Chen JK et al. |
Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. |
1999 |
J. Biol. Chem. |
pmid:9988714
|
Hutcheson IR et al. |
Nitric oxide-independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication. Role of Gap junctions and phospholipase A2. |
1999 Jan 8-22 |
Circ. Res. |
pmid:9915774
|
Rzigalinski BA et al. |
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid. |
1999 |
J. Biol. Chem. |
pmid:9867827
|
Medhora M and Harder D |
Functional role of epoxyeicosatrienoic acids and their production in astrocytes: approaches for gene transfer and therapy (review). |
1998 |
Int. J. Mol. Med. |
pmid:9850733
|
Fang X et al. |
14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells. |
1998 |
Am. J. Physiol. |
pmid:9843811
|
Gebremedhin D et al. |
Bioassay of an endothelium-derived hyperpolarizing factor from bovine coronary arteries: role of a cytochrome P450 metabolite. |
1998 Jul-Aug |
J. Vasc. Res. |
pmid:9701712
|
Peri KG et al. |
A role for protein kinase C alpha in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. |
1998 |
Biochem. Biophys. Res. Commun. |
pmid:9514882
|
Fang X et al. |
Cytochrome P450 metabolites of arachidonic acid: rapid incorporation and hydration of 14,15-epoxyeicosatrienoic acid in arterial smooth muscle cells. |
1997 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:9430380
|
Baron A et al. |
Epoxyeicosatrienoic acids activate a high-conductance, Ca(2+)-dependent K + channel on pig coronary artery endothelial cells. |
1997 |
J. Physiol. (Lond.) |
pmid:9401962
|
Peri KG et al. |
Stimulation of prostaglandin G/H synthase-2 expression by arachidonic acid monoxygenase product, 14,15-epoxyeicosatrienoic acid. |
1997 |
FEBS Lett. |
pmid:9373167
|
Leffler CW and Fedinec AL |
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids. |
1997 |
Am. J. Physiol. |
pmid:9249508
|
Wong PY et al. |
Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells. |
1997 |
J Lipid Mediat Cell Signal |
pmid:9246605
|
Weintraub NL et al. |
Potentiation of endothelium-dependent relaxation by epoxyeicosatrienoic acids. |
1997 |
Circ. Res. |
pmid:9242187
|
Nithipatikom K et al. |
Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay. |
1997 |
Anal. Biochem. |
pmid:9073364
|
Zou AP et al. |
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity. |
1996 |
Am. J. Physiol. |
pmid:8928844
|
Zeldin DC et al. |
CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. |
1996 |
Mol. Pharmacol. |
pmid:8913342
|
Capdevila JH et al. |
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. |
1996 |
J. Biol. Chem. |
pmid:8798438
|
Alkayed NJ et al. |
Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. |
1996 |
Stroke |
pmid:8623121
|
Moffat MP et al. |
Effects of epoxyeicosatrienoic acids on isolated hearts and ventricular myocytes. |
1993 |
Am. J. Physiol. |
pmid:8476093
|
Rosolowsky M and Campbell WB |
Role of PGI2 and epoxyeicosatrienoic acids in relaxation of bovine coronary arteries to arachidonic acid. |
1993 |
Am. J. Physiol. |
pmid:8447448
|
Imig JD et al. |
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. |
1994 |
Am. J. Physiol. |
pmid:8203587
|
Ma YH et al. |
Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. |
1994 |
Am. J. Physiol. |
pmid:8067471
|
Staudinger R et al. |
Effects of epoxyeicosatrienoic acids on 86Rb uptake in renal epithelial cells. |
1994 |
J. Cell. Physiol. |
pmid:8021300
|
Daikh BE et al. |
Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C9. |
1994 |
J. Pharmacol. Exp. Ther. |
pmid:7996455
|
Shivachar AC et al. |
Effect of protein kinase C modulators on 14,15-epoxyeicosatrienoic acid incorporation into astroglial phospholipids. |
1995 |
J. Neurochem. |
pmid:7790878
|
VanRollins M et al. |
Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo. |
1995 |
Biochim. Biophys. Acta |
pmid:7786887
|
Zhu Y et al. |
