14r,15s-epetre

14r,15s-epetre is a lipid of Fatty Acyls (FA) class. 14r,15s-epetre is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14r,15s-epetre often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14r,15s-epetre are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.

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Introduction

To understand associated biological information of 14r,15s-epetre, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 14r,15s-epetre?

14r,15s-epetre is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 14r,15s-epetre

MeSH term MeSH ID Detail
Diabetic Nephropathies D003928 39 associated lipids
Hyperemia D006940 25 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Brain Ischemia D002545 89 associated lipids
Hypertension D006973 115 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Hypertrophy D006984 16 associated lipids
Insulin Resistance D007333 99 associated lipids
Lung Injury D055370 14 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with 14r,15s-epetre

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 14r,15s-epetre?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 14r,15s-epetre?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 14r,15s-epetre?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 14r,15s-epetre?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 14r,15s-epetre?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 14r,15s-epetre

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Authors Title Published Journal PubMed Link
Sporková A et al. Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. 2017 Physiol Res pmid:27782740
Li Y et al. 14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27591243
El-Sikhry HE et al. Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. 2016 PLoS ONE pmid:27494529
Sporková A et al. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. 2016 Am. J. Med. Sci. pmid:27140711
Kandhi S et al. EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. 2016 Am. J. Hypertens. pmid:26304959
Yang L et al. CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. 2015 Jan-Mar Prostaglandins Other Lipid Mediat. pmid:25686540
Kandhi S et al. EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26498250
Li P et al. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. 2015 Nature pmid:26201599
Jiang JX et al. EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. 2015 PLoS ONE pmid:26035589
Yu G et al. 14,15-epoxyeicosatrienoic Acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress. 2015 Cell. Physiol. Biochem. pmid:25968975
Xu J et al. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. 2015 Insect Biochem. Mol. Biol. pmid:25686802
Imig JD Epoxyeicosatrienoic acids, hypertension, and kidney injury. 2015 Hypertension pmid:25583156
Chen G et al. CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:25389366
Siler DA et al. Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage. 2015 Neurocrit Care pmid:25231529
Wei X et al. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. 2014 BMC Cancer pmid:25406731
Teder T et al. Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. 2014 J. Lipid Res. pmid:25293588
Su KH et al. Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. 2014 Int. J. Biol. Sci. pmid:25210497
Falck JR et al. 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. 2014 J. Med. Chem. pmid:25119815
Wang X et al. CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. 2014 Mol. Pharmacol. pmid:24145329
Althurwi HN et al. Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. 2014 J. Cardiovasc. Pharmacol. pmid:24157956
Wang L et al. 14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. 2014 Biochem. Biophys. Res. Commun. pmid:24931672
Amara IE et al. Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. 2014 Toxicol. Lett. pmid:24472606
Diani-Moore S et al. Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. 2014 Drug Metab. Dispos. pmid:24311719
Tse MM et al. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. 2013 May-Jun Vascul. Pharmacol. pmid:23466634
Oni-Orisan A et al. Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23000418
Chaudhary KR et al. Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:22922020
Podolin PL et al. In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23434473
Chen L et al. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23247129
Gross GJ et al. Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. 2013 J. Cardiovasc. Pharmacol. Ther. pmid:22407888
Tabet Y et al. Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23418089
Pidkovka N et al. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. 2013 J. Biol. Chem. pmid:23283969
Nelson JW et al. Soluble epoxide hydrolase dimerization is required for hydrolase activity. 2013 J. Biol. Chem. pmid:23362272
Sander AL et al. Soluble epoxide hydrolase disruption as therapeutic target for wound healing. 2013 J. Surg. Res. pmid:23122666
Cracowski JL et al. Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. 2013 J. Appl. Physiol. pmid:23172029
Gross GJ et al. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. 2013 J. Mol. Cell. Cardiol. pmid:23419451
Eid S et al. 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. 2013 PLoS ONE pmid:23936373
Samokhvalov V et al. Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. 2013 Cell Death Dis pmid:24157879
Yang T et al. The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. 2013 Lipids Health Dis pmid:24148690
Chadderdon SM et al. Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22739105
Gupta NC et al. Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22723436
Decker M et al. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. 2012 J. Lipid Res. pmid:22798687
Theken KN et al. Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. 2012 Atherosclerosis pmid:22503544
Zhang D et al. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. 2012 Circ. Res. pmid:22354938
Terashvili M et al. The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. 2012 Neuroscience pmid:22863680
Wang SB et al. Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. 2012 J Asian Nat Prod Res pmid:23106500
