MeSH term | MeSH ID | Detail |
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Coronary Occlusion | D054059 | 4 associated lipids |
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rzigalinski BA et al. | Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid. | 1999 | J. Biol. Chem. | pmid:9867827 |
Lee HC et al. | Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. | 1999 | J. Physiol. (Lond.) | pmid:10432346 |
Node K et al. | Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. | 1999 | Science | pmid:10455056 |
Silverstein DM et al. | Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582656 |
Weintraub NL et al. | Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. | 1999 | Am. J. Physiol. | pmid:10564166 |
Huang S et al. | Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. | 1999 | Kidney Int. | pmid:10231436 |
Chen JK et al. | Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. | 1999 | J. Biol. Chem. | pmid:9988714 |
Hutcheson IR et al. | Nitric oxide-independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication. Role of Gap junctions and phospholipase A2. | 1999 Jan 8-22 | Circ. Res. | pmid:9915774 |
Nithipatikom K et al. | Determination of EETs using microbore liquid chromatography with fluorescence detection. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924087 |
Zhu D et al. | Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666118 |
Wu SN et al. | Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells. | 2000 | Biochem. Pharmacol. | pmid:10825470 |
Yu Z et al. | Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. | 2000 | Mol. Pharmacol. | pmid:10779386 |
Chen JK et al. | Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. | 2000 | J. Biol. Chem. | pmid:10788500 |
Tréluyer JM et al. | Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. | 2000 | Pediatr. Res. | pmid:10813596 |
Yu Z et al. | Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. | 2000 | Circ. Res. | pmid:11090543 |
Wong PY et al. | Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060896 |
Miller AW et al. | Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11557540 |
Fisslthaler B et al. | Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. | 2001 | Hypertension | pmid:11751730 |
Zhang Y et al. | EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356595 |
Rastaldo R et al. | Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356641 |