Tse MM et al. |
Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. |
2013 May-Jun |
Vascul. Pharmacol. |
pmid:23466634
|
Medhora M et al. |
Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. |
2001 |
Trends Cardiovasc. Med. |
pmid:11413051
|
Amara IE et al. |
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. |
2014 |
Toxicol. Lett. |
pmid:24472606
|
Heizer ML et al. |
14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. |
1991 |
Stroke |
pmid:1750047
|
Alkayed NJ et al. |
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. |
1996 |
Stroke |
pmid:8623121
|
Zhang C and Harder DR |
Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. |
2002 |
Stroke |
pmid:12468797
|
Node K et al. |
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. |
1999 |
Science |
pmid:10455056
|
Morin C and Rousseau E |
Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17164130
|
Jiang JG et al. |
Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. |
2007 |
Prostaglandins Other Lipid Mediat. |
pmid:17164144
|
Oni-Orisan A et al. |
Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:23000418
|
Chaudhary KR et al. |
Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:22922020
|
Podolin PL et al. |
In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:23434473
|
Yang L et al. |
CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. |
2015 Jan-Mar |
Prostaglandins Other Lipid Mediat. |
pmid:25686540
|
Chen L et al. |
Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:23247129
|
Yang C et al. |
14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. |
2010 |
Prostaglandins Other Lipid Mediat. |
pmid:20601071
|
Li R et al. |
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. |
2012 |
Prostaglandins Other Lipid Mediat. |
pmid:23041291
|
Skepner JE et al. |
Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes. |
2011 |
Prostaglandins Other Lipid Mediat. |
pmid:21040800
|
Fang X et al. |
Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells. |
2003 |
Prostaglandins Other Lipid Mediat. |
pmid:12749592
|
Wong PY et al. |
Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes. |
2000 |
Prostaglandins Other Lipid Mediat. |
pmid:11060896
|
Silverstein DM et al. |
Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. |
1999 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:10582656
|
Fang X et al. |
Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells. |
1997 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9430380
|
Patel L et al. |
Production of epoxygenase metabolite by human reproductive tissues. |
1989 |
Prostaglandins |
pmid:2517348
|
Ballou LR et al. |
Formation of cis-14,15-oxido-5,8,11-icosatrienoic acid from phosphatidylinositol in human platelets. |
1987 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:3118357
|
Catella F et al. |
Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. |
1990 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:2198572
|
El-Sikhry HE et al. |
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. |
2016 |
PLoS ONE |
pmid:27494529
|
Jiang JX et al. |
EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. |
2015 |
PLoS ONE |
pmid:26035589
|
Eid S et al. |
20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. |
2013 |
PLoS ONE |
pmid:23936373
|
Sporková A et al. |
Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. |
2017 |
Physiol Res |
pmid:27782740
|
Gauthier KM et al. |
14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. |
2004 |
Pharmacol. Res. |
pmid:15026029
|
Smith HE et al. |
Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease. |
2008 |
Pharmacogenet. Genomics |
pmid:18769365
|
Tréluyer JM et al. |
Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. |
2000 |
Pediatr. Res. |
pmid:10813596
|
Terashvili M et al. |
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. |
2012 |
Neuroscience |
pmid:22863680
|
Sarkar P et al. |
Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. |
2011 |
Neuroscience |
pmid:21843605
|
Siler DA et al. |
Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage. |
2015 |
Neurocrit Care |
pmid:25231529
|
Li P et al. |
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. |
2015 |
Nature |
pmid:26201599
|
Planagumà A et al. |
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. |
2010 |
Mucosal Immunol |
pmid:20130564
|
Zeldin DC et al. |
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. |
1996 |
Mol. Pharmacol. |
pmid:8913342
|
Wang X et al. |
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. |
2014 |
Mol. Pharmacol. |
pmid:24145329
|
Yu Z et al. |
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. |
2000 |
Mol. Pharmacol. |
pmid:10779386
|
Chen J et al. |
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. |
2007 |
Mol. Cell. Biol. |
pmid:17283047
|
Townsley MI et al. |
Impact of epoxyeicosatrienoic acids in lung ischemia-reperfusion injury. |
2010 |
Microcirculation |
pmid:20163540
|
Yang T et al. |
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. |
2013 |
Lipids Health Dis |
pmid:24148690
|
Wang D et al. |
Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles. |
2003 |
Kidney Int. |
pmid:12753306
|
Huang S et al. |
Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. |
1999 |
Kidney Int. |
pmid:10231436
|
Gebremedhin D et al. |
Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. |
1998 Jul-Aug |
J. Vasc. Res. |
pmid:9701712
|
Farr H and David T |
Models of neurovascular coupling via potassium and EET signalling. |
2011 |
J. Theor. Biol. |
pmid:21781976
|
Sander AL et al. |
Soluble epoxide hydrolase disruption as therapeutic target for wound healing. |
2013 |
J. Surg. Res. |
pmid:23122666
|
Lee HC et al. |
Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. |
1999 |
J. Physiol. (Lond.) |
pmid:10432346
|
Baron A et al. |
Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells. |
1997 |
J. Physiol. (Lond.) |
pmid:9401962
|
Bukhari IA et al. |
14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries. |
2011 |
J. Pharmacol. Exp. Ther. |
pmid:20881018
|
Terashvili M et al. |