Herse F et al. Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. 2012 Circulation pmid:23155181
Li R et al. Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. 2012 Prostaglandins Other Lipid Mediat. pmid:23041291
Ward NC et al. Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. 2011 Clin. Sci. pmid:21689071
Pavlov TS et al. Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). 2011 Am. J. Physiol. Renal Physiol. pmid:21697242
Mitra R et al. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). 2011 J. Biol. Chem. pmid:21402692
Schebb NH et al. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. 2011 Anal Bioanal Chem pmid:21479549
Chen Y et al. 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. 2011 Biochemistry pmid:21469660
Bukhari IA et al. 14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries. 2011 J. Pharmacol. Exp. Ther. pmid:20881018
Sridar C et al. Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. 2011 Drug Metab. Dispos. pmid:21289075
Kopf PG et al. Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. 2011 Hypertension pmid:21199991
Skepner JE et al. Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes. 2011 Prostaglandins Other Lipid Mediat. pmid:21040800
Shao J et al. P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. 2011 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:22038346
Zhu P et al. Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21798825
Gauthier KM et al. Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. 2011 Am. J. Physiol. Renal Physiol. pmid:21753077
Farr H and David T Models of neurovascular coupling via potassium and EET signalling. 2011 J. Theor. Biol. pmid:21781976
Senouvo FY et al. Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. 2011 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21821730
Sarkar P et al. Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. 2011 Neuroscience pmid:21843605
Gross GJ et al. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. 2010 Am. J. Physiol. Heart Circ. Physiol. pmid:20400686
Merkel MJ et al. Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. 2010 Am. J. Physiol. Heart Circ. Physiol. pmid:20008276
Morin C et al. 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. 2010 Am. J. Respir. Cell Mol. Biol. pmid:20008283
Yang C et al. 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. 2010 Prostaglandins Other Lipid Mediat. pmid:20601071
Imaizumi S et al. L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. 2010 Drug Metab Lett pmid:20642447
Townsley MI et al. Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. 2010 Microcirculation pmid:20163540
Planagumà A et al. Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. 2010 Mucosal Immunol pmid:20130564
Lamb DC et al. Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. 2010 Appl. Environ. Microbiol. pmid:20097805
Behm DJ et al. Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. 2009 J. Pharmacol. Exp. Ther. pmid:18836067
Chen Y et al. 20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site. 2009 J. Pharmacol. Exp. Ther. pmid:19762546
Falck JR et al. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. 2009 J. Med. Chem. pmid:19653681
Motoki A et al. Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18835921
Terashvili M et al. Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. 2008 J. Pharmacol. Exp. Ther. pmid:18492947
Smith HE et al. Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. 2008 Pharmacogenet. Genomics pmid:18769365
Snider NT et al. The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. 2008 J. Pharmacol. Exp. Ther. pmid:18698000
Morin C et al. CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. 2008 Am. J. Respir. Cell Mol. Biol. pmid:18757304
Morin C et al. EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. 2008 Am. J. Respir. Cell Mol. Biol. pmid:17872494
Michaelis UR et al. Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. 2008 Invest. Ophthalmol. Vis. Sci. pmid:18326754
Ghosh S et al. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. 2008 Basic Clin. Pharmacol. Toxicol. pmid:18312493
Gross GJ et al. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18441205
Cheranov SY et al. An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. 2008 Blood pmid:18408167
Morin C and Rousseau E Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. 2007 Prostaglandins Other Lipid Mediat. pmid:17164130
Jiang JG et al. Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. 2007 Prostaglandins Other Lipid Mediat. pmid:17164144
Morin C et al. Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. 2007 Am. J. Respir. Cell Mol. Biol. pmid:17237191
Gross GJ et al. Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. 2007 J. Mol. Cell. Cardiol. pmid:17217955
Chen J et al. Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. 2007 Mol. Cell. Biol. pmid:17283047
Koerner IP et al. Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. 2007 J. Neurosci. pmid:17460077
Yang W et al. Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. 2007 J. Pharmacol. Exp. Ther. pmid:17327488
Ye D et al. Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16537788
Sacerdoti D et al. Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16798831
Campbell WB et al. Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16143653
Zhang B et al. Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. 2006 J. Biol. Chem. pmid:16286479
Fang X et al. 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16113065
Wang XL et al. Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. 2006 Biochim. Biophys. Acta pmid:16904368
Wei S et al. Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. 2006 Anal. Biochem. pmid:16480681
Spiecker M and Liao JK Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. 2005 Arch. Biochem. Biophys. pmid:15581597
Alvarez DF et al. Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. 2005 Am. J. Respir. Crit. Care Med. pmid:16051904
Dunn LK et al. Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). 2005 Anat Rec A Discov Mol Cell Evol Biol pmid:15952186