| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Coronary Occlusion | D054059 | 4 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Prostaglandins Other Lipid Mediat. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- J. Lipid Res. (1)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Hypertension (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li Y et al. | 14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27591243 |
| Kandhi S et al. | EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26498250 |
| Tabet Y et al. | Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23418089 |
| Benoit C et al. | EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11290521 |
| Senouvo FY et al. | Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21821730 |
| Zhu D et al. | Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666118 |
| Alvarez DF et al. | Role of EETs in regulation of endothelial permeability in rat lung. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14578116 |
| Pavlov TS et al. | Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21697242 |
| Gauthier KM et al. | Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21753077 |
| Salvail D et al. | Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11832342 |
| Morin C et al. | Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17237191 |
| Morin C et al. | 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20008283 |
| Morin C et al. | CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18757304 |
| Morin C et al. | EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17872494 |
| Alvarez DF et al. | Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16051904 |
| Schebb NH et al. | Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. | 2011 | Anal Bioanal Chem | pmid:21479549 |
| Hammonds TD et al. | Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. | 1989 | Anal. Biochem. | pmid:2610347 |
| Nithipatikom K et al. | Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | 2001 | Anal. Biochem. | pmid:11319825 |
| Nithipatikom K et al. | Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. | 1997 | Anal. Biochem. | pmid:9073364 |
| Wei S et al. | Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. | 2006 | Anal. Biochem. | pmid:16480681 |