14r,15s-epetre

14r,15s-epetre is a lipid of Fatty Acyls (FA) class. 14r,15s-epetre is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14r,15s-epetre often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14r,15s-epetre are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.

Cross Reference

Introduction

To understand associated biological information of 14r,15s-epetre, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 14r,15s-epetre?

14r,15s-epetre is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 14r,15s-epetre

MeSH term MeSH ID Detail
Diabetic Nephropathies D003928 39 associated lipids
Hyperemia D006940 25 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Brain Ischemia D002545 89 associated lipids
Hypertension D006973 115 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Hypertrophy D006984 16 associated lipids
Insulin Resistance D007333 99 associated lipids
Lung Injury D055370 14 associated lipids
Per page 10 20 | Total 11

PubChem Associated disorders and diseases

What pathways are associated with 14r,15s-epetre

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 14r,15s-epetre?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 14r,15s-epetre?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 14r,15s-epetre?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 14r,15s-epetre?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 14r,15s-epetre?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 14r,15s-epetre

Download all related citations
Per page 10 20 50 100 | Total 232
Authors Title Published Journal PubMed Link
Sporková A et al. Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. 2017 Physiol Res pmid:27782740
Li Y et al. 14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27591243
El-Sikhry HE et al. Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. 2016 PLoS ONE pmid:27494529
Sporková A et al. Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. 2016 Am. J. Med. Sci. pmid:27140711
Kandhi S et al. EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. 2016 Am. J. Hypertens. pmid:26304959
Yang L et al. CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. 2015 Jan-Mar Prostaglandins Other Lipid Mediat. pmid:25686540
Kandhi S et al. EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26498250
Li P et al. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. 2015 Nature pmid:26201599
Jiang JX et al. EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. 2015 PLoS ONE pmid:26035589
Yu G et al. 14,15-epoxyeicosatrienoic Acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress. 2015 Cell. Physiol. Biochem. pmid:25968975
Xu J et al. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. 2015 Insect Biochem. Mol. Biol. pmid:25686802
Imig JD Epoxyeicosatrienoic acids, hypertension, and kidney injury. 2015 Hypertension pmid:25583156
Chen G et al. CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:25389366
Siler DA et al. Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage. 2015 Neurocrit Care pmid:25231529
Wei X et al. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. 2014 BMC Cancer pmid:25406731
Teder T et al. Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. 2014 J. Lipid Res. pmid:25293588
Su KH et al. Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. 2014 Int. J. Biol. Sci. pmid:25210497
Falck JR et al. 14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. 2014 J. Med. Chem. pmid:25119815
Wang X et al. CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. 2014 Mol. Pharmacol. pmid:24145329
Althurwi HN et al. Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. 2014 J. Cardiovasc. Pharmacol. pmid:24157956
Wang L et al. 14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. 2014 Biochem. Biophys. Res. Commun. pmid:24931672
Amara IE et al. Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. 2014 Toxicol. Lett. pmid:24472606
Diani-Moore S et al. Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. 2014 Drug Metab. Dispos. pmid:24311719
Tse MM et al. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. 2013 May-Jun Vascul. Pharmacol. pmid:23466634
Oni-Orisan A et al. Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23000418
Chaudhary KR et al. Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:22922020
Podolin PL et al. In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23434473
Chen L et al. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. 2013 Jul-Aug Prostaglandins Other Lipid Mediat. pmid:23247129
Gross GJ et al. Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. 2013 J. Cardiovasc. Pharmacol. Ther. pmid:22407888
Tabet Y et al. Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23418089
Pidkovka N et al. Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. 2013 J. Biol. Chem. pmid:23283969
Nelson JW et al. Soluble epoxide hydrolase dimerization is required for hydrolase activity. 2013 J. Biol. Chem. pmid:23362272
Sander AL et al. Soluble epoxide hydrolase disruption as therapeutic target for wound healing. 2013 J. Surg. Res. pmid:23122666
Cracowski JL et al. Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. 2013 J. Appl. Physiol. pmid:23172029
Gross GJ et al. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. 2013 J. Mol. Cell. Cardiol. pmid:23419451
Eid S et al. 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. 2013 PLoS ONE pmid:23936373
Samokhvalov V et al. Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. 2013 Cell Death Dis pmid:24157879
Yang T et al. The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. 2013 Lipids Health Dis pmid:24148690
Chadderdon SM et al. Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22739105
Gupta NC et al. Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. 2012 Arterioscler. Thromb. Vasc. Biol. pmid:22723436
Decker M et al. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. 2012 J. Lipid Res. pmid:22798687
Theken KN et al. Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. 2012 Atherosclerosis pmid:22503544
Zhang D et al. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. 2012 Circ. Res. pmid:22354938
Terashvili M et al. The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. 2012 Neuroscience pmid:22863680
Wang SB et al. Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. 2012 J Asian Nat Prod Res pmid:23106500
Herse F et al. Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. 2012 Circulation pmid:23155181
Li R et al. Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. 2012 Prostaglandins Other Lipid Mediat. pmid:23041291
Shao J et al. P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. 2011 J. Huazhong Univ. Sci. Technol. Med. Sci. pmid:22038346
Zhu P et al. Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:21798825
Sarkar P et al. Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. 2011 Neuroscience pmid:21843605