Identification of arachidonate P-450 metabolites in human platelet phospholipids. |
1995 |
Hypertension |
pmid:7721444
|
Fang X et al. |
Epoxyeicosatrienoic acid metabolism in arterial smooth muscle cells. |
1995 |
J. Lipid Res. |
pmid:7666001
|
Zosmer A et al. |
Formation and metabolism of 14,15-epoxyeicosatrienoic acid by human reproductive tissues. |
1995 |
Biochim. Biophys. Acta |
pmid:7548192
|
Capdevila J et al. |
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450. |
1985 |
Arch. Biochem. Biophys. |
pmid:3933431
|
Carroll MA et al. |
Vasoactivity of arachidonic acid epoxides. |
1987 |
Eur. J. Pharmacol. |
pmid:3622613
|
Capdevila JH et al. |
A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs). |
1987 |
Biochem. Biophys. Res. Commun. |
pmid:3619897
|
Xiao ZL et al. |
Demonstration of endogenous inhibitors for the formation of 14,15-oxido-5,8,11-eicosatrienoic acid from phosphatidylinositol in bovine lung extract. |
1988 |
Biochem. Biophys. Res. Commun. |
pmid:3421969
|
Capdevila JH et al. |
NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. |
1988 |
Arch. Biochem. Biophys. |
pmid:3341770
|
Ballou LR et al. |
Formation of cis-14,15-oxido-5,8,11-icosatrienoic acid from phosphatidylinositol in human platelets. |
1987 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:3118357
|
Proctor KG et al. |
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase. |
1987 |
Circ. Res. |
pmid:3105909
|
Fitzpatrick FA et al. |
Inhibition of cyclooxygenase activity and platelet aggregation by epoxyeicosatrienoic acids. Influence of stereochemistry. |
1986 |
J. Biol. Chem. |
pmid:3095326
|
McGee J and Fitzpatrick F |
Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. |
1985 |
J. Biol. Chem. |
pmid:2995393
|
|
|
|
|
pmid:28958841
|
|
|
|
|
pmid:28526610
|
|
|
|
|
pmid:28374982
|
Schlondorff D et al. |
Epoxygenase metabolites of arachidonic acid inhibit vasopressin response in toad bladder. |
1987 |
Am. J. Physiol. |
pmid:2820243
|
|
|
|
|
pmid:28052015
|
|
|
|
|
pmid:27980032
|
Sporková A et al. |
Vasodilatory responses of renal interlobular arteries to epoxyeicosatrienoic acids analog are not enhanced in Ren-2 transgenic hypertensive rats: evidence against a role of direct vascular effects of epoxyeicosatrienoic acids in progression of experimental heart failure. |
2017 |
Physiol Res |
pmid:27782740
|
|
|
|
|
pmid:27753791
|
|
|
|
|
pmid:27633970
|
Li Y et al. |
14,15-Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy. |
2016 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:27591243
|
El-Sikhry HE et al. |
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria. |
2016 |
PLoS ONE |
pmid:27494529
|
|
|
|
|
pmid:27270316
|
|
|
|
|
pmid:27166927
|
Sporková A et al. |
Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids. |
2016 |
Am. J. Med. Sci. |
pmid:27140711
|
|
|
|
|
pmid:26975734
|
|
|
|
|
pmid:26545915
|
|
|
|
|
pmid:26526810
|
Kandhi S et al. |
EET-dependent potentiation of pulmonary arterial pressure: sex-different regulation of soluble epoxide hydrolase. |
2015 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:26498250
|
Kandhi S et al. |
EETs Elicit Direct Increases in Pulmonary Arterial Pressure in Mice. |
2016 |
Am. J. Hypertens. |
pmid:26304959
|
|
|
|
|
pmid:26304700
|
|
|
|
|
pmid:26253834
|
Li P et al. |
Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. |
2015 |
Nature |
pmid:26201599
|
Hammonds TD et al. |
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. |
1989 |
Anal. Biochem. |
pmid:2610347
|
Jiang JX et al. |
EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. |
2015 |
PLoS ONE |
pmid:26035589
|
Yu G et al. |
14,15-epoxyeicosatrienoic Acid suppresses cigarette smoke extract-induced apoptosis in lung epithelial cells by inhibiting endoplasmic reticulum stress. |
2015 |
Cell. Physiol. Biochem. |
pmid:25968975
|
Karara A et al. |
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. |
