MeSH term | MeSH ID | Detail |
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Hypertension | D006973 | 115 associated lipids |
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Huang S et al. | Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. | 1999 | Kidney Int. | pmid:10231436 |
Lee HC et al. | Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. | 1999 | J. Physiol. (Lond.) | pmid:10432346 |
Node K et al. | Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. | 1999 | Science | pmid:10455056 |
Weintraub NL et al. | Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. | 1999 | Am. J. Physiol. | pmid:10564166 |
Silverstein DM et al. | Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582656 |
Fang X et al. | Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells. | 1999 | Hypertension | pmid:10601125 |
Zhu D et al. | Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666118 |
Yu Z et al. | Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. | 2000 | Mol. Pharmacol. | pmid:10779386 |
Chen JK et al. | Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. | 2000 | J. Biol. Chem. | pmid:10788500 |
Tréluyer JM et al. | Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. | 2000 | Pediatr. Res. | pmid:10813596 |
Wu SN et al. | Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells. | 2000 | Biochem. Pharmacol. | pmid:10825470 |
Nithipatikom K et al. | Determination of EETs using microbore liquid chromatography with fluorescence detection. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924087 |
Wong PY et al. | Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060896 |
Yu Z et al. | Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. | 2000 | Circ. Res. | pmid:11090543 |
Pratt PF et al. | Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179054 |
Fang X et al. | Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. | 2001 | J. Biol. Chem. | pmid:11278979 |
Node K et al. | Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. | 2001 | J. Biol. Chem. | pmid:11279071 |
Benoit C et al. | EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11290521 |
Nithipatikom K et al. | Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | 2001 | Anal. Biochem. | pmid:11319825 |