| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperemia | D006940 | 25 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertrophy | D006984 | 16 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Pre-Eclampsia | D011225 | 16 associated lipids |
| Coronary Occlusion | D054059 | 4 associated lipids |
14,15-eet
14,15-eet is a lipid of Fatty Acyls (FA) class. 14,15-eet is associated with abnormalities such as Heart failure, Chronic Obstructive Airway Disease, Pneumonia and Fatty Liver. The involved functions are known as chromophore, Stereochemistry, Cell Respiration, cell transformation and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. 14,15-eet often locates in Lambda, Cardiovascular system, Blood, Body tissue and Protoplasm. The associated genes with 14,15-eet are CCL2 gene, Cytokine Gene, CYP2C18 gene, CYP2C19 gene and TEK gene. The related lipids are Palmitates.
Cross Reference
Introduction
To understand associated biological information of 14,15-eet, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 14,15-eet?
14,15-eet is suspected in Heart failure, Chronic Obstructive Airway Disease, Pneumonia, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Prostaglandins Other Lipid Mediat. (1)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 14,15-eet
PubChem Associated disorders and diseases
What pathways are associated with 14,15-eet
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 14,15-eet?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Hypertension (1)
- Insect Biochem. Mol. Biol. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 14,15-eet?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 14,15-eet?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 14,15-eet?
Related references are published most in these journals:
- Hypertension (1)
- Prostaglandins Other Lipid Mediat. (1)
- Am. J. Physiol. Endocrinol. Metab. (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 14,15-eet?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 14,15-eet
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kopf PG et al. | Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs. | 2011 | Hypertension | pmid:21199991 |
| Ellis EF et al. | Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid. | 1990 | Am. J. Physiol. | pmid:2121049 |
| Sridar C et al. | Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6. | 2011 | Drug Metab. Dispos. | pmid:21289075 |
| Mitra R et al. | CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). | 2011 | J. Biol. Chem. | pmid:21402692 |
| Chen Y et al. | 20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. | 2011 | Biochemistry | pmid:21469660 |
| Schebb NH et al. | Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. | 2011 | Anal Bioanal Chem | pmid:21479549 |
| Henrich WL et al. | Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices. | 1990 | Am. J. Physiol. | pmid:2154933 |
| Harris RC et al. | Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. | 1990 | J. Cell. Physiol. | pmid:2167900 |
| Ward NC et al. | Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls. | 2011 | Clin. Sci. | pmid:21689071 |
| Pavlov TS et al. | Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC). | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21697242 |
| Gauthier KM et al. | Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles. | 2011 | Am. J. Physiol. Renal Physiol. | pmid:21753077 |
| Farr H and David T | Models of neurovascular coupling via potassium and EET signalling. | 2011 | J. Theor. Biol. | pmid:21781976 |
| Zhu P et al. | Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21798825 |
| Senouvo FY et al. | Improved bioavailability of epoxyeicosatrienoic acids reduces TP-receptor agonist-induced tension in human bronchi. | 2011 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21821730 |
| Sarkar P et al. | Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain. | 2011 | Neuroscience | pmid:21843605 |
| Catella F et al. | Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2198572 |
| Shao J et al. | P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. | 2011 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:22038346 |
| Zhang D et al. | Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. | 2012 | Circ. Res. | pmid:22354938 |
| Gross GJ et al. | Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:22407888 |
| Theken KN et al. | Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease. | 2012 | Atherosclerosis | pmid:22503544 |
| Gupta NC et al. | Soluble epoxide hydrolase: sex differences and role in endothelial cell survival. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22723436 |
| Chadderdon SM et al. | Activity restriction, impaired capillary function, and the development of insulin resistance in lean primates. | 2012 | Am. J. Physiol. Endocrinol. Metab. | pmid:22739105 |
| Decker M et al. | EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. | 2012 | J. Lipid Res. | pmid:22798687 |
| Terashvili M et al. | The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture. | 2012 | Neuroscience | pmid:22863680 |
| Chaudhary KR et al. | Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22922020 |
| Oni-Orisan A et al. | Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23000418 |
| Li R et al. | Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:23041291 |
| Pritchard KA et al. | 14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2310385 |
| Wang SB et al. | Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. | 2012 | J Asian Nat Prod Res | pmid:23106500 |
| Sander AL et al. | Soluble epoxide hydrolase disruption as therapeutic target for wound healing. | 2013 | J. Surg. Res. | pmid:23122666 |
| Herse F et al. | Cytochrome P450 subfamily 2J polypeptide 2 expression and circulating epoxyeicosatrienoic metabolites in preeclampsia. | 2012 | Circulation | pmid:23155181 |
| Cracowski JL et al. | Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans. | 2013 | J. Appl. Physiol. | pmid:23172029 |
| Lin WK et al. | Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2322287 |
| Chen L et al. | Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23247129 |
| Pidkovka N et al. | Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. | 2013 | J. Biol. Chem. | pmid:23283969 |
| Nelson JW et al. | Soluble epoxide hydrolase dimerization is required for hydrolase activity. | 2013 | J. Biol. Chem. | pmid:23362272 |
| Tabet Y et al. | Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23418089 |
| Gross GJ et al. | Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. | 2013 | J. Mol. Cell. Cardiol. | pmid:23419451 |
| Podolin PL et al. | In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:23434473 |
| Tse MM et al. | Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. | 2013 May-Jun | Vascul. Pharmacol. | pmid:23466634 |
| Capdevila JH et al. | Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. | 1990 | J. Biol. Chem. | pmid:2358445 |
| Karara A et al. | Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. | 1990 | FEBS Lett. | pmid:2384159 |
| Eid S et al. | 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. | 2013 | PLoS ONE | pmid:23936373 |
| Wang X et al. | CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. | 2014 | Mol. Pharmacol. | pmid:24145329 |
| Yang T et al. | The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. | 2013 | Lipids Health Dis | pmid:24148690 |
| Samokhvalov V et al. | Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. | 2013 | Cell Death Dis | pmid:24157879 |
| Althurwi HN et al. | Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. | 2014 | J. Cardiovasc. Pharmacol. | pmid:24157956 |
| Diani-Moore S et al. | Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. | 2014 | Drug Metab. Dispos. | pmid:24311719 |
| Amara IE et al. | Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. | 2014 | Toxicol. Lett. | pmid:24472606 |
| pmid:24486707 |