There are no associated biomedical information in the current reference collection.

Current reference collection contains 481 references associated with 5,6-eet in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 5,6-eet

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 5,6-eet

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Hypertension D006973 115 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Total 3

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 5,6-eet

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Authors Title Published Journal PubMed Link
Kandhi S et al. EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. 2016 Am. J. Hypertens. pmid:26304959
Diani-Moore S et al. Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. 2014 Drug Metab. Dispos. pmid:24311719
Frömel T et al. Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. 2013 Basic Res. Cardiol. pmid:23224081
Cracowski JL et al. Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. 2013 J. Appl. Physiol. pmid:23172029
Gamliel-Lazarovich A et al. Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid. 2012 Atherosclerosis pmid:22365750
Herse F et al. Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. 2012 Circulation pmid:23155181
Sisignano M et al. 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. 2012 J. Neurosci. pmid:22553041
Snider NT et al. A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. 2009 Mol. Pharmacol. pmid:19171674
Loot AE et al. Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation. 2008 Cardiovasc. Res. pmid:18682435
Li Y et al. Arachidonic acid metabolites inhibit the stimulatory effect of angiotensin II in renal proximal tubules. 2008 Hypertens. Res. pmid:19139605
Sipe WE et al. Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18325985
Fernandes J et al. IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. 2008 J. Cell Biol. pmid:18378772
Vriens J et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. 2007 J. Biol. Chem. pmid:17341586
Moreland KT et al. Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries. 2007 J. Pharmacol. Exp. Ther. pmid:17267581
Snider NT et al. Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. 2007 J. Pharmacol. Exp. Ther. pmid:17272674
Muldowney JA et al. Acute tissue-type plasminogen activator release in human microvascular endothelial cells: the roles of Galphaq, PLC-beta, IP3 and 5,6-epoxyeicosatrienoic acid. 2007 Thromb. Haemost. pmid:17264956
Metea MR and Newman EA Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. 2006 J. Neurosci. pmid:16540563
Sacerdoti D et al. Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16798831
Ben-Amor N et al. A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets. 2006 J. Physiol. (Lond.) pmid:16308346
Wei S et al. Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. 2006 Anal. Biochem. pmid:16480681