MeSH term | MeSH ID | Detail |
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Lung Injury | D055370 | 14 associated lipids |
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ye D et al. | Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16537788 |
Sacerdoti D et al. | Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16798831 |
Campbell WB et al. | Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16143653 |
Pratt PF et al. | Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179054 |
Zhang Y et al. | EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356595 |
Rastaldo R et al. | Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356641 |
Ye D et al. | Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15331373 |
Nithipatikom K et al. | Determination of EETs using microbore liquid chromatography with fluorescence detection. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924087 |
Gauthier KM et al. | Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15528233 |
Fang X et al. | 14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16113065 |
Li Y et al. | 14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27591243 |
Kandhi S et al. | EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26498250 |
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Alvarez DF et al. | Role of EETs in regulation of endothelial permeability in rat lung. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14578116 |
Pavlov TS et al. | Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21697242 |
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Morin C et al. | Epoxyeicosatrienoic acid relaxing effects involve Ca2+-activated K+ channel activation and CPI-17 dephosphorylation in human bronchi. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17237191 |
Morin C et al. | 17,18-epoxyeicosatetraenoic acid targets PPARγ and p38 mitogen-activated protein kinase to mediate its anti-inflammatory effects in the lung: role of soluble epoxide hydrolase. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20008283 |
Morin C et al. | CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18757304 |
Morin C et al. | EET displays anti-inflammatory effects in TNF-alpha stimulated human bronchi: putative role of CPI-17. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17872494 |
Alvarez DF et al. | Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16051904 |
Schebb NH et al. | Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. | 2011 | Anal Bioanal Chem | pmid:21479549 |
Hammonds TD et al. | Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. | 1989 | Anal. Biochem. | pmid:2610347 |
Nithipatikom K et al. | Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | 2001 | Anal. Biochem. | pmid:11319825 |
Nithipatikom K et al. | Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. | 1997 | Anal. Biochem. | pmid:9073364 |
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Dunn LK et al. | Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). | 2005 | Anat Rec A Discov Mol Cell Evol Biol | pmid:15952186 |
Lamb DC et al. | Streptomyces coelicolor A3(2) CYP102 protein, a novel fatty acid hydroxylase encoded as a heme domain without an N-terminal redox partner. | 2010 | Appl. Environ. Microbiol. | pmid:20097805 |
Capdevila J et al. | Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. | 1985 | Arch. Biochem. Biophys. | pmid:3933431 |
Oleksiak MF et al. | Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. | 2003 | Arch. Biochem. Biophys. | pmid:12623071 |
Capdevila JH et al. | NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. | 1988 | Arch. Biochem. Biophys. | pmid:3341770 |
Spiecker M and Liao JK | Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids. | 2005 | Arch. Biochem. Biophys. | pmid:15581597 |
Gupta NC et al. | Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22723436 |
Krötz F et al. | Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14715644 |
Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
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Peri KG et al. | A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9514882 |
Pritchard KA et al. | 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2310385 |
Lin WK et al. | Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2322287 |
Karara A et al. | Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1540175 |
Wang L et al. | 14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24931672 |
Xiao ZL et al. | Demonstration of endogenous inhibitors for the formation of 14,15-oxido-5,8,11-eicosatrienoic acid from phosphatidylinositol in bovine lung extract. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3421969 |
Capdevila JH et al. | A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619897 |
Seki K et al. | Epoxyeicosatrienoic acid stimulates ADP-ribosylation of a 52 kDa protein in rat liver cytosol. | 1992 | Biochem. J. | pmid:1731754 |
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Chen Y et al. | 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. | 2011 | Biochemistry | pmid:21469660 |