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18492947
|
Daikh BE et al. |
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9. |
1994 |
J. Pharmacol. Exp. Ther. |
pmid:7996455
|
Behm DJ et al. |
Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:18836067
|
Snider NT et al. |
The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. |
2008 |
J. Pharmacol. Exp. Ther. |
pmid:18698000
|
Chen Y et al. |
20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site. |
2009 |
J. Pharmacol. Exp. Ther. |
pmid:19762546
|
Yang W et al. |
Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. |
2007 |
J. Pharmacol. Exp. Ther. |
pmid:17327488
|
Carroll MA et al. |
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. |
1992 |
J. Pharmacol. Exp. Ther. |
pmid:1731035
|
Fang X et al. |
Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. |
2005 |
J. Pharmacol. Exp. Ther. |
pmid:15798002
|
Koerner IP et al. |
Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. |
2007 |
J. Neurosci. |
pmid:17460077
|
Amruthesh SC et al. |
Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid. |
1992 |
J. Neurochem. |
pmid:1729396
|
Shivachar AC et al. |
Effect of protein kinase C modulators on 14,15-epoxyeicosatrienoic acid incorporation into astroglial phospholipids. |
1995 |
J. Neurochem. |
pmid:7790878
|
Gross GJ et al. |
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. |
2007 |
J. Mol. Cell. Cardiol. |
pmid:17217955
|
Gross GJ et al. |
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. |
2013 |
J. Mol. Cell. Cardiol. |
pmid:23419451
|
Falck JR et al. |
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. |
2009 |
J. Med. Chem. |
pmid:19653681
|
Falck JR et al. |
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. |
2014 |
J. Med. Chem. |
pmid:25119815
|
Fang X et al. |
Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells. |
1995 |
J. Lipid Res. |
pmid:7666001
|
Decker M et al. |
EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. |
2012 |
J. Lipid Res. |
pmid:22798687
|
Teder T et al. |
Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. |
2014 |
J. Lipid Res. |
pmid:25293588
|
Imig JD et al. |
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. |
2001 |
J. Hypertens. |
pmid:11393683
|
Shao J et al. |
P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. |
2011 |
J. Huazhong Univ. Sci. Technol. Med. Sci. |
pmid:22038346
|
Zhu P et al. |
Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. |
2011 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:21798825
|
Staudinger R et al. |
Effects of epoxyeicosatrienoic acids on 86Rb uptake in renal epithelial cells. |
1994 |
J. Cell. Physiol. |
pmid:8021300
|
Harris RC et al. |
Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. |
1990 |
J. Cell. Physiol. |
pmid:2167900
|
Gross GJ et al. |
Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. |
2013 |
J. Cardiovasc. Pharmacol. Ther. |
pmid:22407888
|
Althurwi HN et al. |
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. |
2014 |
J. Cardiovasc. Pharmacol. |
pmid:24157956
|
Malcolm KC and Fitzpatrick FA |
Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. |
1992 |
J. Biol. Chem. |
pmid:1400301
|
Karara A et al. |
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. |
1989 |
J. Biol. Chem. |
pmid:2584196
|
Mitra R et al. |
CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). |
2011 |
J. Biol. Chem. |
pmid:21402692
|
Capdevila JH et al. |
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. |
1990 |
J. Biol. Chem. |
pmid:2358445
|
Rzigalinski BA et al. |
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid. |
1999 |
J. Biol. Chem. |
pmid:9867827
|
Pidkovka N et al. |
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. |
2013 |
J. Biol. Chem. |
pmid:23283969
|
Nelson JW et al. |
Soluble epoxide hydrolase dimerization is required for hydrolase activity. |
2013 |
J. Biol. Chem. |
pmid:23362272
|
McGee J and Fitzpatrick F |
Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. |
1985 |
J. Biol. Chem. |
pmid:2995393
|
Fang X et al. |
Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. |
2001 |
J. Biol. Chem. |
pmid:11278979
|
Fitzpatrick FA et al. |
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. |
1986 |
J. Biol. Chem. |
pmid:3095326
|
Force T et al. |
Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. |
1991 |
J. Biol. Chem. |
pmid:1900289
|
Node K et al. |
Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. |
2001 |
J. Biol. Chem. |
pmid:11279071
|
Ladd PA et al. |
Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. |
2003 |
J. Biol. Chem. |
pmid:12840027
|
Chen JK et al. |
Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. |
2000 |
J. Biol. Chem. |
pmid:10788500
|
Bernstrom K et al. |
Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. |
1992 |
J. Biol. Chem. |
pmid:1740420
|
Zhang B et al. |
Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. |
2006 |
J. Biol. Chem. |
pmid:16286479
|
Chen JK et al. |
Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. |
1999 |
J. Biol. Chem. |
pmid:9988714
|
Capdevila JH et al. |
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. |
1996 |
J. Biol. Chem. |
pmid:8798438
|
Cracowski JL et al. |
Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. |
2013 |
J. Appl. Physiol. |
pmid:23172029
|
Miyazono M et al. |
Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. |
2003 |
J. Am. Soc. Nephrol. |
pmid:12819236
|
Wong PY et al. |
Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. |
1997 |
J Lipid Mediat Cell Signal |
pmid:9246605
|
Wang SB et al. |
Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. |
2012 |
J Asian Nat Prod Res |
pmid:23106500
|
Michaelis UR et al. |
Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. |
2008 |
Invest. Ophthalmol. Vis. Sci. |
pmid:18326754
|
Medhora M and Harder D |
Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). |
1998 |
Int. J. Mol. Med. |
pmid:9850733
|
Su KH et al. |
Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. |
2014 |
Int. J. Biol. Sci. |
pmid:25210497
|