14r,15s-epetre

14r,15s-epetre is a lipid of Fatty Acyls (FA) class. 14r,15s-epetre is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14r,15s-epetre often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14r,15s-epetre are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.

Cross Reference

Introduction

To understand associated biological information of 14r,15s-epetre, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 14r,15s-epetre?

14r,15s-epetre is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 14r,15s-epetre

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Brain Ischemia D002545 89 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Hyperemia D006940 25 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Hypertrophy D006984 16 associated lipids
Lung Injury D055370 14 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with 14r,15s-epetre

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 14r,15s-epetre?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 14r,15s-epetre?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 14r,15s-epetre?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 14r,15s-epetre?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 14r,15s-epetre?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 14r,15s-epetre

Download all related citations
Per page 10 20 50 100 | Total 232
Authors Title Published Journal PubMed Link
Rzigalinski BA et al. Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid. 1999 J. Biol. Chem. pmid:9867827
Silverstein DM et al. Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10582656
Chen JK et al. Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. 1999 J. Biol. Chem. pmid:9988714
Gebremedhin D et al. Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. 1998 Jul-Aug J. Vasc. Res. pmid:9701712
Peri KG et al. A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. 1998 Biochem. Biophys. Res. Commun. pmid:9514882
Medhora M and Harder D Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). 1998 Int. J. Mol. Med. pmid:9850733
Fang X et al. 14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells. 1998 Am. J. Physiol. pmid:9843811
Peri KG et al. Stimulation of prostaglandin G/H synthase-2 expression by arachidonic acid monoxygenase product, 14,15-epoxyeicosatrienoic acid. 1997 FEBS Lett. pmid:9373167
Weintraub NL et al. Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. 1997 Circ. Res. pmid:9242187
Wong PY et al. Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. 1997 J Lipid Mediat Cell Signal pmid:9246605
Leffler CW and Fedinec AL Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. 1997 Am. J. Physiol. pmid:9249508
Baron A et al. Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells. 1997 J. Physiol. (Lond.) pmid:9401962
Nithipatikom K et al. Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. 1997 Anal. Biochem. pmid:9073364
Fang X et al. Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430380
Alkayed NJ et al. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. 1996 Stroke pmid:8623121
Zeldin DC et al. CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. 1996 Mol. Pharmacol. pmid:8913342
Zou AP et al. Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. 1996 Am. J. Physiol. pmid:8928844
Capdevila JH et al. The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. 1996 J. Biol. Chem. pmid:8798438
VanRollins M et al. Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo. 1995 Biochim. Biophys. Acta pmid:7786887
Fang X et al. Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells. 1995 J. Lipid Res. pmid:7666001
Shivachar AC et al. Effect of protein kinase C modulators on 14,15-epoxyeicosatrienoic acid incorporation into astroglial phospholipids. 1995 J. Neurochem. pmid:7790878
Zosmer A et al. Formation and metabolism of 14,15-epoxyeicosatrienoic acid by human reproductive tissues. 1995 Biochim. Biophys. Acta pmid:7548192
Zhu Y et al. Identification of arachidonate P-450 metabolites in human platelet phospholipids. 1995 Hypertension pmid:7721444
Ma YH et al. Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. 1994 Am. J. Physiol. pmid:8067471
Daikh BE et al. Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9. 1994 J. Pharmacol. Exp. Ther. pmid:7996455
Staudinger R et al. Effects of epoxyeicosatrienoic acids on 86Rb uptake in renal epithelial cells. 1994 J. Cell. Physiol. pmid:8021300
Imig JD et al. Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. 1994 Am. J. Physiol. pmid:8203587
Moffat MP et al. Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. 1993 Am. J. Physiol. pmid:8476093
Rosolowsky M and Campbell WB Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. 1993 Am. J. Physiol. pmid:8447448
Amruthesh SC et al. Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid. 1992 J. Neurochem. pmid:1729396
Seki K et al. Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. 1992 Biochem. J. pmid:1731754
Malcolm KC and Fitzpatrick FA Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. 1992 J. Biol. Chem. pmid:1400301
Karara A et al. Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. 1992 Biochem. Biophys. Res. Commun. pmid:1540175
Carroll MA et al. Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. 1992 J. Pharmacol. Exp. Ther. pmid:1731035
Bernstrom K et al. Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. 1992 J. Biol. Chem. pmid:1740420
Heizer ML et al. 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. 1991 Stroke pmid:1750047
Pfister SL et al. Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. 1991 Am. J. Physiol. pmid:1887929
Force T et al. Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. 1991 J. Biol. Chem. pmid:1900289
Capdevila JH et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. 1990 J. Biol. Chem. pmid:2358445
Karara A et al. Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. 1990 FEBS Lett. pmid:2384159
Pritchard KA et al. 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. 1990 Biochem. Biophys. Res. Commun. pmid:2310385
Lin WK et al. Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. 1990 Biochem. Biophys. Res. Commun. pmid:2322287
Ellis EF et al. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. 1990 Am. J. Physiol. pmid:2121049
Catella F et al. Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2198572
Henrich WL et al. Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices. 1990 Am. J. Physiol. pmid:2154933
Harris RC et al. Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. 1990 J. Cell. Physiol. pmid:2167900
Karara A et al. Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. 1989 J. Biol. Chem. pmid:2584196
Hammonds TD et al. Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. 1989 Anal. Biochem. pmid:2610347
Snyder GD et al. Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. 1989 Am. J. Physiol. pmid:2563927
Patel L et al. Production of epoxygenase metabolite by human reproductive tissues. 1989 Prostaglandins pmid:2517348