. | Soluble epoxide hydrolase disruption as therapeutic target for wound healing. | 2013 | J. Surg. Res. | pmid:23122666 |
Cracowski JL et al. | Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. | 2013 | J. Appl. Physiol. | pmid:23172029 |
Gross GJ et al. | Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. | 2013 | J. Mol. Cell. Cardiol. | pmid:23419451 |
Eid S et al. | 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. | 2013 | PLoS ONE | pmid:23936373 |
Samokhvalov V et al. | Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. | 2013 | Cell Death Dis | pmid:24157879 |
Yang T et al. | The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. | 2013 | Lipids Health Dis | pmid:24148690 |
Chadderdon SM et al. | Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22739105 |
Gupta NC et al. | Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22723436 |
Decker M et al. | EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. | 2012 | J. Lipid Res. | pmid:22798687 |
Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
Zhang D et al. | Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. | 2012 | Circ. Res. | pmid:22354938 |
Terashvili M et al. | The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. | 2012 | Neuroscience | pmid:22863680 |
Wang SB et al. | Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. | 2012 | J Asian Nat Prod Res | pmid:23106500 |
Herse F et al. | Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. | 2012 | Circulation | pmid:23155181 |
Li R et al. | Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23041291 |
Ward NC et al. | Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. | 2011 | Clin. Sci. | pmid:21689071 |
Pavlov TS et al. | Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21697242 |
Mitra R et al. | CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). | 2011 | J. Biol. Chem. | pmid:21402692 |
Schebb NH et al. | Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. | 2011 | Anal Bioanal Chem | pmid:21479549 |
Chen Y et al. | 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. | 2011 | Biochemistry | pmid:21469660 |
Bukhari IA et al. | 14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries. | 2011 | J. Pharmacol. Exp. Ther. | pmid:20881018 |
Sridar C et al. | Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. | 2011 | Drug Metab. Dispos. | pmid:21289075 |
Kopf PG et al. | Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. | 2011 | Hypertension | pmid:21199991 |
Skepner JE et al. | Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21040800 |
Shao J et al. | P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. | 2011 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:22038346 |
Zhu P et al. | Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21798825 |
Gauthier KM et al. | Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21753077 |
Farr H and David T | Models of neurovascular coupling via potassium and EET signalling. | 2011 | J. Theor. Biol. | pmid:21781976 |
Senouvo FY et al. | Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21821730 |
Sarkar P et al. | Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. | 2011 | Neuroscience | pmid:21843605 |
Gross GJ et al. | Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20400686 |
Merkel MJ et al. | Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20008276 |
Morin C et al. | 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20008283 |
Yang C et al. | 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601071 |
Imaizumi S et al. | L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. | 2010 | Drug Metab Lett | pmid:20642447 |
Townsley MI et al. | Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. | 2010 | Microcirculation | pmid:20163540 |
Planagumà A et al. | Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. | 2010 | Mucosal Immunol | pmid:20130564 |
Lamb DC et al. | Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. | 2010 | Appl. Environ. Microbiol. | pmid:20097805 |
Behm DJ et al. | Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. | 2009 | J. Pharmacol. Exp. Ther. | pmid:18836067 |
Chen Y et al. | 20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site. | 2009 | J. Pharmacol. Exp. Ther. | pmid:19762546 |
Falck JR et al. | 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. | 2009 | J. Med. Chem. | pmid:19653681 |
Motoki A et al. | Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18835921 |
Terashvili M et al. | Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18492947 |
Smith HE et al. | Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. | 2008 | Pharmacogenet. Genomics | pmid:18769365 |
Snider NT et al. | The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18698000 |
Morin C et al. | CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18757304 |
Morin C et al. | EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17872494 |
Michaelis UR et al. | Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18326754 |
Ghosh S et al. | Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. | 2008 | Basic Clin. Pharmacol. Toxicol. | pmid:18312493 |
Gross GJ et al. | Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441205 |
Cheranov SY et al. | An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. | 2008 | Blood | pmid:18408167 |
Morin C and Rousseau E | Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164130 |
Jiang JG et al. | Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164144 |
Morin C et al. | Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17237191 |
Gross GJ et al. | Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. | 2007 | J. Mol. Cell. Cardiol. | pmid:17217955 |
Chen J et al. | Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. | 2007 | Mol. Cell. Biol. | pmid:17283047 |
Koerner IP et al. | Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. | 2007 | J. Neurosci. | pmid:17460077 |
Yang W et al. | Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17327488 |
Ye D et al. | Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16537788 |
Sacerdoti D et al. | Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16798831 |
Campbell WB et al. | Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16143653 |
Zhang B et al. | Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. | 2006 | J. Biol. Chem. | pmid:16286479 |
Fang X et al. | 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16113065 |
Wang XL et al. | Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. | 2006 | Biochim. Biophys. Acta | pmid:16904368 |
Wei S et al. | Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. | 2006 | Anal. Biochem. | pmid:16480681 |
Spiecker M and Liao JK | Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. | 2005 | Arch. Biochem. Biophys. | pmid:15581597 |
Alvarez DF et al. | Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16051904 |
Dunn LK et al. | Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). | 2005 | Anat Rec A Discov Mol Cell Evol Biol | pmid:15952186 |