14r,15s-epetre

14r,15s-epetre is a lipid of Fatty Acyls (FA) class. 14r,15s-epetre is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14r,15s-epetre often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14r,15s-epetre are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.

Cross Reference

Introduction

To understand associated biological information of 14r,15s-epetre, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 14r,15s-epetre?

14r,15s-epetre is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 14r,15s-epetre

MeSH term MeSH ID Detail
Diabetic Nephropathies D003928 39 associated lipids
Hyperemia D006940 25 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Brain Ischemia D002545 89 associated lipids
Hypertension D006973 115 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Hypertrophy D006984 16 associated lipids
Insulin Resistance D007333 99 associated lipids
Lung Injury D055370 14 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with 14r,15s-epetre

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 14r,15s-epetre?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 14r,15s-epetre?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 14r,15s-epetre?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 14r,15s-epetre?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 14r,15s-epetre?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 14r,15s-epetre

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Authors Title Published Journal PubMed Link
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Kandhi S et al. EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. 2016 Am. J. Hypertens. pmid:26304959
Sporková A et al. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. 2016 Am. J. Med. Sci. pmid:27140711
Pfister SL et al. Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. 1991 Am. J. Physiol. pmid:1887929
Leffler CW and Fedinec AL Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. 1997 Am. J. Physiol. pmid:9249508
Ma YH et al. Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. 1994 Am. J. Physiol. pmid:8067471
Snyder GD et al. Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. 1989 Am. J. Physiol. pmid:2563927
Imig JD et al. Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. 1994 Am. J. Physiol. pmid:8203587
Fang X et al. 14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells. 1998 Am. J. Physiol. pmid:9843811
Moffat MP et al. Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. 1993 Am. J. Physiol. pmid:8476093
Rosolowsky M and Campbell WB Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. 1993 Am. J. Physiol. pmid:8447448
Schlondorff D et al. Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder. 1987 Am. J. Physiol. pmid:2820243
Weintraub NL et al. Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. 1999 Am. J. Physiol. pmid:10564166
Zou AP et al. Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. 1996 Am. J. Physiol. pmid:8928844
Ellis EF et al. Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. 1990 Am. J. Physiol. pmid:2121049
Henrich WL et al. Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices. 1990 Am. J. Physiol. pmid:2154933
Chadderdon SM et al. Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22739105
Chen G et al. CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:25389366
Ye D et al. Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16537788
Sacerdoti D et al. Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16798831
Campbell WB et al. Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16143653
Motoki A et al. Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18835921
Pratt PF et al. Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11179054
Gross GJ et al. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. 2010 Am. J. Physiol. Heart Circ. Physiol. pmid:20400686
Merkel MJ et al. Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. 2010 Am. J. Physiol. Heart Circ. Physiol. pmid:20008276
Miller AW et al. Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11557540
Zhang Y et al. EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11356595
Rastaldo R et al. Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11356641
Ye D et al. Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15331373
Campbell WB et al. 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11959628
Snyder GD et al. Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12384472
Falck JR et al. Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12388250
Medhora M et al. Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12388259
Fang X et al. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12388281
Nithipatikom K et al. Determination of EETs using microbore liquid chromatography with fluorescence detection. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:10924087
Gross GJ et al. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18441205
Gauthier KM et al. Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15528233
Fang X et al. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16113065
Fang X et al. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:15284062
Li Y et al. 14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27591243
Kandhi S et al. EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26498250
Tabet Y et al. Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23418089
Benoit C et al. EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11290521
Senouvo FY et al. Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. 2011 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21821730
Zhu D et al. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10666118
Alvarez DF et al. Role of EETs in regulation of endothelial permeability in rat lung. 2004 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:14578116
Pavlov TS et al. Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). 2011 Am. J. Physiol. Renal Physiol. pmid:21697242
Gauthier KM et al. Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. 2011 Am. J. Physiol. Renal Physiol. pmid:21753077
Salvail D et al. Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle. 2002 Am. J. Physiol., Cell Physiol. pmid:11832342
Morin C et al. Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17237191
Morin C et al. 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. 2010 Am. J. Respir. Cell Mol. Biol. pmid:20008283
Morin C et al. CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. 2008 Am. J. Respir. Cell Mol. Biol. pmid:18757304
Morin C et al. EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. 2008 Am. J. Respir. Cell Mol. Biol. pmid:17872494
Alvarez DF et al. Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. 2005 Am. J. Respir. Crit. Care Med. pmid:16051904
Schebb NH et al. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. 2011 Anal Bioanal Chem pmid:21479549
Hammonds TD et al. Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. 1989 Anal. Biochem. pmid:2610347
Nithipatikom K et al. Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. 2001 Anal. Biochem. pmid:11319825
Nithipatikom K et al. Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. 1997 Anal. Biochem. pmid:9073364
Wei S et al. Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. 2006 Anal. Biochem. pmid:16480681
Dunn LK et al. Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). 2005 Anat Rec A Discov Mol Cell Evol Biol pmid:15952186
Lamb DC et al. Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. 2010 Appl. Environ. Microbiol. pmid:20097805
Capdevila J et al. Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. 1985 Arch. Biochem. Biophys. pmid:3933431
Oleksiak MF et al. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. 2003 Arch. Biochem. Biophys. pmid:12623071
Capdevila JH et al. NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. 1988 Arch. Biochem. Biophys. pmid:3341770
Spiecker M and Liao JK Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. 2005 Arch. Biochem. Biophys. pmid:15581597
Gupta NC et al. Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22723436
Krötz F et al. Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14715644
Theken KN et al. Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. 2012 Atherosclerosis pmid:22503544
Ghosh S et al. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. 2008 Basic Clin. Pharmacol. Toxicol. pmid:18312493
Peri KG et al. A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. 1998 Biochem. Biophys. Res. Commun. pmid:9514882
Pritchard KA et al. 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. 1990 Biochem. Biophys. Res. Commun. pmid:2310385
Lin WK et al. Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. 1990 Biochem. Biophys. Res. Commun. pmid:2322287
Karara A et al. Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. 1992 Biochem. Biophys. Res. Commun. pmid:1540175
Wang L et al. 14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. 2014 Biochem. Biophys. Res. Commun. pmid:24931672
Xiao ZL et al. Demonstration of endogenous inhibitors for the formation of 14,15-oxido-5,8,11-eicosatrienoic acid from phosphatidylinositol in bovine lung extract. 1988 Biochem. Biophys. Res. Commun. pmid:3421969
Capdevila JH et al. A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). 1987 Biochem. Biophys. Res. Commun. pmid:3619897
Seki K et al. Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. 1992 Biochem. J. pmid:1731754
Wu SN et al. Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells. 2000 Biochem. Pharmacol. pmid:10825470
Chen Y et al. 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. 2011 Biochemistry pmid:21469660