| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Prostaglandins Other Lipid Mediat. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- J. Lipid Res. (1)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Hypertension (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:24880050 | ||||
| pmid:24607498 | ||||
| pmid:24486707 | ||||
| Amara IE et al. | Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. | 2014 | Toxicol. Lett. | pmid:24472606 |
| Diani-Moore S et al. | Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. | 2014 | Drug Metab. Dispos. | pmid:24311719 |
| Althurwi HN et al. | Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. | 2014 | J. Cardiovasc. Pharmacol. | pmid:24157956 |
| Samokhvalov V et al. | Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. | 2013 | Cell Death Dis | pmid:24157879 |
| Yang T et al. | The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. | 2013 | Lipids Health Dis | pmid:24148690 |
| Wang X et al. | CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. | 2014 | Mol. Pharmacol. | pmid:24145329 |
| Eid S et al. | 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. | 2013 | PLoS ONE | pmid:23936373 |
| Karara A et al. | Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. | 1990 | FEBS Lett. | pmid:2384159 |
| Capdevila JH et al. | Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. | 1990 | J. Biol. Chem. | pmid:2358445 |
| Tse MM et al. | Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. | 2013 May-Jun | Vascul. Pharmacol. | pmid:23466634 |
| Podolin PL et al. | In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23434473 |
| Gross GJ et al. | Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. | 2013 | J. Mol. Cell. Cardiol. | pmid:23419451 |
| Tabet Y et al. | Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23418089 |
| Nelson JW et al. | Soluble epoxide hydrolase dimerization is required for hydrolase activity. | 2013 | J. Biol. Chem. | pmid:23362272 |
| Pidkovka N et al. | Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. | 2013 | J. Biol. Chem. | pmid:23283969 |
| Chen L et al. | Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23247129 |
| Lin WK et al. | Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2322287 |