| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Coronary Occlusion | D054059 | 4 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Prostaglandins Other Lipid Mediat. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Hypertension (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Hypertension (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Malcolm KC and Fitzpatrick FA | Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. | 1992 | J. Biol. Chem. | pmid:1400301 |
| Karara A et al. | Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. | 1989 | J. Biol. Chem. | pmid:2584196 |
| Mitra R et al. | CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). | 2011 | J. Biol. Chem. | pmid:21402692 |
| Capdevila JH et al. | Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. | 1990 | J. Biol. Chem. | pmid:2358445 |
| McGee J and Fitzpatrick F | Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. | 1985 | J. Biol. Chem. | pmid:2995393 |
| Fang X et al. | Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. | 2001 | J. Biol. Chem. | pmid:11278979 |
| Fitzpatrick FA et al. | Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. | 1986 | J. Biol. Chem. | pmid:3095326 |
| Force T et al. | Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. | 1991 | J. Biol. Chem. | pmid:1900289 |
| Node K et al. | Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. | 2001 | J. Biol. Chem. | pmid:11279071 |
| Chen JK et al. | Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. | 2000 | J. Biol. Chem. | pmid:10788500 |
| Bernstrom K et al. | Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids. | 1992 | J. Biol. Chem. | pmid:1740420 |
| Zhang B et al. | Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. | 2006 | J. Biol. Chem. | pmid:16286479 |
| Chen JK et al. | Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. | 1999 | J. Biol. Chem. | pmid:9988714 |
| Cracowski JL et al. | Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. | 2013 | J. Appl. Physiol. | pmid:23172029 |
| Miyazono M et al. | Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. | 2003 | J. Am. Soc. Nephrol. | pmid:12819236 |
| Wong PY et al. | Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. | 1997 | J Lipid Mediat Cell Signal | pmid:9246605 |
| Wang SB et al. | Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. | 2012 | J Asian Nat Prod Res | pmid:23106500 |
| Michaelis UR et al. | Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. | 2008 | Invest. Ophthalmol. Vis. Sci. | pmid:18326754 |
| Medhora M and Harder D | Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). | 1998 | Int. J. Mol. Med. | pmid:9850733 |
| Su KH et al. | Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. | 2014 | Int. J. Biol. Sci. | pmid:25210497 |