MeSH term | MeSH ID | Detail |
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Coronary Occlusion | D054059 | 4 associated lipids |
14r,15s-epetre is a lipid of Fatty Acyls (FA) class. 14r,15s-epetre is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14r,15s-epetre often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14r,15s-epetre are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
To understand associated biological information of 14r,15s-epetre, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
14r,15s-epetre is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 14r,15s-epetre
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Capdevila J et al. | Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. | 1985 | Arch. Biochem. Biophys. | pmid:3933431 |
Zosmer A et al. | Formation and metabolism of 14,15-epoxyeicosatrienoic acid by human reproductive tissues. | 1995 | Biochim. Biophys. Acta | pmid:7548192 |
Fang X et al. | Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells. | 1995 | J. Lipid Res. | pmid:7666001 |
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Daikh BE et al. | Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9. | 1994 | J. Pharmacol. Exp. Ther. | pmid:7996455 |
Staudinger R et al. | Effects of epoxyeicosatrienoic acids on 86Rb uptake in renal epithelial cells. | 1994 | J. Cell. Physiol. | pmid:8021300 |
Ma YH et al. | Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. | 1994 | Am. J. Physiol. | pmid:8067471 |
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Rosolowsky M and Campbell WB | Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. | 1993 | Am. J. Physiol. | pmid:8447448 |
Moffat MP et al. | Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. | 1993 | Am. J. Physiol. | pmid:8476093 |
Alkayed NJ et al. | Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. | 1996 | Stroke | pmid:8623121 |
Capdevila JH et al. | The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. | 1996 | J. Biol. Chem. | pmid:8798438 |
Zeldin DC et al. | CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. | 1996 | Mol. Pharmacol. | pmid:8913342 |
Zou AP et al. | Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. | 1996 | Am. J. Physiol. | pmid:8928844 |
Nithipatikom K et al. | Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. | 1997 | Anal. Biochem. | pmid:9073364 |
Weintraub NL et al. | Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. | 1997 | Circ. Res. | pmid:9242187 |
Wong PY et al. | Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. | 1997 | J Lipid Mediat Cell Signal | pmid:9246605 |
Leffler CW and Fedinec AL | Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. | 1997 | Am. J. Physiol. | pmid:9249508 |
Peri KG et al. | Stimulation of prostaglandin G/H synthase-2 expression by arachidonic acid monoxygenase product, 14,15-epoxyeicosatrienoic acid. | 1997 | FEBS Lett. | pmid:9373167 |
Baron A et al. | Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells. | 1997 | J. Physiol. (Lond.) | pmid:9401962 |
Fang X et al. | Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430380 |
Peri KG et al. | A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514882 |
Gebremedhin D et al. | Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. | 1998 Jul-Aug | J. Vasc. Res. | pmid:9701712 |
Fang X et al. | 14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells. | 1998 | Am. J. Physiol. | pmid:9843811 |
Medhora M and Harder D | Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). | 1998 | Int. J. Mol. Med. | pmid:9850733 |
Rzigalinski BA et al. | Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid. | 1999 | J. Biol. Chem. | pmid:9867827 |
Hutcheson IR et al. | Nitric oxide-independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication. Role of Gap junctions and phospholipase A2. | 1999 Jan 8-22 | Circ. Res. | pmid:9915774 |
Chen JK et al. | Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. | 1999 | J. Biol. Chem. | pmid:9988714 |