1989 |
J. Biol. Chem. |
pmid:2584196
|
Xu J et al. |
Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. |
2015 |
Insect Biochem. Mol. Biol. |
pmid:25686802
|
Yang L et al. |
CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. |
2015 Jan-Mar |
Prostaglandins Other Lipid Mediat. |
pmid:25686540
|
Snyder GD et al. |
Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. |
1989 |
Am. J. Physiol. |
pmid:2563927
|
Imig JD |
Epoxyeicosatrienoic acids, hypertension, and kidney injury. |
2015 |
Hypertension |
pmid:25583156
|
|
|
|
|
pmid:25467970
|
Wei X et al. |
Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. |
2014 |
BMC Cancer |
pmid:25406731
|
Chen G et al. |
CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice. |
2015 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:25389366
|
|
|
|
|
pmid:25370574
|
|
|
|
|
pmid:25366463
|
Teder T et al. |
Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. |
2014 |
J. Lipid Res. |
pmid:25293588
|
Siler DA et al. |
Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage. |
2015 |
Neurocrit Care |
pmid:25231529
|
Su KH et al. |
Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. |
2014 |
Int. J. Biol. Sci. |
pmid:25210497
|
Patel L et al. |
Production of epoxygenase metabolite by human reproductive tissues. |
1989 |
Prostaglandins |
pmid:2517348
|
|
|
|
|
pmid:25128026
|
Falck JR et al. |
14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications. |
2014 |
J. Med. Chem. |
pmid:25119815
|
Wang L et al. |
14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24931672
|
|
|
|
|
pmid:24880050
|
|
|
|
|
pmid:24607498
|
|
|
|
|
pmid:24486707
|
Amara IE et al. |
Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. |
2014 |
Toxicol. Lett. |
pmid:24472606
|
Diani-Moore S et al. |
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. |
2014 |
Drug Metab. Dispos. |
pmid:24311719
|
Althurwi HN et al. |
Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. |
2014 |
J. Cardiovasc. Pharmacol. |
pmid:24157956
|
Samokhvalov V et al. |
Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response. |
2013 |
Cell Death Dis |
pmid:24157879
|
Yang T et al. |
The role of 14,15-dihydroxyeicosatrienoic acid levels in inflammation and its relationship to lipoproteins. |
2013 |
Lipids Health Dis |
pmid:24148690
|
Wang X et al. |
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure. |
2014 |
Mol. Pharmacol. |
pmid:24145329
|
Eid S et al. |
20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. |
2013 |
PLoS ONE |
pmid:23936373
|
Karara A et al. |
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. |
1990 |
FEBS Lett. |
pmid:2384159
|
Capdevila JH et al. |
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. |
1990 |
J. Biol. Chem. |
pmid:2358445
|
Tse MM et al. |
Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. |
2013 May-Jun |
Vascul. Pharmacol. |
pmid:23466634
|
Podolin PL et al. |
In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:23434473
|
Gross GJ et al. |
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. |
2013 |
J. Mol. Cell. Cardiol. |
pmid:23419451
|
Tabet Y et al. |
Relationship between bradykinin-induced relaxation and endogenous epoxyeicosanoid synthesis in human bronchi. |
2013 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:23418089
|
Nelson JW et al. |
Soluble epoxide hydrolase dimerization is required for hydrolase activity. |
2013 |
J. Biol. Chem. |
pmid:23362272
|
Pidkovka N et al. |
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation. |
2013 |
J. Biol. Chem. |
pmid:23283969
|
Chen L et al. |
Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. |
2013 Jul-Aug |
Prostaglandins Other Lipid Mediat. |
pmid:23247129
|
Lin WK et al. |
Effect of 14,15-epoxyeicosatrienoic acid infusion on blood pressure in normal and hypertensive rats. |
1990 |
Biochem. Biophys. Res. Commun. |
pmid:2322287
|