| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Coronary Occlusion | D054059 | 4 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Prostaglandins Other Lipid Mediat. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Hypertension (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Hypertension (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ye D et al. | Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16537788 |
| Sacerdoti D et al. | Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16798831 |
| Wang XL et al. | Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. | 2006 | Biochim. Biophys. Acta | pmid:16904368 |
| Morin C and Rousseau E | Effects of 5-oxo-ETE and 14,15-EET on reactivity and Ca2+ sensitivity in guinea pig bronchi. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164130 |
| Jiang JG et al. | Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17164144 |
| Gross GJ et al. | Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts. | 2007 | J. Mol. Cell. Cardiol. | pmid:17217955 |
| Morin C et al. | Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17237191 |
| Chen J et al. | Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. | 2007 | Mol. Cell. Biol. | pmid:17283047 |
| Amruthesh SC et al. | Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid. | 1992 | J. Neurochem. | pmid:1729396 |
| Carroll MA et al. | Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites. | 1992 | J. Pharmacol. Exp. Ther. | pmid:1731035 |
| Seki K et al. | Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. | 1992 | Biochem. J. | pmid:1731754 |
| Yang W et al. | Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17327488 |
| Bernstrom K et al. | Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. | 1992 | J. Biol. Chem. | pmid:1740420 |
| Koerner IP et al. | Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury. | 2007 | J. Neurosci. | pmid:17460077 |
| Heizer ML et al. | 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. | 1991 | Stroke | pmid:1750047 |
| Morin C et al. | EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17872494 |
| Ghosh S et al. | Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. | 2008 | Basic Clin. Pharmacol. Toxicol. | pmid:18312493 |
| Michaelis UR et al. | Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18326754 |
| Cheranov SY et al. | An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis. | 2008 | Blood | pmid:18408167 |
| Gross GJ et al. | Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441205 |