MeSH term | MeSH ID | Detail |
---|---|---|
Coronary Occlusion | D054059 | 4 associated lipids |
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
pmid: | ||||
Huang S et al. | Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. | 1999 | Kidney Int. | pmid:10231436 |
Lee HC et al. | Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. | 1999 | J. Physiol. (Lond.) | pmid:10432346 |
Node K et al. | Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. | 1999 | Science | pmid:10455056 |
Weintraub NL et al. | Epoxide hydrolases regulate epoxyeicosatrienoic acid incorporation into coronary endothelial phospholipids. | 1999 | Am. J. Physiol. | pmid:10564166 |
Silverstein DM et al. | Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10582656 |
Fang X et al. | Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells. | 1999 | Hypertension | pmid:10601125 |
Zhu D et al. | Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666118 |
Yu Z et al. | Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney. | 2000 | Mol. Pharmacol. | pmid:10779386 |
Chen JK et al. | Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. | 2000 | J. Biol. Chem. | pmid:10788500 |
Tréluyer JM et al. | Ontogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome. | 2000 | Pediatr. Res. | pmid:10813596 |
Wu SN et al. | Actions of epoxyeicosatrienoic acid on large-conductance Ca(2+)-activated K(+) channels in pituitary GH(3) cells. | 2000 | Biochem. Pharmacol. | pmid:10825470 |
Nithipatikom K et al. | Determination of EETs using microbore liquid chromatography with fluorescence detection. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924087 |
Wong PY et al. | Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060896 |
Yu Z et al. | Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. | 2000 | Circ. Res. | pmid:11090543 |
Pratt PF et al. | Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179054 |
Fang X et al. | Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. | 2001 | J. Biol. Chem. | pmid:11278979 |
Node K et al. | Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids. | 2001 | J. Biol. Chem. | pmid:11279071 |
Benoit C et al. | EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11290521 |
Nithipatikom K et al. | Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs. | 2001 | Anal. Biochem. | pmid:11319825 |
Zhang Y et al. | EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356595 |
Rastaldo R et al. | Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11356641 |
Imig JD et al. | Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid. | 2001 | J. Hypertens. | pmid:11393683 |
Medhora M et al. | Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids. | 2001 | Trends Cardiovasc. Med. | pmid:11413051 |
Krishna UM et al. | Stereospecific synthesis of trans-arachidonic acids. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11549436 |
Miller AW et al. | Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11557540 |
Fisslthaler B et al. | Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. | 2001 | Hypertension | pmid:11751730 |
Salvail D et al. | Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle. | 2002 | Am. J. Physiol., Cell Physiol. | pmid:11832342 |
Campbell WB et al. | 14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11959628 |
Gauthier KM et al. | 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. | 2002 | Circ. Res. | pmid:12016270 |
Snyder GD et al. | Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12384472 |
Falck JR et al. | Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388250 |
Medhora M et al. | Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388259 |
Fang X et al. | Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388281 |
Zhang C and Harder DR | Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic Acid. | 2002 | Stroke | pmid:12468797 |
Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
Oleksiak MF et al. | Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. | 2003 | Arch. Biochem. Biophys. | pmid:12623071 |
Fang X et al. | Differences in positional esterification of 14,15-epoxyeicosatrienoic acid in phosphatidylcholine of porcine coronary artery endothelial and smooth muscle cells. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:12749592 |
Wang D et al. | Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles. | 2003 | Kidney Int. | pmid:12753306 |
Miyazono M et al. | Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis. | 2003 | J. Am. Soc. Nephrol. | pmid:12819236 |
Ladd PA et al. | Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. | 2003 | J. Biol. Chem. | pmid:12840027 |
Gauthier KM et al. | 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. | 2003 | Hypertension | pmid:12953017 |
Malcolm KC and Fitzpatrick FA | Epoxyeicosatrienoic acids inhibit Ca2+ entry into platelets stimulated by thapsigargin and thrombin. | 1992 | J. Biol. Chem. | pmid:1400301 |
Alvarez DF et al. | Role of EETs in regulation of endothelial permeability in rat lung. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14578116 |
Krötz F et al. | Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14715644 |
Gauthier KM et al. | 14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries. | 2004 | Pharmacol. Res. | pmid:15026029 |
Fang X et al. | Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15284062 |
Ye D et al. | Activation of rat mesenteric arterial KATP channels by 11,12-epoxyeicosatrienoic acid. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15331373 |
Karara A et al. | Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1540175 |
Gauthier KM et al. | Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15528233 |