| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Occlusion | D054059 | 4 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Prostaglandins Other Lipid Mediat. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Hypertension (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Hypertension (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pratt PF et al. | Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179054 |
| Miller AW et al. | Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11557540 |
| Fisslthaler B et al. | Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. | 2001 | Hypertension | pmid:11751730 |
| Fang X et al. | Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. | 2001 | J. Biol. Chem. | pmid:11278979 |
| Zhang Y et al. | EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356595 |
| Rastaldo R et al. | Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356641 |
| Benoit C et al. | EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11290521 |
| Node K et al. | Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. | 2001 | J. Biol. Chem. | pmid:11279071 |
| Salvail D et al. | Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11832342 |
| Campbell WB et al. | 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11959628 |
| Gauthier KM et al. | 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. | 2002 | Circ. Res. | pmid:12016270 |
| Snyder GD et al. | Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12384472 |
| Fang X et al. | Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388281 |
| Zhang C and Harder DR | Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. | 2002 | Stroke | pmid:12468797 |
| Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
| Falck JR et al. | Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388250 |
| Medhora M et al. | Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388259 |
| Oleksiak MF et al. | Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. | 2003 | Arch. Biochem. Biophys. | pmid:12623071 |
| Miyazono M et al. | Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. | 2003 | J. Am. Soc. Nephrol. | pmid:12819236 |
| Gauthier KM et al. | 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. | 2003 | Hypertension | pmid:12953017 |
| Fang X et al. | Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:12749592 |
| Wang D et al. | Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles. | 2003 | Kidney Int. | pmid:12753306 |
| Ladd PA et al. | Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. | 2003 | J. Biol. Chem. | pmid:12840027 |
| Gauthier KM et al. | 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. | 2004 | Pharmacol. Res. | pmid:15026029 |
| Alvarez DF et al. | Role of EETs in regulation of endothelial permeability in rat lung. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14578116 |
| Fang X et al. | Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15284062 |
| Krötz F et al. | Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14715644 |
| Ye D et al. | Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15331373 |
| Fang X et al. | Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15798002 |
| Spiecker M and Liao JK | Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. | 2005 | Arch. Biochem. Biophys. | pmid:15581597 |
| Gauthier KM et al. | Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15528233 |
| Alvarez DF et al. | Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16051904 |
| Gauthier KM et al. | 14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries. | 2005 | Hypertension | pmid:15699460 |
| Dunn LK et al. | Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). | 2005 | Anat Rec A Discov Mol Cell Evol Biol | pmid:15952186 |
| Jiang JG et al. | Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors. | 2005 | Cancer Res. | pmid:15930289 |
| Ye D et al. | Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16537788 |
| Sacerdoti D et al. | Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16798831 |
| Campbell WB et al. | Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16143653 |
| Zhang B et al. | Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. | 2006 | J. Biol. Chem. | pmid:16286479 |
| Fang X et al. | 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16113065 |
| Wang XL et al. | Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. | 2006 | Biochim. Biophys. Acta | pmid:16904368 |
| Wei S et al. | Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. | 2006 | Anal. Biochem. | pmid:16480681 |
| Morin C and Rousseau E | Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164130 |
| Jiang JG et al. | Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164144 |
| Morin C et al. | Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17237191 |
| Gross GJ et al. | Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. | 2007 | J. Mol. Cell. Cardiol. | pmid:17217955 |
| Chen J et al. | Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. | 2007 | Mol. Cell. Biol. | pmid:17283047 |
| Koerner IP et al. | Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. | 2007 | J. Neurosci. | pmid:17460077 |
| Yang W et al. | Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17327488 |
| Motoki A et al. | Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18835921 |